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51.
52.
Klinična pot presejanja oseb z visoko ogroženostjo za razvoj raka trebušne slinavke
Barbara Perić, Ana Blatnik, Aleš Tomažič, Aleksandar Gavrić, Borut Štabuc, Srdjan Novaković, Mateja Krajc, 2021, dictionary, encyclopaedia, lexicon, manual, atlas, map

Keywords: rak trebušne slinavke, bolniki, klinične poti
Published in DiRROS: 14.02.2022; Views: 894; Downloads: 386
.pdf Full text (868,10 KB)
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Analysis of wood biomass potential in Slovenia : final report
Robert Robek, Mirko Medved, Lojze Žgajnar, Nike Krajnc, Borut Bitenc, 1998, final research report

Published in DiRROS: 03.11.2021; Views: 780; Downloads: 218
.pdf Full text (11,77 MB)

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Priporočila Onkološkega inštituta za zdravljenje bolnikov z adenokarcinomom želodca
2021, other monographs and other completed works

Abstract: V Sloveniji vsako leto zboli zaradi raka želodca okrog 450 bolnikov, od tega ima tri četrtine bolnikov ob postavitvi diagnoze razširjeno ali razsejano bolezen. Zato je pomembno, da imamo razvito sodobno multidisciplinarno zdravljenje. Onkološki inštitut je na poti pridobitve evropske onkološke akreditacije, ki jo podeljuje priznana Evropska organizacija onkoloških inštitutov (OECI), katere član je tudi Onkološki inštitut Ljubljana. Namen tega projekta je razvoj kliničnih poti, ki bodo omogočile celostno obravnavo bolnikov z rakom. Slovenskih priporočil za zdravljenje adenokarcinoma želodca trenutno nimamo, zato smo bili primorani sprejeti te, ki jim bomo sledili na Onkološkem inštitutu. V teh priporočilih, zaradi drugačne narave bolezni, ni zajeto zdravljenje raka ezofagogastričnega stika.
Keywords: rak želodca, adenokarcinom, onkološko zdravljenje, priporočila
Published in DiRROS: 14.09.2021; Views: 1480; Downloads: 394
.pdf Full text (983,68 KB)

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Epitope mapping of major ragweed allergen Amb a 1
Abida Zahirović, Borut Štrukelj, Peter Korošec, Mojca Lunder, 2019, original scientific article

Abstract: Ragweed is a prominent cause of seasonal allergies. Thus far, information on IgE-binding sites of major allergen in ragweed pollen, Amb a 1, is very limited. A powerful experimental method to gain insights on the allergen epitopes is the selection of peptides from biological libraries that bind to anti-allergen antibodies. In this work, we aimed to map IgE epitopes of Amb a 1 using epitope-mimicking short peptides % mimotopes that were affinity-selected from phage-displayed random peptide libraries. The peptides weakly aligned with the Amb a 1 primary sequence, thus suggesting that the epitopes are conformational. When the peptides were mapped onto the surface of Amb a 1 homology model, the EpiSearch analysis predicted the location of four potential epitopic sites on surface patches centred at residues K104, S110, H214, and W312. The peptides matching to the predicted epitopes bound selectively to the IgE from pool of ragweed-allergic patients% sera and therefore represent mimetics of Amb a 1 IgE epitopes. The knowledge of IgE epitopes is a prerequisite for the rational design of molecular-based approaches to diagnosis and immunotherapy of allergic diseases.
Keywords: allergens, ragweed allergy, Amb a 1, epitope mapping, phage display, mimotopes
Published in DiRROS: 09.11.2020; Views: 1346; Downloads: 915
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