1. Early cardiotoxicity after adjuvant concomitant treatment with radiotherapy and trastuzumab in patients with breast cancerTanja Marinko, Simona Borštnar, Rok Blagus, Jure Dolenc, Cvetka Bilban-Jakopin, 2018, original scientific article Keywords: radiotherapy, adjuvant radiotherapy, cardiotoxicity, breast cancer
Published in DiRROS: 10.06.2024; Views: 12; Downloads: 3
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3. Implant-prosthetic rehabilitation after radiation treatment in head and neck cancer patients : a case-series report of outcomeJasna Cotič, Jure Jamšek, Milan Kuhar, Nataša Ihan Hren, Andrej Kansky, Mutlu Özcan, Peter Jevnikar, 2017, original scientific article Abstract: Background. Slovenia has a high burden of head and neck cancer. Patients are mostly treated with surgery followed by radiation therapy. Advanced surgical and prosthodontic techniques have expanded the rehabilitation options. The aim of the study was to review the outcome of implant-prosthetic treatment after radiation therapy. Patients and methods. Twenty irradiated head and neck cancer patients who received a removable implantsupported denture at the University Medical Centre Ljubljana were included in the study. Kaplan-Meier survival analysis, Cox proportional hazard models and logistic regression were used to assess the implant survival and success rate. Results. Twenty patients had 100 implants inserted. The estimated implant survival rate was 96% after 1 year and 87% after 5 years. Failures were mostly observed before loading (91.2%). Implants inserted in the transplanted bone were significantly more likely to fail. Out of 89 implants supporting the dentures, 79 implants (88.7%) were successful, meaning that they were functionally loaded and exhibited no pain, radiolucency or progressive bone loss. Prosthetic treatment was significantly less successful in older patients. The attachment system and the number of implants did not have a statistically significant influence on the success rate. Conclusions. Implant-supported dentures have been shown to be a reliable treatment modality after head and neck cancer surgery and radiation therapy. Possible early failures should be communicated with the patients.
Keywords: head and neck cancer, radiation therapy, dental implants
Published in DiRROS: 03.06.2024; Views: 63; Downloads: 25
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5. Electrochemotherapy by pulsed electromagnetic field treatment (PEMF) in mouse melanoma B16F10 in vivoSimona Kranjc Brezar, Matej Kranjc, Janez Ščančar, Jure Jelenc, Gregor Serša, Damijan Miklavčič, 2016, original scientific article Keywords: pulsed electromagnetic field, bipolar pulses, contactless electroporation, CDDP, electrochemotherapy, mouse melanoma
Published in DiRROS: 09.05.2024; Views: 124; Downloads: 101
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6. Jugoslavija i ambivalentnost ekonomske saradnje Jug-Jug u sedamdesetim i osamdesetim godinamaJure Ramšak, 2024, original scientific article Abstract: Na vrhuncu napora zemalja u razvoju da uspostave Novi međunarodni ekonomski poredak, Jugoslavija je, kao jedna od vodećih članica Pokreta nesvrstanih i Grupe 77 zemalja u razvoju (G-77), nastojala da dokaže da je moguće uspostaviti novi obrazac odnosa između industrijski razvijenih zemalja, kojima je delimično i sama pripadala i saveznika iz ove koalicije, čije su ekonomske baze još uvek bile u fazi izgradnje. U skladu sa određenim dominantnim grupama unutar UN-a, jugoslovenska teorija razvoja spajala je marksistička sa neoklasičnim ekonomskim shvatanjima u ambiciozan program globalne reforme koja je odstupala od stavova kapitalističkih i socijalističkih velesila. Ipak, u isto vreme, ova vizija globalizacije morala je da se nosi sa ideološkim, geopolitičkim i ekonomskim uticajem novonastale neoliberalne revolucije, koja je početkom osamdesetih počela bitno sužavati prostor za manevrisanje. Pored programskih načela sadržanih u zvaničnim dokumentima, ovaj rad prati i konkretne oblike jugoslovenske bilateralne ekonomske saradnje sa pojedinim afričkim zemljama.
Published in DiRROS: 06.05.2024; Views: 176; Downloads: 89
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7. Revealing subtle active tectonic deformation: integrating lidar, photogrammetry, field mapping, and geophysical surveys to assess the Late Quaternary activity of the Sava Fault (Southern Alps, Slovenia)Petra Jamšek Rupnik, Jure Atanackov, Barbara Horn, Branko Mušič, Marjana Zajc, Christoph Grützner, Kamil Ustaszewski, Sumiko Tsukamoto, Matevž Novak, Blaž Milanič, Anže Markelj, Kristina Ivančič, Ana Novak, Jernej Jež, Manja Žebre, Miloš Bavec, Marko Vrabec, 2024, original scientific article Abstract: We applied an interdisciplinary approach to analyze the late Quaternary activity of the Sava Fault in the Slovenian Southern Alps. The Sava Fault is an active strike-slip fault, and part of the Periadriatic Fault System that accommodated the convergence of Adria and Europe. It is one of the longest faults in the Southern Alps. Using high-resolution digital elevation models from lidar and photogrammetric surveys, we were able to overcome the challenges of assessing fault activity in a region with intense surface processes, dense vegetation, and relatively low fault slip rates. By integrating remote sensing analysis, geomorphological mapping, structural geological investigations, and near-surface geophysics (electrical resistivity tomography and ground penetrating radar), we were able to find subtle geomorphological indicators, detect near-surface deformation, and show distributed surface deformation and a complex fault pattern. Using optically stimulated luminescence dating, we tentatively estimated a slip rate of 1.8 ± 0.4 mm/a for the last 27 ka, which exceeds previous estimates and suggests temporal variability in fault behavior. Our study highlights the importance of modern high-resolution remote sensing techniques and interdisciplinary approaches in detecting tectonic deformation in relatively low-strain rate environments with intense surface processes. We show that slip rates can vary significantly depending on the studied time window. This is a critical piece of information since slip rates are a key input parameter for seismic hazard studies.
Keywords: active fault, lidar, photogrammetry, tectonic geomorphology, structural geology, geophysics, electrical resistivity tomography, ground penetrating radar, slip rate, Sava Fault
Published in DiRROS: 30.04.2024; Views: 150; Downloads: 102
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8. Towards deploying highly quantized neural networks on FPGA using chiselJure Vreča, Anton Biasizzo, 2023, published scientific conference contribution Abstract: We present chisel4ml, a Chisel-based tool that generates hardware for highly quantized neural networks described in QKeras. Such networks typically use parameters with bitwidths less than 8 bits and may have pruned connections. Chisel4ml can generate the highly quantized neural network as a single combinational circuit with pipeline registers in between the different layers. It supports heterogeneous quantization where each layer can have a different precision. The full parallelization enables very low-latency and high throughput inference, that are required for certain tasks. We illustrate this on the triggering system for the CERN Large Hadron Collider, which filters out events of interest and sends them on for further processing. We compare our tool against hls4ml, a high-level synthesis based approach for deploying similar neural networks. Chisel4ml is still under development. However, it already achieves comparable results to hls4ml for some neural network architectures. Chisel4ml is available on https://github.com/cs-jsi/chisel4ml.
Keywords: neural networks, QKeras, Chisel4ml
Published in DiRROS: 23.04.2024; Views: 130; Downloads: 73
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10. Cardiotoxicity of concomitant radiotherapy and trastuzumab for early breast cancerTanja Marinko, Jure Dolenc, Cvetka Bilban-Jakopin, 2014, original scientific article Abstract: Background. Trastuzumab therapy given in combination with one of several chemotherapy regimens is currently considered the standard of care for the treatment of early-stage, human epidermal growth factor receptor-2 (HER2) -positive breast cancer. The treatment with trastuzumab is due to a significant impact on the survival part of the standard adjuvant treatment of patients with HER2-positive breast cancer. Patients treated with postoperative breast or chest wall irradiation receive trastuzumab concomitant with radiotherapy. In a small proportion of patients trastuzumab causes cardiotoxicity. Preclinical findings indicate a radiosensibilizing effect of trastuzumab in breast cancer cells, but it is not yet clear whether it radiosensibilizes cells of healthy tissues too.Conclusions. Special attention is required when left breast or left thoracic wall is irradiated in patient receiving trastuzumab, because long-term effects of the concurrent treatment with trastuzumab and radiotherapy are not yet known. In an era where more patients are surviving a diagnosis of breast cancer, better understanding and earlier detection of therapy-induced cardiac toxicity will be of paramount importance.
Keywords: radiotherapy, cardiotoxicity, trastuzumab, early breast cancer
Published in DiRROS: 11.04.2024; Views: 165; Downloads: 76
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