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1.
Dynamic contrast-enhanced MRI of malignant pleural mesothelioma : a comparative study of pharmacokinetic models and correlation with mRECIST criteria
Martina Vivoda Tomšič, Sotirios Bisdas, Viljem Kovač, Igor Serša, Katarina Šurlan Popović, 2019, izvirni znanstveni članek

Povzetek: BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare and aggressive thoracic malignancy that is difficult to cure. Dynamic contrast-enhanced (DCE) MRI is a functional imaging technique used to analyze tumor microvascular properties and to monitor therapy response. Purpose of this study was to compare two tracer kinetic models, the extended Tofts (ET) and the adiabatic approximation tissue homogeneity model (AATH) for analysis of DCE-MRI and examine the value of the DCE parameters to predict response to chemotherapy in patients with MPM. METHOD: This prospective, longitudinal, single tertiary radiology center study was conducted between October 2013 and July 2015. Patient underwent DCE-MRI studies at three time points: prior to therapy, during and after cisplatin-based chemotherapy. The images were analyzed using ET and AATH models. In short-term follow-up, the patients were classified as having disease control or progressive disease according to modified response evaluation criteria in solid tumors (mRECIST) criteria. Receiver operating characteristic curve analysis was used to examine specificity and sensitivity of DCE parameters for predicting response to therapy. Comparison tests were used to analyze whether derived parameters are interchangeable between the two models. RESULTS: Nineteen patients form the study population. The results indicate that the derived parameters are not interchangeable between the models. Significant correlation with response to therapy was found for AATH-calculated median pre-treatment efflux rate (kep) showing sensitivity of 83% and specificity of 100% (AUC 0.9). ET-calculated maximal pre-treatment kep showed 100% sensitivity and specificity for predicting treatment response during the early phase of the therapy and reached a favorable trend to significant prognostic value post-therapy. CONCLUSION: Both models show potential in predicting response to therapy in MPM. High pre-treatment kep values suggest MPM disease control post-chemotherapy.
Ključne besede: biomarker, magnetic resonance imaging, mesothelioma, perfusion, response evaluation criteria in solid tumors, prognosis
Objavljeno v DiRROS: 23.09.2020; Ogledov: 1270; Prenosov: 932
.pdf Celotno besedilo (3,44 MB)
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2.
Launching work orders into production of wood enterprise with the multi-criteria decision-making method
Leon Oblak, Boštjan Novak, Igor Lipušček, Jože Kropivšek, 2007, pregledni znanstveni članek

Povzetek: Quality information is crucial for planning and running of production in wood industry companies. Information of crucial importance is the following: quality in the production process according to work orders and types of product, the information on the missing materials i.e. constituent parts according to projects i.e. work orders and the information on launching work orders into production. The method of multi-criteria decision-making was used for determining the order of launching group products into production. We studied three main criteria: market factors, organisation-production factors and economic factors. For computer support, we chose the computer programme DEXi, which represents the framework of the expert system for multi-criteria decision-making.
Ključne besede: wood enterprise, work orders, organization, multi-criteria decision-making method
Objavljeno v DiRROS: 12.07.2017; Ogledov: 4274; Prenosov: 1898
.pdf Celotno besedilo (648,58 KB)

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