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Abstract: Background/Objectives: Periodontitis is an inflammatory disease induced by bacteria in dental plaque that can activate the host’s immune-inflammatory response and invade the bloodstream. We hypothesized that a higher periodontal inflamed surface area (PISA) is associated with higher levels of inflammatory biomarkers, lower levels of antioxidants, and mitochondrial DNA copy number (mtDNAcn). Methods: Using periodontal parameters, we calculated the PISA score, measured the levels of inflammatory biomarkers and antioxidants in the serum, and took buccal swabs for mtDNA and nuclear DNA (nDNA) extraction. Results: Higher PISA was associated with higher CRP levels, higher leukocyte, neutrophil, and erythrocyte counts, and lower magnesium-to-calcium ratio, but not with mtDNAcn. A higher number of deep pockets was associated with higher leukocytes and neutrophil counts and higher uric acid levels. Conclusions: The PISA score might be an appropriate parameter to assess the inflammatory burden of periodontitis, but not to assess mitochondrial dysfunction after mtDNA isolation from buccal swabs.
Keywords: PISA, mitochondrial DNA copy number, mtDNA buccal swab, oxidative biomarkers
Published in DiRROS: 15.04.2026; Views: 43; Downloads: 33
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Keywords: vzgoja in izobraževanje, kreativnost, domišljija, pripovedovanje, oblikovanje, reševanje problemov, PISA, education, kreative minds, imagination, storytelling, design, problem solving
Published in DiRROS: 29.09.2025; Views: 668; Downloads: 305
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Abstract: Glede na prepoznan pomen globalnih kompetenc za uspešno (so)delovanje posameznikov v sodobnem šolskem, lokalnem in globalnem okolju (Svet Evrope, 2016; UNESCO, 2014), ki ga prepoznavajo tudi strateške usmeritve v Sloveniji (npr. Bela knjiga, 2011; Strategija razvoja Slovenije, 2017), smo analizi globalnih kompetenc slovenskih učencev in učenk, kot o njih poročajo v raziskavi PISA (2018), v znanstveni monografiji namenili posebno pozornost. Znanstvena monografija je nastala v okviru razvojno-strokovne naloge »Sekundarna študija PISA 2018: Globalne kompetence kot temelj uspešnega (so)delovanja v sodobnem šolskem, lokalnem in globalnem okolju«, ki smo jo na Pedagoškem inštitutu izvedli v okviru Letnega delovnega načrta Ministrstva za izobraževanje, znanost in šport Republike Slovenije v letih 2021 in 2022. Pričujoče delo s poglobljeno analizo globalnih kompetenc slovenskih učencev in učenk prispeva k znanstvenim razpravam na tem področju, hkrati pa želi v strokovni javnosti in pri oblikovalcih izobraževalnih politik podkrepiti zavedanje o pomenu globalnih kompetenc za uspešnost posameznika in celotne družbe.
Keywords: vzgoja, izobraževanje, globalne kompetence, mednarodne raziskave, PISA
Published in DiRROS: 08.07.2025; Views: 608; Downloads: 395
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Keywords: vzgoja in izobraževanje, raziskava PISA, umetna inteligenca v izobraževanju, uporaba UI pri pouku, pedagoški vpliv UI, percepcije učiteljev
Published in DiRROS: 27.01.2025; Views: 1013; Downloads: 517
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Keywords: pISA-tree, ISA model, data management, research data, metadata
Published in DiRROS: 05.06.2024; Views: 1438; Downloads: 1149
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