Iskanje po repozitoriju

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Povzetek: The outbreak of COVID-19 pandemic in Kosovo increased citizens’ need to use open public spaces. This paper aims to investigate the importance of open public spaces in social life, and how much citizens in Kosovo used them before and during the pandemic. The study is conducted during the quarantine period (2020), through a questionnaire (N = 549) with the use of the Microsoft Forms online tool, and it involved citizens over 18 years old, from over 58 percent of municipalities from all over Kosovo. The results of the study show that during the quarantine period only 20.5% of citizens frequented public spaces every day, and that citizens mostly used them for recreation (26%), meeting with relatives or friends (31%), sports activities (23%), work and other purposes (20%). However, the fear of COVID-19 and the observance of restrictions on movement meant that 24% of citizens did not use open public spaces. Being in open public spaces gave citizens feelings of satisfaction, curiosity, optimism, and calm, and strengthened their self-confidence. Quarantine significantly increased the awareness of citizens about the lack of open public spaces in their neighbourhoods.
Ključne besede: COVID-19, public spaces, social life, quarantine, Kosovo
Objavljeno v DiRROS: 08.07.2026; Ogledov: 79; Prenosov: 62
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Povzetek: This study examines conspiratorial beliefs associated with the coronavirus pandemic in the United States, the European Union, and Slovenia. Drawing on a case-based approach, this research seeks to understand the underlying factors that have led to the emergence of conspiratorial beliefs regarding the coronavirus and the COVID-19 disease. We analysed surveys from the US and the EU to investigate the support of the general population towards the selected statements and beliefs closely connected to prevailing conspiracy theories. We seek the answer to the question of which demographic and societal factors contribute the most towards people’s beliefs about the origins of coronavirus.
Ključne besede: Covid-19, conspiracy theories, beliefs, United States, European Union, Slovenia
Objavljeno v DiRROS: 01.07.2026; Ogledov: 106; Prenosov: 80
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Povzetek: Background Paediatric patients with autoimmune rheumatic diseases (pARD) have a dysregulated immune system, so infections present a major threat to them. To prevent severe COVID-19 infections we aimed to vaccinate them as soon as possible. Studies have shown that the BNT162b2 vaccine is safe, effective, and immunogenic, however, in a short observation period, only. Methods The main objective was to compare the serological response between three groups of pARD: after SARSCoV-2 infection, after vaccination against COVID-19 with two doses of the BNT162b2 vaccine, and after experiencing both events. Data on demographics, diagnosis, therapy, and serology (anti-SARS-CoV-2 IgG/IgA) were collected from March 2020 to April 2022. For statistical analysis ANOVA, Mann-Whitney U test, Chi-square test and Fisher’s exact test were applied. To compare adverse events (AE) after vaccination we included a control group of healthy adolescents. Results We collected data from 115 pARD; from 92 after infection and 47 after vaccination. Twenty-four were included in both groups. Serological data were available for 47 pARD after infection, 25 after vaccination, and 21 after both events. Serological response was better after vaccination and after both events compared to after infection only. No effect of medication on the antibody levels was noted. The safety profile of the vaccine was good. Systemic AE after the first dose of the vaccine were more common in healthy adolescents compared to pARD. In the observation period of 41.3 weeks, 60% of vaccinated pARD did not experience a symptomatic COVID-19 infection. Conclusions IgG and IgA anti-SARS-CoV-2 levels were higher after vaccination and after both events compared to after infection only. Six months after vaccination we observed an increase in antibody levels, suggesting that pARD had been exposed to SARS-CoV-2 but remained asymptomatic.
Ključne besede: covid-19, vaccination, efficacy, paediatric autoimmune rheumatic diseases
Objavljeno v DiRROS: 16.06.2026; Ogledov: 153; Prenosov: 118
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Povzetek: Background The COVID-19 pandemic raised concern amongst clinicians that disease-modifying therapies (DMT), particularly anti-CD20 monoclonal antibodies (mAb) and fngolimod, could worsen COVID-19 in people with multiple sclerosis (pwMS). This study aimed to examine DMT prescribing trends pre- and post-pandemic onset. Methods A multi-centre longitudinal study with 8,771 participants from MSBase was conducted. Two time periods were defned: pre-pandemic (March 11 2018–March 10 2020) and post-pandemic onset (March 11 2020–11 March 2022). The association between time and prescribing trends was analysed using multivariable mixed-efects logistic regression. DMT initiation refers to frst initiation of any DMT, whilst DMT switches indicate changing regimen within 6 months of last use. Results Post-pandemic onset, there was a signifcant increase in DMT initiation/switching to natalizumab and cladribine [(Natalizumab-initiation: OR 1.72, 95% CI 1.39–2.13; switching: OR 1.66, 95% CI 1.40–1.98), (Cladribine-initiation: OR 1.43, 95% CI 1.09–1.87; switching: OR 1.67, 95% CI 1.41–1.98)]. Anti-CD20mAb initiation/switching decreased in the year of the pandemic, but recovered in the second year, such that overall odds increased slightly post-pandemic (initiation: OR 1.26, 95% CI 1.06–1.49; Switching: OR 1.15, 95% CI 1.02–1.29. Initiation/switching of fngolimod, interferon-beta, and alemtuzumab signifcantly decreased [(Fingolimod-initiation: OR 0.55, 95% CI 0.41–0.73; switching: OR 0.49, 95% CI 0.41–0.58), (Interferon-gamma-initiation: OR 0.48, 95% CI 0.41–0.57; switching: OR 0.78, 95% CI 0.62–0.99), (Alemtuzumab-initiation: OR 0.27, 95% CI 0.15–0.48; switching: OR 0.27, 95% CI 0.17–0.44)]. Conclusions Post-pandemic onset, clinicians preferentially prescribed natalizumab and cladribine over anti-CD20 mAbs and fngolimod, likely to preserve efcacy but reduce perceived immunosuppressive risks. This could have implications for disease progression in pwMS. Our fndings highlight the signifcance of equitable DMT access globally, and the importance of evidence-based decision-making in global health challenges.
Ključne besede: multiple sclerosis, covid-19, disease-modifying therapy
Objavljeno v DiRROS: 12.06.2026; Ogledov: 177; Prenosov: 112
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Povzetek: Determining the genetic contribution of susceptibility to severe SARS-CoV-2 infection outcomes is important for public health measures and individualized treatment. Through intense research on this topic, several hundred genes have been implicated as possibly contributing to the severe infection phenotype(s); however, the findings are complex and appear to be population- dependent. We aimed to determine the contribution of human rare genetic variants associated with a severe outcome of SARS-CoV-2 infections and their burden in the Slovenian population. A panel of 517 genes associated with severe SARS-CoV-2 infection were obtained by combining an extensive review of the literature, target genes identified by the COVID-19 Host Genetic Initiative, and the curated Research COVID-19 associated genes from PanelApp, England Genomics. Whole genome sequencing was performed using PCR-free WGS on DNA from 60 patients hospitalized due to severe COVID-19 disease, and the identified rare genomic variants were analyzed and classified according to the ACMG criteria. Background prevalence in the general Slovenian population was determined by comparison with sequencing data from 8025 individuals included in the Slovenian genomic database (SGDB). Results show that several rare pathogenic/likely pathogenic genomic variants in genes CFTR, MASP2, MEFV, TNFRSF13B, and RNASEL likely contribute to the severe infection outcomes in our patient cohort. These results represent an insight into the Slovenian genomic diversity associated with a severe COVID-19 outcome.
Ključne besede: severe COVID-19, severe outcome of SARS-CoV-2 infection, whole-genome sequencing, genetic susceptibility, rare variants, human rare genomic variants
Objavljeno v DiRROS: 11.06.2026; Ogledov: 211; Prenosov: 180
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