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Povzetek: This study examined whether cardiopulmonary exercise test (CPET) performanceparameters are associated with chronic cancer-related fatigue in patients receivingimmunotherapy checkpoint inhibitors (ICI) and healthy controls. Also, thedifferences in energy expenditure of steady-state cycling and gross efficiency wereassessed during submaximal cycling efforts. This study involved patients (n = 19,48 ± 13 years) receiving PD-1, PD-L1 checkpoint inhibitors and controls of similarage (n = 21, 49 ± 17 years). During the first visit, data on medical history, previousphysical activity records, and CPET to voluntary exhaustion were collected.The second visit involved body composition assessment, the MFI-20 fatiguequestionnaire, and 30-min steady-state cycling at 90% gas exchange threshold.There were no significant differences observed between the groups in age, stature,BMI, or resting blood pressure. Peak V̇O2 was 33% lower, and the group under ICItreatment had lower cycling efficiency (22.49% vs. 20.07%, p = 0.031), comparedto controls. All self-reported fatigue items derived from MFI-20 were significantlyhigher in the ICI group compared to controls (p = 0.001). The regression analysisfound no association between the self-reported general fatigue and data collectedduring CPET. Patients under ICI treatment reported higher levels of chronicfatigue, lower peak V̇O2, and reduced cycling efficiency. Interestingly, variablescollected during CPET did not explain self-reported chronic fatigue, underlyingthe complexity of this phenomenon
Ključne besede: cardiotoxicity, immune system regulation, metabolic cost of cycling
Objavljeno v DiRROS: 03.09.2026; Ogledov: 145; Prenosov: 120
Celotno besedilo (1,18 MB)
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Povzetek: Minimally invasive parathyroidectomy is the treatment of choice in patients with primary hyperparathyroidism (PHP), but it needs a reliable preoperative localization method to detect hyperfunctioning parathyroid tissue. Higher sensitivity and lower radiation exposure was demonstrated for [18F]fluorocholine PET/CT (FCh-PET/CT) in comparison to [99mTc]sestamibi (MIBI) scintigraphy. However, data of its efficiency in resource use and patient outcomes is lacking. The aim of our study was to determine the resource efficiency and patient outcomes of FCh-PET/CT in comparison to conventional MIBI scintigraphy. Patients and methods A group of 234 patients who underwent surgery after MIBI scintigraphy was compared to a group of 163 patients who underwent surgery after FCh-PET/CT. The whole working process from the implementation of imaging to the completion of surgical treatment was analyzed. The economic burden was expressed in the time needed for the required procedures. Results The time needed to perform imaging was reduced by 83% after FCh-PET/CT in comparison to MIBI scintigraphy. The time needed to perform surgery was reduced by 41% when intraoperative parathyroid hormone monitoring was not used. There was no significant difference in the time of surgery between FCh-PET/CT and MIBI scintigraphy. Conclusions FCh-PET/CT reduces the time of imaging, the time of surgery and potentially reduces the number of reoperations for persistent disease.
Ključne besede: hyperparathyroidism, parathyroidectomy, cost-effectiveness
Objavljeno v DiRROS: 26.06.2026; Ogledov: 302; Prenosov: 102
Celotno besedilo (1,70 MB)

Povzetek: In this work we consider two rich subclasses of weighted automata over fields: polynomially ambiguous weighted automata and copyless cost register automata. Primarily we are interested in understanding their expressiveness power. Over the field of rationals and 1-letter alphabets, it is known that the two classes coincide; they are equivalent to linear recurrence sequences (LRS) whose exponential bases are roots of rationals. We develop a tool we call Pumping Sequence Families, which, by exploiting the simple single-letter behaviour of the models, yields two pumping-like results over arbitrary fields with unrestricted alphabets, one for each class. As a corollary of these results, we present examples proving that the two classes become incomparable over the field of rationals with unrestricted alphabets. We complement the results by analysing the zeroness and equivalence problems. For weighted automata (even unrestricted) these problems are well understood: there are polynomial time, and even NC$^2$ algorithms. For copyless cost register automata we show that the two problems are PSpace-complete, where the difficulty is to show the lower bound.
Ključne besede: weighted automata, cost register automata, ambiguity, linear recurrence sequences, equivalence problem
Objavljeno v DiRROS: 18.05.2026; Ogledov: 351; Prenosov: 205
Celotno besedilo (1,21 MB)
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Ključne besede: delivery strategies, European cooperation in science and technology, COST, GenE-HumDi, genome editing, base editors, delivery systems, regulatory guidelines
Objavljeno v DiRROS: 29.08.2025; Ogledov: 1193; Prenosov: 575
Celotno besedilo (4,29 MB)
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Povzetek: Wood is considered a promising raw material for the circular bioeconomy and has the ability to store biogenic carbon, and this is one reason why we want to extend the service life of the wood. In order to consider the influence of durability in our study, we used two wood species with different lifespans. Beech (Fagus sylvatica L.) belongs to the group of very sensitive wood species, as the durability of the untreated wood is estimated to be around 5 years; meanwhile, pine (Pinus sylvestris L.) belongs to the group of moderately resistant wood species, where the durability of the untreated wood is estimated to be up to 15 years. While toxic chemicals are often used for wood preservation, hydroxyapatite offers an environmentally friendly solution for wood mineralization. This study presents life cycle assessment (LCA) and life cycle cost (LCC) analyses comparing a novel hydroxyapatite (HAp) mineralization method with a service life of 50 years to a non-mineralized reference alternative. LCA was based on EN ISO 14040 and EN ISO 14044, while LCC was adapted from the European Commission’s LCC tool for public procurement. The results of the LCA show that mineralized wood has a lower overall impact on the environment than surface-treated beech wood but a higher impact than surface-treated pine wood. Most impact categories were determined by electricity consumption with the exception of stratospheric ozone depletion, water consumption, and land use. Water consumption proved to be the category where the mineralization process was problematic due to water consumption during the leaching process. The LCC showed that mineralized wood is the most cost-effective solution for the exterior façade, as all costs, but especially investment costs, were lower. The differences in the LCA and LCC results are mainly due to the different lifetimes of the two alternatives. It can be concluded that if energy-intensive processes and chemicals are used in the production of the material, the extended lifetime must be sufficient to account for the additional impacts that occur during the production phase.
Ključne besede: environmental impacts, hydroxyapatite, life cycle assessment (LCA), life cycle cost analysis (LCC), wood mineralization
Objavljeno v DiRROS: 09.09.2024; Ogledov: 1639; Prenosov: 3437
Celotno besedilo (2,60 MB)
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