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Query: "author" (Vrankar Martina) .

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1.
Priporočila za obravnavo bolnikov s pljučnim rakom
Martina Vrankar, Nina Boc, Izidor Kern, Aleš Rozman, Karmen Stanič, Tomaž Štupnik, Mojca Unk, Maja Ebert Moltara, Vesna Zadnik, Katja Adamič, Jernej Benedik, Marko Bitenc, Jasna But-Hadžić, Anton Crnjac, Marina Čakš, Dominik Časar, Eva Ćirić, Tanja Čufer, Ana Demšar, Rok Devjak, Goran Gačevski, Marta Globočnik Kukovica, Kristina Gornik-Kramberger, Maja Ivanetič Pantar, Marija Ivanović, Urška Janžič, Staša Jelerčič, Veronika Kloboves-Prevodnik, Mile Kovačević, Luka Ležaič, Mateja Marc-Malovrh, Katja Mohorčič, Loredana Mrak, Igor Požek, Nina Turnšek, Bogdan Vidmar, Dušanka Vidovič, Gregor Vlačić, Ana Lina Vodušek, Rok Zbačnik, Ivana Žagar, 2023, professional article

Abstract: Leta 2019 so bila objavljena Priporočila za obravnavo bolnikov s pljučnim rakom, ki so v slovenski prostor vnesla prepotrebno poenotenje diagnostike in zdravljenja z namenom izboljšanja preživetja bolnikov s pljučnim rakom. Posodobitev Priporočil tri leta po izidu izvirnika prinaša največ novosti v poglavju o sistemskem zdravljenju bolnikov s pljučnim rakom. To kaže na izjemen napredek na področju razumevanja onkogeneze in biologije pljučnega raka ter s tem razvoja novih zdravil. Breme pljučnega raka ostaja veliko, saj je pljučni rak pri nas in v svetu še vedno najpogostejši vzrok smrti zaradi raka. Za vsako peto smrt zaradi raka je odgovoren pljučni rak. Skoraj tretjina bolnikov s pljučnim rakom ne prejme specifičnega onkološkega zdravljenja, bodisi zaradi slabega stanja zmogljivosti, spremljajočih bolezni ali obsega bolezni. Polovica bolnikov ima ob diagnozi razsejano bolezen, zaradi česar izboljšanje preživetja z malimi koraki sledi napredku v zdravljenju bolnikov s pljučnim rakom. Ti podatki nas opominjajo, da se bomo morali za velike premike v obravnavi bolnikov s pljučnim rakom lotiti drugačnih pristopov. Kot najbolj obetavno se ponuja zgodnje odkrivanje bolezni, ko so možnosti ozdravitve pljučnega raka najboljše. Zapisana Priporočila so usmeritev za obravnavo bolnikov s pljučnim rakom. Le s sodobnim multidisciplinarnim pristopom obravnave lahko bolniku ponudimo zdravljenje, ki mu omogoča najboljši izhod prognostično neugodne bolezni.
Keywords: pljučni rak, priporočila
Published in DiRROS: 27.07.2023; Views: 371; Downloads: 129
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2.
Fizikalni modeli imunoterapije in radioterapije
Damijan Valentinuzzi, Martina Vrankar, Katja Uršič Valentinuzzi, Mojca Unk, Olga Gordeeva, Alen Hadžić, Gregor Serša, Maja Čemažar, Robert Jeraj, 2023, published scientific conference contribution

Abstract: V prispevku bomo predstavili rezultate fizikalnih modelov imunoterapije, ki smo jih razvili v programski skupini Medicinska fizika na Fakulteti za matematiko in fiziko Univerze v Ljubljani. Glavni cilj raziskav je bila prepoznava bioloških značilnosti tumorjev, od katerih je odvisen odziv na zdravljenje s protitelesi receptorja programirane celične smrti l (angl. anti-programmed-death-1 (anti-PD-1)). Posebno pozornost smo namenili meritvam modelskih parametrov ter preverbi rezultatov modeliranja, kar je eden izmed predpogojev za uspešno translacijo modeliranja v rutinsko predklinično in klinično prakso. Predstavili bomo tudi načrte za prihodnost, tj. modeliranje kombinacije anti-PD-1 in radioterapije.
Keywords: imunoterapija, radioterapija, medicinska fizika, tumorji
Published in DiRROS: 16.06.2023; Views: 340; Downloads: 93
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3.
Četrta šola pljučnega raka : zbornik
2023, proceedings of professional or unreviewed scientific conference contributions

Published in DiRROS: 12.05.2023; Views: 533; Downloads: 115
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4.
Pljučni rak - nacionalni problem
Martina Vrankar, 2023, published scientific conference contribution

Abstract: Breme pljučnega raka v Sloveniji v zadnjem desetletju ostaja nacionalni problem. Incidenčna stopnja se je pri moških sicer ustalila v zadnjih nekaj desetletjih, podatki pri ženskah pa kažejo na strm porast incidence v zadnjem desetletju, saj vsako leto zboli za skoraj 6 % več žensk. Kar dobra polovica bolnikov s pljučnim rakom ima ob diagnozi razsejan pljučni rak, ki ga kljub sodobnim načinom zdravljenja ne moremo pozdraviti. Po umrljivosti je pljučni rak pri moških in pri ženskah na prvem mestu. Vsako peto smrt zaradi raka pripišemo pljučnemu raku. Petletno preživetje bolnikov, zbolelih v obdobju 2015–2019, je bilo 19,5 %, bolnic pa 26,4 %. Izzivi v prihodnosti so v zgodnejšem odrivanju pljučnega raka. Raziskave so pokazale, da lahko presejanje pljučnega raka zniža umrljivost za 20 %, saj omogoča odkrivanje zgodnjih oblik raka. V presejalni program pljučnega raka morajo biti vključeni učinkoviti programi za opuščanje kajenja, prav tako pa je potrebno intenzivirati aktivnosti primarne preventive.
Keywords: pljučni rak, onkološko zdravljenje, bolniki
Published in DiRROS: 12.05.2023; Views: 249; Downloads: 149
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Vloga radiomike v napovedovanju učinkovitosti zdravljenja z imunoterapijo pri bolnikih z rakom pljuč
Martina Vrankar, Damijan Valentinuzzi, Nina Boc, Mojca Unk, 2021, published scientific conference contribution

Keywords: rak pljuč, radiomika, imunoterapija
Published in DiRROS: 04.04.2022; Views: 551; Downloads: 185
.pdf Full text (293,52 KB)

7.
Naše izkušnje kombinirane terapije pri bolnikih z nedrobnoceličnim pljučnim rakom stadija III
Martina Vrankar, 2021, published professional conference contribution

Keywords: imunoterapija, radioterapija, onkološko zdravljenje
Published in DiRROS: 29.03.2022; Views: 426; Downloads: 214
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8.
PD-L1 expression can be regarded as prognostic factor for survival of non-small cell lung cancer patients after chemoradiotherapy
Martina Vrankar, Matjaž Zwitter, Izidor Kern, Karmen Stanič, 2018, original scientific article

Abstract: The standard treatment for inoperable locally advanced non-small cell lung cancer (LA NSCLC) includes concurrent or sequential chemotherapy (ChT) and radiation therapy (RT). Long term survival rates with these approaches remains only in the order of 15%, therefore new treatment strategies, including immunotherapy, are under investigation, with programmed death ligand-1 (PD-L1) as one of the major players. We evaluated the clinical significance of PD-L1 expression in tumor samples from patients with inoperable LA NSCLC who underwent concurrent chemoradiotherapy (CRT) in our institution between 2005 and 2010 and correlated their expression with clinicopathological parameters and outcome of treatment. Among 107 patients treated with concurrent CRT, a total of 43 (36 males and 7 females) had sufficient tissue for immunohistochemical (IHC) staining. The expression of PD-L1 was demonstrated in 7 tumors, in 6 males and 1 female. No statistical significant differences in patient characteristics, including age, smoking status and gender, were found according to the PD-L1 expression. After a median follow up of 103.6 months, median progression free survival (PFS) was 19.9 months in patients without and 10.1 months in patients with PD-L1 expression (p=0.008). Median overall survival (OS) was 28.4 and 12.1 months for PD-L1 negative and PD-L1 positive patients, respectively (p=0.012). In conclusions, patients with PD-L1 expression had shorter PFS and OS after concurrent CRT in LA NSCLC. Unfortunately, only small number of patients had tissue available for the IHC testing, therefore no firm conclusions could be made and further investigation is warranted.
Keywords: non-small cell lung cancer, lung cancer, chemoradiotherapy, survival
Published in DiRROS: 17.12.2020; Views: 1310; Downloads: 413
URL Link to file

9.
Prognostic value of PD-L1 expression in patients with unresectable stage III non-small cell lung cancer treated with chemoradiotherapy
Martina Vrankar, Izidor Kern, Karmen Stanič, 2020, original scientific article

Abstract: Background: Expression of PD-L1 is the most investigated predictor of benefit from immune checkpoint blockade in advanced NSCLC but little is known about the association of PD-L1 expression and clinicopathological parameters of patients with unresectable stage III NSCLC. Methods: National registry data was searched for medical records of consecutive inoperable stage III NSCLC patients treated with ChT and RT from January 2012 to December 2017. Totally 249 patients were identified that met inclusion criteria and of those 117 patients had sufficient tissue for PD-L1 immunohistochemical staining. Results: Eighty patients (68.4%) expressed PD-L1 of >- 1% and 29.9% of more than 50%. Median PFS was 15.9 months in PD-L1 negative patients and 16.1 months in patients with PD-L1 expression >- 1% (p = 0.696). Median OS in PD-L1 negative patients was 29.9 months compared to 28.5 months in patients with PD-L1 expression >- (p = 0.888). There was no difference in median OS in patients with high PD-L1 expression (>- 50%) with 29.8 months compared to 29.9 months in those with low (1-49%) or no PD-L1 expression (p = 0.694). We found that patients who received a total dose of 60 Gy or more had significantly better median OS (32 months vs. 17.5 months, p < 0.001) as well as patients with PS 0 (33.2 vs. 20.3 months, p = 0.005). Conclusions: In our patients PD-L1 expression had no prognostic value regarding PFS and OS. Patients with good performance status and those who received a total radiation dose of more than 60 Gy had significantly better mOS.
Keywords: non small cell lung cancer, chemoradiotherapy, stage III
Published in DiRROS: 09.11.2020; Views: 1397; Downloads: 1001
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