1. Exploring marine microbial diversity : an overview of representative sampling strategiesZrinka Ljubešić, Marija Gligora Udovič, Donata Overlingė, Filip Grgurević, Füsun Akgül, Ariola Bacu, Ana R. Díaz Marrero, Dragana Drakulović, Stefano Fazi, Susana P. Gaudêncio, Anamarija Kolda, Lucie Novoveská, Ivo Safarik, Joana Sousa, Olivier Thomas, Maggie M. Reddy, Giovanna Cristina Varese, Marlen Ines Vasquez, Tihomir Makovec, Ana Rotter, 2025, pregledni znanstveni članek Ključne besede: biodiscovery, marine microbial diversity, sampling protocol, sample preservation and storage, biorepositories, cultures, marine biology
Objavljeno v DiRROS: 17.10.2025; Ogledov: 172; Prenosov: 72
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2. A contribution to the vascular and bryophyte flora of the upper Neretva and Zalomka river valleys (Bosnia and Herzegovina)Đorđije Milanović, Simona Strgulc Krajšek, Jugoslav Brujić, Valentin Heimer, Dragan Koljanin, Marija Kravanja, Ivana Rešetnik, Vladimir Stupar, Peter Schönswetter, Božo Frajman, 2025, izvirni znanstveni članek Povzetek: etween 1st and 6th June 2023, we conducted floristic research on sev-eral sites in the upper Neretva River valley and along Zalomka River at Nevesinjsko Polje. We recorded 933 taxa in total; 897 plant taxa including 125 bryophytes were found at 51 localities in the upper Neretva River val-ley, and 200 plant taxa, including 32 bryophytes, were found at 11 sites in the Zalomka River valley. Among the registered taxa, 39 taxa are endemic to the Balkan Peninsula, 56 are listed in the List of endangered and rare taxa of Bosnia and Herzegovina, 27 are on the Red List of the Federation of Bosnia and Herzegovina, and 95 taxa are protected in the Republic of Srpska. We also registered several species new to the flora of Bosnia and Herzegovina. Among Angiosperms these were Barbarea intermedia, Lamium hybridum, Myosotis sicula and Poa ursina, and among bryophytes Fissidens gracilifolius, Grimmia dissimulata, Plagiomnium ellipticum, Schistidium robustum, Sphenolobus minutus, Tortella fasciculata and T. pseudofragilis. Our study reveals the high nature conservation value of the upper Neretva and Zalomka River valleys that should be protected for future generations. In addition, further systematic research of the flora of Bosnia and Herzegovina is needed
Ključne besede: angiosperms, mosses, nature conservation, Neretva River, vegetation, are species
Objavljeno v DiRROS: 16.10.2025; Ogledov: 158; Prenosov: 73
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3. Navodila za ravnanje s smrekovimi sečnimi ostanki za preprečevanje prenamnožitev podlubnikovMaarten De Groot, Tine Hauptman, Luka Capuder, Simon Zidar, Marija Kolšek, 2025, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid Ključne besede: sečni ostanki, podlubniki, gozdnogojitveni preprečevalni ukrepi
Objavljeno v DiRROS: 01.10.2025; Ogledov: 349; Prenosov: 155
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5. Water-based pharmacophore modeling in kinase inhibitor design : a case study on fyn and lyn protein kinasesMartin Ljubič, Marija Sollner Dolenc, Jure Borišek, Andrej Perdih, 2025, izvirni znanstveni članek Povzetek: Water-based pharmacophore modeling is an emerging approach in inhibitor design that leverages the dynamics of explicit water molecules within ligand-free, water-filled binding sites to derive 3D pharmacophores for virtual screening. In this study, we assess the potential of this strategy through a case study targeting the ATP binding sites of Fyn and Lyn protein kinases─members of the Src family that have been less explored in anticancer drug discovery compared to other family members. Molecular dynamics simulations of multiple kinase structures were used to generate and validate several water-derived pharmacophores, which were subsequently employed to screen chemically diverse libraries of compounds. Two active compounds were identified in biochemical assays: a flavonoid-like molecule with low-micromolar inhibitory activity and a weaker inhibitor from the library of nature-inspired synthetic compounds. Structural analysis via molecular docking and simulations revealed that key predicted interactions, particularly with the hinge region and the ATP binding pocket, were retained in the bound states of these hits. However, interactions with more flexible regions, such as the N-terminal lobe and activation loop, were less consistently captured. These findings outline both the strengths and challenges of using water-based pharmacophores: while effective at modeling conserved core interactions, they may miss peripheral contacts governed by protein flexibility. Incorporating ligand information where available may help address this challenge. Overall, water-based pharmacophore modeling presents a promising ligand-independent strategy for identifying novel chemotypes and exploring undercharged chemical and conformational space in kinases as well as other therapeutically relevant targets.
Ključne besede: drug discovery, inhibitors, ligands, peptides, proteins, pharmacophores
Objavljeno v DiRROS: 23.09.2025; Ogledov: 205; Prenosov: 108
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8. Temozolomid pri zdravljenju bolnikov z možganskim tumorjem : bolnikov dnevnikUroš Smrdel, Lorna Zadravec-Zaletel, Marija Skoblar Vidmar, Gregor Kos, Ana Lina Vodušek, 2024, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid Ključne besede: rak glave, temozolomid, možganski tumorji, bolniki
Objavljeno v DiRROS: 03.09.2025; Ogledov: 300; Prenosov: 71
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9. Temozolomid pri zdravljenju bolnikov z možganskim tumorjem : bolnikov dnevnikUroš Smrdel, Lorna Zadravec-Zaletel, Marija Skoblar Vidmar, Gregor Kos, Ana Lina Vodušek, 2015, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid Ključne besede: rak glave, temozolomid, možganski tumorji, bolniki
Objavljeno v DiRROS: 02.09.2025; Ogledov: 243; Prenosov: 61
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10. Prostorska razpršenost stanovanjskih enot kot pomemben dejavnik vpliva na stroške dolgotrajne oskrbeNorina Szander, Lorenzo Ros McDonnell, Marija Bogataj, 2017, izvirni znanstveni članek Povzetek: Več kot 90 % starostnikov bi se rado postaralo tam, kjer živijo. To idejo podpirajo tudi strateški načrti Evropskega semestra za dolgotrajno oskrbo (ang. European semesters on long-term care) za države članice, vendar ne vključujejo dovolj inovacij, da bi resnično izboljšali življenjske razmere starejših z ustrezno opremljenim okoljem in vzdržnim financiranjem. Prostorsko razpršenost stanovanj in gostoto poselitve v funkcionalnem območju bi morala pri načrtovanju grajenega okolja in drugih objektov za starejše posebej upoštevati vodstva ustanov, ki starejšim zagotavljajo namestitev, zdravstveno oskrbo in druge storitve, saj so cene logistike (prevoz materiala, delovna sila, prevoz starostnikov v dnevne programe itd.) precej odvisne od teh dveh dejavnikov. Na podlagi podatkov doma za ostarele v eni od madžarskih občin smo ocenili in optimizirali načrtovanje poti ter razporejanje za potrebe oskrbe starostnikov na domu glede na različne možne prostorske razporeditve in z različno gostoto strank. Poti negovalnega osebja, ki oskrbuje starostnike, smo simulirali s problemom trgovskega potnika (ang. multiple travelling salesman, mTSP), rešitve pa navajajo potrebno delovno silo in časovne zahteve za opravljanje storitev. Orodje, ki nam je omogočilo proučiti izide različnih možnosti, bi lahko tudi stroki pomagalo pri predvidevanju in načrtovanju prihodnjih sprememb pri stroških dolgotrajne oskrbe zaradi vse večjega števila starejših, ki bodo pri ohranjanju samostojnosti potrebovali pomoč, spreminjata pa se tudi gostota in razpršenost gospodinjstev.
Ključne besede: stanovanja, dolgotrajna oskrba, prostorska razpršenost, funkcionalna regija
Objavljeno v DiRROS: 12.08.2025; Ogledov: 379; Prenosov: 175
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