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12. Effect of the type of application of Newcastle disease virus on the Ehrlich ascites tumorTomaž Milanez, Robert Košak, Anton Cerar, 1996, izvirni znanstveni članek Povzetek: Newcastle disease virus (NDV) has been shown to have an inhibitory effect on the tumours. Most authors use peritumoral application of virus. The purpose of our studz was to compare the effects of the ip in contrast to sc application of the virus on the ip and sc transplanted Ehrlich ascites tumor (EAT) in CBA/H mouse. We measured the length of survival, the tumor cure rates, the metastatic rate, and the frequencz of ascites and sc tumors in the site of ip EAT injection. Prolongation of survival after the therapy with NDV in ip transplanted EAT average time of survival in control group was 70.5 days, and 107 and 79.9 days with ip and sc NDV virus therapy respectively. The differences were significant only between control group and the group treated with ip application of NDV. Tumor cure rates were: ipNDV group 30%, scNDV group 20% and control group 5%. NDV therapy in sc transplanted EAT prolonged the time of survival; in control group it was 63.3 days, and 75.2 and 65.9 days with ip and sc NDV therapy respectively. NDV therapy inhibited metastatic rate of ip transplanted EAT. Inhibition was more effective with ip application of NDV. VIrus therapz also lowered the frequencz of appearance of ascites and sc tumour in the site of ip EAT injevtion. In sc transplanted EAT ip application of NDV inhibited the metastatic rate while in sc applied NDV some stimulation of metastasation was found. Ip application of NDV was found to be superior in contrast to sc application in all its therapeutic effects against EAT. Our results show that the tumor inhibition of NDV, in the system we used, has the characteristics of the biological response modifiers. Objavljeno v DiRROS: 16.01.2024; Ogledov: 126; Prenosov: 35 Celotno besedilo (384,33 KB) |
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14. Multivariate statistical methods in determining the spatial distribution of chemical elements in soil from the Mavrovo-Rostuše region, North MacedoniaTrajče Stafilov, Robert Šajn, Kristina Petrovska, 2023, izvirni znanstveni članek Povzetek: In this work, the contents and spatial distributions of 19 elements (Ag, Al, B, Ba, Ca, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Ni, P, Pb, Sr, V, Zn) in the soil of the western part of North Macedonia (Mavrovo-Rostuše region) are presented. For this purpose, a total of 66 soil samples were collected from 33 locations (33 samples of topsoil, 0-5 cm, and 33 samples of subsoil, 20-30 cm). All samples were analysed by inductively coupled plasma - atomic emission spectrometry (ICP-AES) after complete digestion with four acids (HNO3, HF, HClO4 and HCl). The obtained results were statistically evaluated and spatial distribution maps for all analysed elements were also prepared. Factor analysis was performed to reduce the number of data used and new synthetic variables (factors) were identified. Through the application of factor analysis, three geochemical associations were identified: Factor 1 (Zn, K, Cu, Fe, and Li), Factor 2 (Cr, Ni, and Mg) and Factor 3 (Ca and Al). From the obtained data and the maps of spatial distribution, it could be concluded that the distribution of the analysed elements is related to the lithology of the region. Thus, it was found that the higher content of elements of Factor 1 occurs in the eastern and southern part of the study area (middle and lower reaches of the Radika River and along the Mala River), where Mesozoic and Paleozoic carbonates as well as Paleozoic shales and Paleogene flysch prevail. Factor 2 (Cr, Ni and Mg) also represents a lithogenic association. The highest contents of the elements in both soil layers were found in the areas where Paleozoic sandstones and shales (village of Lazaropole and the area around the Mavrovo Lake) and Paleogene flysch (Rostuše village) predominate. Factor 3 (Ca and Al) also represents lithogenic association of elements. The highest content of these elements was found in the northwestern part of the study area (village of Žirovnica and along the Berička River) and in the northeastern region above the village of Brodec where Mesozoic carbonates and Paleogene flysch dominate. Ključne besede: soil, heavy metals, spatial distribution, Mavrovo-Rostuše region, North Macedonia Objavljeno v DiRROS: 04.01.2024; Ogledov: 173; Prenosov: 41 Celotno besedilo (1,90 MB) |
15. Application of multivariate statistical methods for determining geochemical trends of elements on the territory of SloveniaRobert Šajn, Mateja Gosar, Jasminka Alijagić, Tamara Teršič, 2024, izvirni znanstveni članek Povzetek: The main objective of this study is to map multi-element geochemical anomalies in soil on a regional scale. We aimed to determine and evaluate the baseline geochemical values and main geochemical trends in soil that may serve as reference values against any future changes. A total of 817 topsoil samples (0–10 cm) were collected in a 5 × 5 km grid and analyzed for 35 elements using ICP-ES after multi-acid digestions (HClO4/HNO3/HCl/HF) and 53 elements using ICP-MS after modified aqua regia digestion (HCl/HNO3/H2O). The analytical results for the two different digestion methods (multi-acid digestion vs. aqua regia) were also compared for each chemical element. Multivariate statistical methods were applied to identify the geochemical trends and main sources of trace elements over the territory of Slovenia. Based on these results, seven natural and one mixed natural/anthropogenic geochemical association were established. The contents and trends of the determined factors are presented according to 8 natural units, 4 drainage areas, and geological units characteristic of Slovenia. The identified anthropogenic geochemical association combines toxic elements (Ag, Bi, Cd, Hg, P, Pb, S, Sn, and Zn). Increased values of these elements can be found in mining areas and metallurgic centers, in Quaternary sediments of the Sava River, and Adriatic Basin as the consequence of past mining activities and in the Julian Alps, where their origin could be connected to the atmospheric deposition. Ključne besede: soil, geochemical mapping, distribution of geochemical elements, factor analysis, cluster analysis Objavljeno v DiRROS: 04.01.2024; Ogledov: 168; Prenosov: 38 Celotno besedilo (9,92 MB) |
16. Tehnične smernice za ohranjanje in rabo genskih virov : brek = Sorbus torminalisRobert Brus, Zvone Sadar, Primož Štular, Hojka Kraigher, 2013, strokovni članek Ključne besede: genski viri, drevesne vrste, tehnične smernice, brek, Sorbus torminalis, Slovenija Objavljeno v DiRROS: 20.12.2023; Ogledov: 277; Prenosov: 63 Celotno besedilo (407,93 KB) |
17. Tehnične smernice za ohranjanje in rabo genskih virov : lipa in lipovec = Tilia platyphyllos, Tilia cordataIgor Dakskobler, Robert Brus, Andrej Verlič, Nikica Ogris, Gregor Božič, 2013, strokovni članek Ključne besede: genski viri, drevesne vrste, tehnične smernice, lipa, Tilia platyphyllos, lipovec, Tilia cordata, Slovenija Objavljeno v DiRROS: 20.12.2023; Ogledov: 215; Prenosov: 0 |
18. Tehnične smernice za ohranjanje in rabo genskih virov : lesnika in drobnica = Malus sylvestris, Pyrus pyrasterMirko Perušek, Gregor Božič, Robert Brus, Hojka Kraigher, 2012, strokovni članek Ključne besede: genski viri, drevesne vrste, tehnične smernice, lesnika, Malus sylvestris, drobnica, Pyrus pyraster, Slovenija Objavljeno v DiRROS: 20.12.2023; Ogledov: 187; Prenosov: 59 Celotno besedilo (417,15 KB) |
19. Tehnične smernice za ohranjanje in rabo genskih virov : navadna in puhasta breza = Betula pendula, Betula pubescensAndrej Držaj, Robert Brus, Hojka Kraigher, 2012, strokovni članek Ključne besede: genski viri, drevesne vrste, tehnične smernice, navadna breza, puhasta breza, Betula pendula, Betula pubescens, Slovenija Objavljeno v DiRROS: 20.12.2023; Ogledov: 165; Prenosov: 52 Celotno besedilo (45,26 KB) |
20. Tehnične smernice za ohranjanje in rabo genskih virov : trepetlika in beli topol = Populus tremula, populus alba : SloveniaRobert Brus, Aleksander Marinšek, Tine Grebenc, Gregor Božič, 2012, strokovni članek Ključne besede: genski viri, drevesne vrste, tehnične smernice, trepetlika, beli topol, Populus tremula, Populus alba, Slovenija Objavljeno v DiRROS: 20.12.2023; Ogledov: 184; Prenosov: 54 Celotno besedilo (485,24 KB) |