51. Vinblastine increases antitumor effectiveness of bleomycinMaja Čemažar, Marija Auersperg, Gregor Serša, 1997, izvirni znanstveni članek Povzetek: In our previous vinblastine (VELBE) was shown to increase the plasma membrane fluidity. This effect of VELBE might be expolited for better transport of drugs through the plasma membrane. Bleomycin (BLM) is a highly cytotoxic drug when present inside the cells but has a hampered transport through the plasma membrane. The aim of the present study was to determine whether pretreatment with VELBE can increase the effect of BLM on intraperitoneal SA-1 tumors in mice. BLM and VELBE were used as single agents or in various combinations, i.e. VELBE and BLM injected simultanously, BLM injected 24 h before VELBE or VELBE injected 24 h before BLM. Mice survival was the end-point used for determining the effect of this combined treatments. VELBE and BLM as a single treatment significantly prolonged median survival time of study animals compared to controls. Furthermore, when VELBE and BLM were combined, all threetested combinations were more effective than VELBE or BLM as single treatments. The effect on animal survival was equal when VELBE was given 24 h after or simultanously with BLM. The longest survival, however was obtained when VELBE was injected 24 h before BLM. From these results we can conclude that the underlying mechanisms for more than additive effect of VELBE and BLM when VELBE was given 24 h before BLM could be attributed to an increased membrane fluidity, possibly in combination with a cell kinetic effect.
Objavljeno v DiRROS: 18.01.2024; Ogledov: 117; Prenosov: 27
 Celotno besedilo (1,28 MB) |
52. Study of blood perfusion with patent blue staining method in LPB fibrosarcoma tumors in immuno-competent and immuno-deficient mice after electrotherapy by direct currentTomaž Jarm, Dong Jian An, Jean Belehradek, Lluis M. Mir, Gregor Serša, Maja Čemažar, Tadej Kotnik, Jani Pušenjak, Damijan Miklavčič, 1997, izvirni znanstveni članek Objavljeno v DiRROS: 16.01.2024; Ogledov: 140; Prenosov: 32
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54. Electrochemotherapy with bleomycin : The first clinical experience in malignant melanoma patientsZvonimir Rudolf, Borut Štabuc, Maja Čemažar, Damijan Miklavčič, Lojze Vodovnik, Gregor Serša, 1995, izvirni znanstveni članek Ključne besede: melanoma therapy, bleomycin, electric stimulation therapy
Objavljeno v DiRROS: 15.01.2024; Ogledov: 146; Prenosov: 39
Celotno besedilo (418,42 KB) |
55. Improved therapeutic effect of electrochemotherapy with cisplatin by intratumoral drug administration and changing of electrode orientation for electropermeabilization on EAT tumor model in miceMaja Čemažar, Damijan Miklavčič, Lojze Vodovnik, Tomaž Jarm, Zvonimir Rudolf, Borut Štabuc, Tanja Čufer, Gregor Serša, 1995, izvirni znanstveni članek Ključne besede: neoplasmas, experimental therapy, cisplatin, electric stimulation therapy, cell membrane permeability
Objavljeno v DiRROS: 15.01.2024; Ogledov: 138; Prenosov: 39
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58. Perspektive obnove slovenskih gozdov v času podnebnih in družbenih spremembBoris Rantaša, Franc Perko, Gregor Božič, Marjana Westergren, Primož Simončič, Hojka Kraigher, 2023, strokovni članek Povzetek: Trajnostno, sonaravno in večnamensko gospodarjenje s slovenskimi gozdovi je omogočilo ohranjeno biotsko raznovrstnost, ohranjen prilagoditveni potencial ter velik povprečni prirastek in lesno zalogo. Za trajnostno zagotavljanje funkcij gozdov bo potrebno prilagajanje na spreminjajoče se podnebne in družbene razmere. Osrednji ukrep prilagajanja gozdov na podnebne spremembe je povečevanje pestrosti, tudi genetske. Praktično vsi področni strateški, zakonodajni ter operativni dokumenti na nacionalni in evropski ravni prepoznavajo in vsebujejo pomen ohranjanja gozdnih genskih virov in obnove ter nege gozda za trajnostni razvoj in zagotavljanje funkcij gozdov. Gospodarjenje z gozdovi bo treba nadgraditi z ukrepi, ki vključujejo aktiven pristop pri obnovi in negi gozda s čim širšo paleto vrstno in genetsko raznolikih sadik gozdnih drevesnih vrst. V obdobju 2023–2026 bo za obnovo gozdov in semenarsko ter drevesničarsko dejavnost na letni ravni potencialno namenjenih pribl. pet milijonov evrov javnih sredstev. Za obnovo in nego gozda bo nujno zagotoviti stabilno in fleksibilno financiranje zagotavljanja gozdnega reprodukcijskega materiala ter izvedbo obnove gozda in razvoja panoge. Avtorji poudarjajo tudi pomen sodelovanja in skupnega nastopa različnih deležnikov v celotni verigi gozdnega reprodukcijskega materiala.
Ključne besede: obnova gozdov, podnebne spremembe, družbene spremembe, zakonodaja, strategije, finance, Slovenija
Objavljeno v DiRROS: 09.01.2024; Ogledov: 231; Prenosov: 84
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60. A second glass transition observed in single-component homogeneous liquids due to intramolecular vitrificationBen A. Russell, Mario González-Jiménez, Nikita V. Tukachev, Laure-Anne Hayes, Tajrian Chowdhury, Uroš Javornik, Gregor Mali, Manlio Tassieri, Joy H. Farnaby, Hans Martin Senn, Klaas Wynne, 2023, izvirni znanstveni članek Objavljeno v DiRROS: 09.01.2024; Ogledov: 142; Prenosov: 74
Celotno besedilo (2,60 MB)
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