1. The influence of folate pathway polymorphisms on high-dose methotrexaterelated toxicity and survival in children with non-Hodgkin malignant lymphomaNina Erčulj, Barbara Faganel Kotnik, Maruša Debeljak, Janez Jazbec, Vita Dolžan, 2014, original scientific article Abstract: Background. We evaluated the influence of folate pathway polymorphisms on high-dose methotrexate (HD-MTX) related toxicity in paediatric patients with T-cell non-Hodgkin lymphoma (NHL). Patients and methods. In total, 30 NHL patients were genotyped for selected folate pathway polymorphisms. Results. Carriers of at least one MTHFR 677T allele had significantly higher MTX area under the time-concentration curve levels at third MTX cycle (P = 0.003). These patients were also at higher odds of leucopoenia (P = 0.006) or thrombocytopenia (P = 0.041) and had higher number of different HD-MTX-related toxicity (P = 0.035) compared to patients with wild-type genotype. Conclusions. Our results suggest an important role of MTHFR 677C>T polymorphism in the development of HD-MTXrelated toxicity in children with NHL.
Keywords: childhood, non-Hodgkin lymphoma, polymorphism
Published in DiRROS: 16.04.2024; Views: 14; Downloads: 4
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2. MRI-assisted cervix cancer brachytherapy pre-planning, based on application in paracervical anaesthesia : final reportPrimož Petrič, Robert Hudej, Omar Hanuna, Primož Marolt, Barbara Šegedin, 2014, original scientific article Abstract: Background. Optimal applicator insertion is a precondition for the success of cervix cancer brachytherapy (BT). We aimed to assess feasibility and efficacy of MRI-assisted pre-planning, based on applicator insertion in para-cervical anaesthesia (PCA). Patients and methods. Five days prior to BT, the pre-planning procedure was performed in 18 cervix cancer patients: tandem-ring applicator was inserted under PCA, pelvic MRI obtained and applicator removed. Procedure tolerability was assessed. High risk clinical target volume (HR CTV) and organs at risk were delineated on the pre-planning MRI, virtual needles placed at optimal positions, and dose planning performed. At BT, insertion was carried out in subarachnoidal anaesthesia according to pre-planned geometry. Pre-planned and actual treatment parameters were compared. Results. Pre-planning procedure was well tolerated. Median difference between the pre-planned and actual needle insertion depth and position were 2 (0%10) mm and 4 (0%30) degrees, respectively. The differences between the pre-planned and actual geometric and dosimetric parameters were statistically non-significant. All actual needles were positioned inside the HR CTV and outside the organs at risk (OAR). Conclusions. Our pre-planning approach is well tolerated and effective. Pre-planned geometry and dose distribution can be reproduced at BT.
Keywords: cervix cancer, pre-planning, image-guided brachytherapy
Published in DiRROS: 11.04.2024; Views: 79; Downloads: 28
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3. Clonality analysis of lymphoid proliferations using the BIOMED-2 clonality assays : a single institution experienceIra Koković, Barbara Jezeršek Novaković, Petra Škerl, Srdjan Novaković, 2014, original scientific article Abstract: Background. Clonality determination in patients with lymphoproliferative disorders can improve the final diagnosis.The aim of our study was to evaluate the applicative value of standardized BIOMED-2 gene clonality assay protocolsfor the analysis of clonality of lymphocytes in a group of different lymphoid proliferations.Materials and methods. With this purpose, 121 specimens from 91 patients with suspected lymphoproliferationssubmitted for routine diagnostics from January to December 2011 were retrospectively analyzed. According to thefinal diagnosis, our series comprised 32 cases of B-cell lymphomas, 38 cases of non-Hodgkins T-cell lymphomas and51 cases of reactive lymphoid proliferations. Clonality testing was performed using the BIOMED-2 clonality assays.Results. The determined sensitivity of the TCR assay was 91.9%, while the sensitivity of the IGH assay was 74.2%. Thedetermined specificity of the IGH assay was 73.3% in the group of lymphomas and 87.2% in the group of reactivelesions. The determined specificity of the TCR assay was 62.5% in the group of lymphomas and 54.3% in the group ofreactive lesions.Conclusions. In the present study, we confirmed the utility of standardized BIOMED-2 clonality assays for the detectionof clonality in a routine diagnostical setting of non-Hodgkins lymphomas. Reactions for the detection of thecomplete IGH rearrangements and reactions for the detection of the TCR rearrangements are a good choice forclonality testing of a wide range of lymphoid proliferations and specimen types while the reactions for the detectionof incomplete IGH rearrangements have not shown any additional diagnostic value.
Keywords: Biomed-2, clonality analysis, lymphomas, IGH rearrangement, TCR rearrangement
Published in DiRROS: 11.04.2024; Views: 45; Downloads: 12
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4. Clonality analysis of lymphoid proliferations using BIOMED-2 clonality assays : a single institution experienceIra Kokovič, Barbara Jezeršek Novaković, Petra Škerl, Srdjan Novaković, 2014, professional article Keywords: onkologija, rak (medicina), limfom, diagnostika, analiza, molekularne metode, molekularna diagnostika
Published in DiRROS: 10.04.2024; Views: 64; Downloads: 14
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5. What about the family? : The well-being of migrant children in comparative perspectiveZorana Medarić, Barbara Gornik, 2024, original scientific article Abstract: This article explores the subjective perceptions of well-being of migrant children attending primary school (9-14 years) and secondary school (15-18 years) in Slovenia. It focuses on how they conceptualise their fears, worries and concerns, what is important for them to feel accepted and safe, and how they think about their past and the future. Using a comparative perspective, similarities and differences in the experience of well-being of these two age groups of migrants are explored. The analysis is based on open-ended narrative interviews with migrant children and revolves around the question of whether and how age influences their subjective perception of well-being. The article sheds light on age-specific meanings and understandings of migration processes based on the views and experiences of migrant children and youth regarding their well-being, bringing to the fore the perspectives of children that are often missing or underrepresented in integration policy.
Keywords: acceptance, agency, well-being, age differences, migrant children
Published in DiRROS: 09.04.2024; Views: 75; Downloads: 26
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8. Poročilo o preskusu št.: LVG 2024-017 : vzorec št. 2023/00753Tine Hauptman, Zina Devetak, Špela Hočevar, Barbara Piškur, 2024, expertise, arbitration decision Keywords: varstvo gozdov, morfološke analize, Fagus sylvatica, bukev, Botryosphaeria dothidea
Published in DiRROS: 04.04.2024; Views: 58; Downloads: 17
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9. Poročilo o preskusu št.: LVG 2024-016 : vzorec št. 2024/00046Tine Hauptman, Zina Devetak, Špela Hočevar, Barbara Piškur, 2024, expertise, arbitration decision Keywords: varstvo gozdov, morfološke analize, Cerambycidae, kozlički, Scolytinae, podlubniki
Published in DiRROS: 04.04.2024; Views: 49; Downloads: 0 |
10. Poročilo o preskusu št.: LVG 2024-013 : vzorec št. 2024/00001/G1Tine Hauptman, Nikica Ogris, Zina Devetak, Špela Hočevar, Barbara Piškur, 2024, expertise, arbitration decision Keywords: varstvo gozdov, morfološke analize, Cryphonectria carpinicola, rak belega gabra
Published in DiRROS: 04.04.2024; Views: 41; Downloads: 19
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