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Uterine perforation - 5-year experience in 3-D image guided gynaecological brachytherapy at Institute of Oncology Ljubljana
Barbara Šegedin, Jasenka Gugić Kevo, Primož Petrič, 2013, izvirni znanstveni članek

Povzetek: Background. Accurate applicator placement is a precondition for the success of gynaecological brachytherapy (BT). Unrecognized uterine perforation can lead to bleeding, infection, high doses to pelvic organs and underdosage of the target volume, resulting in acute morbidity, long-term complications and reduced chance of cure. We aimed to assess the incidence and clinical characteristics of our cases with uterine perforation, review their management and impact on the treatment course. Patinets and methods. In all patients, treated with utero-vaginal image guided BT for gynaecological cancer between January 2006 and December 2011, the CT/MR images with the applicator in place were reviewed. The incidence of uterine perforations was recorded. Clinical factors that may have predisposed to increased risk of perforation were recorded. Management of perforations and their impact on treatment course was assessed. Results. 219 patients (428 applications) were suitable for analysis. Uterine perforation was found in 13 (3.0%) applications in 10 (4.6%) patients. The most frequent perforation site was posterior uterine wall (n = 9), followed by anterior wall (n = 2) and fundus (n = 2). All cases were managed conservatively, without complications. Prophylactic antibiotics were administered in 8 cases. In 4 patients, abdominal and/or transrectal ultrasound (US) guidance was used on subsequent applications for applicator insertion; adequate applicator placement was achieved and treatment completed as planned in all cases. Conclusions. 3D imaging for BT planning enables accurate identification of uterine perforations. The incidence of perforations at our department is one of the lowest reported in the literature. US guidance of applicator insertion is useful and feasible, allowing to complete the planned treatment even in challenging cases.
Ključne besede: uterine perforation, brachytherapy, 3D imaging, ultrasound guidance
Objavljeno v DiRROS: 22.03.2024; Ogledov: 39; Prenosov: 16
.pdf Celotno besedilo (367,57 KB)

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Long term outcome after combined modality treatment for anal cancer
Irena Oblak, Primož Petrič, Franc Anderluh, Vaneja Velenik, Albert-Peter Fras, 2012, izvirni znanstveni članek

Povzetek: Background. The aim of the retrospective study was to evaluate the effectiveness and toxicity of radiochemotherapy in patients with squamous cellcarcinoma of the anal canal treated at a single institution. Patients and methods. Between 1/2003 and 9/2010, 84 patients were treated with radical radiochemotherapy at the Institute of Oncology Ljubljana, Slovenia. The treatment consisted of 3-dimensional conformal external beam radiotherapy with concurrent chemotherapy (5-fluorouracil and mytomycin C), followed by brachytherapy or external beam boost. The toxicity of therapy and its effectiveness were assessed. Results. The treatment was completed according tothe protocol in 79.8% of patients. The median follow-up time of 55 survivors was 53 months (range: 16-105 months). The 5-year locoregional control(LRC), disease-free survival (DFS), disease-specific survival (DSS), overall survival (OS) and colostomy-free survival (CFS) rates were 71%, 68%, 81%, 67% and 85%, respectively. No treatment-related mortality was observed. The most frequent acute side-effect of the treatment was radiodermatitis (grade 3-4 in 58.2% of patients). LENT-SOMA grade 3-4 late radiation side effects were observed in 15 (18%) patients. In patients with brachytherapy boost a trend of less late side effects was observed compared to patients with external beam boost (P=0.066). On multivariate analysis, complete clinicaldisease response was identified as an independent prognostic factor for LRC, DFS and DSS, the salvage surgery for LRC and DFS, whereas Hb below 120 g/l retained its independent prognostic value for OS. Conclusions. Radiochemotherapy provides an excellent disease control and the survival with preserving anal sphincter function in majority of patients. Surgical salvage with abdominoperineal resection for persistent or recurrent disease has curative potential.
Objavljeno v DiRROS: 21.03.2024; Ogledov: 55; Prenosov: 22
.pdf Celotno besedilo (533,54 KB)

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Obsevanje ginekoloških tumorjev
Primož Petrič, Barbara Šegedin, Helena Barbara Zobec Logar, Vesna Robič, Albert-Peter Fras, Borut Kragelj, 2011, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid

Ključne besede: teleterapija, brahiterapija, prehrana, kemoterapija, stranski učinki
Objavljeno v DiRROS: 28.05.2020; Ogledov: 1760; Prenosov: 521
.pdf Celotno besedilo (8,10 MB)

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Paliativna oskrba bolnikov z rakom : zbornik
2005, zbornik strokovnih ali nerecenziranih znanstvenih prispevkov na konferenci

Ključne besede: zborniki
Objavljeno v DiRROS: 17.09.2019; Ogledov: 1944; Prenosov: 579
.pdf Celotno besedilo (12,35 MB)

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Novosti v onkologiji in smernice za obravnavo bolnic z rakom dojk in bolnikov z malignim melanomom : zbornik
2004, zbornik strokovnih ali nerecenziranih znanstvenih prispevkov na konferenci

Ključne besede: zborniki
Objavljeno v DiRROS: 17.09.2019; Ogledov: 2257; Prenosov: 667
.pdf Celotno besedilo (10,71 MB)

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Obsevanje ginekoloških tumorjev : navodila za bolnice
Primož Petrič, Barbara Šegedin, Helena Barbara Zobec Logar, Vesna Robič, Albert-Peter Fras, Borut Kragelj, 2011, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid

Povzetek: Pričujoča knjižica je namenjena bolnicam, ki se zdravijo zaradi ginekološkega raka z obsevanjem. Preko kratke razlage pojmov vas na poljuden način vodi skozi pripravo na obsevanje, prehrano med obsevanjem, seznani vas z možnostjo sočasne kemoterapije in ukrepi za preprečevanje njenih stranskih učinkov. Prav tako so razloženi stranski učinki obsevanja, v zaključku pa dobite še nekaj informacij, ki vas morda zanimajo ob koncu zdravljenja.
Ključne besede: teleterapija, brahiterapija, prehrana, kemoterapija, stranski učinki
Objavljeno v DiRROS: 25.03.2019; Ogledov: 2992; Prenosov: 790
.pdf Celotno besedilo (8,10 MB)

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