21. Reviewing the modeling aspects and practices of shallow geothermal energy systemsPaul Christodoulides, Ana Vieira, Stanislav Lenart, João Maranha, Gregor Vidmar, Rumen Popov, Aleksandar Georgiev, Lazaros Aresti, Georgios Florides, 2020, pregledni znanstveni članek Povzetek: Shallow geothermal energy systems (SGES) may take different forms and have recently taken considerable attention due to energy geo-structures (EGS) resulting from the integration of heat exchange elements in geotechnical structures. Still, there is a lack of systematic design guidelines of SGES. Hence, in order to contribute towards that direction, the current study aims at reviewing the available SGES modeling options along with their various aspects and practices. This is done by first presenting the main analytical and numerical models and methods related to the thermal behavior of SGES. Then, the most important supplementary factors affecting such modeling are discussed. These include: (i) the boundary conditions, in the form of temperature variation or heat flow, that majorly affect the predicted thermal behavior of SGES; (ii) the spatial dimensions that may be crucial when relaxing the infinite length assumption for short heat exchangers such as energy piles (EP); (iii) the determination of SGES parameters that may need employing specific techniques to overcome practical difficulties; (iv) a short-term vs. long-term analysis depending on the thermal storage characteristics of GHE of different sizes; (v) the influence of groundwater that can have a moderating effect on fluid temperatures in both heating and cooling modes. Subsequently, thermo-mechanical interactions modeling issues are addressed that may be crucial in EGS that exhibit a dual functioning of heat exchangers and structural elements. Finally, a quite lengthy overview of the main software tools related to thermal and thermo-hydro-mechanical analysis of SGES that may be useful for practical applications is given. A unified software package incorporating all related features of all SGES may be a future aim.
Ključne besede: shalow geothermal energy systems, energy geo-structures, thermal analysis, thermo-hydro-mechanical, modelling, software tools
Objavljeno v DiRROS: 05.03.2024; Ogledov: 118; Prenosov: 53
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22. Metal–support interaction between titanium oxynitride and Pt nanoparticles enables efficient low-Pt-loaded high-performance electrodes at relevant oxygen reduction reaction current densitiesArmin Hrnjić, Ana Rebeka Kamšek, Lazar Bijelić, Anja Logar, Nik Maselj, Milutin Smiljanić, Jan Trputec, Natan Vovk, Luka Pavko, Francisco Ruiz-Zepeda, Marjan Bele, Primož Jovanovič, Nejc Hodnik, 2024, izvirni znanstveni članek Objavljeno v DiRROS: 04.03.2024; Ogledov: 112; Prenosov: 50
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24. Incidenca raka v prvem letu epidemije covida-19Vesna Zadnik, Tina Žagar, Nika Bric, Mojca Birk, Amela Duratović Konjević, Ana Mihor, Katarina Lokar, Sonja Tomšič, 2023, strokovni članek Povzetek: Uvod: Število novih diagnoz raka (incidenca) se v Sloveniji v zadnjem desetletju povečuje za povprečno 1,6 % na leto. V letu 2020, prvem letu omejitvenih ukrepov zaradi epidemije covida19, smo s platformo OnKOvid predvideli 3–8-odstotni padec novih diagnoz raka. Namen je predstaviti uradno incidenco raka za Slovenijo za leto 2020 in ugotoviti, kolikšen je bil dejansko manko novih diagnoz raka. Metode: V Registru raka Republike Slovenije smo v skladu z mednarodnimi pravili registrirali vse nove primere raka pri prebivalcih s stalnim prebivališčem v Sloveniji. Primerjali smo jih z registrirano incidenco za 2019, modelno incidenco za 2020, preliminarnimi rezultati OnKovida in dostopnimi rezultati incidence iz registrov raka iz drugih držav. Rezultati: V letu 2020 je za rakom zbolelo 15.096 oseb v Sloveniji (7.034 žensk, 8.002 moška). Glede na modelno oceno incidence za leto 2020 gre za manko 1.854 oseb (10,9 %; 11,6 % žensk, 10,4 % moških). Pri tem je za 10,5 % manj ugotovljenih rakov v omejenem stadiju, najbolj izrazito v starosti 50–69 let (za 13,2 %). Upad je primerljiv s poročili iz Anglije, ZDA in Kanade ter deloma večji kot na Škotskem in Švedskem. Najbolj izrazit upad novih diagnoz raka ugotavljamo pri nemelanomskem kožnem raku (23 %, najbolj po 50. letu), raku prostate (15,9 %, najbolj v omejenem stadiju), pljučnem raku (8,9 %, 60–64 let, v razširjenem stadiju), raku dojk (8,3 %, 45–64 let), ne-Hodgkinovem limfomu (9 %) in levkemijah (11,6 %). Pri kožnem melanomu, raku debelega črevesa in danke ni bilo primanjkljaja. Zaključek: Upad incidence raka v letu 2020 gre verjetno na račun omejitvenih ukrepov, reorganizacije zdravstva in z zdravjem povezanega vedenja med epidemijo covida-19, beležijo jo v več državah. Med epidemijami je potrebno nemoteno izvajanje onkologije.
Ključne besede: rak, incidenca, register raka, epidemija, covid-19
Objavljeno v DiRROS: 26.02.2024; Ogledov: 138; Prenosov: 31
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26. The role of p38 MAP kinase in cancer cell apoptosisMetka Lenassi, Ana Plemenitaš, 2006, pregledni znanstveni članek Povzetek: Background. Cellular behaviour in response to many extracellular stimuli is mediated through MAP kinase signalling pathways. p38 MAP kinase that is represented in mammals by four isoforms (p38alfa, p38beta, p38gama and p38delta) is one of the four main subgroups of MAP kinases. Recent studies show that p38 activation is necessary for cancer cell death initiated by variety of anti-cancer agents. This finding connected cancer therapies previously considered to be mechanistically unrelated and raised the possibility of developing anti-cancer agents that lack the side effects causedby events upstream of p38 MAPK Many of the details of p38 induced apoptosis still need to be elucidated. Since most of the past studies rely only on the cell culture models, all the results have to be verified using in vivo models. Also very little is known about the role of p38 mediated apoptosis on non-neoplastic cells in response to anti-cancer agents. Conclusion. Although p38 activation of cancer cell apoptosis is a very complexprocess, recent studies indicate a good starting point for new strategies that would increase the efficiency and decrease the toxicity of proven therapies.
Objavljeno v DiRROS: 15.02.2024; Ogledov: 136; Prenosov: 26
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27. Schedule-dependency of doxorubicin and vinblastine in EAT tumours in miceMarija Auersperg, Ana Pogačnik, Veronika Kloboves-Prevodnik, Gregor Serša, Maja Čemažar, 2006, izvirni znanstveni članek Povzetek: Background. Antitumour schedule-dependency of the doxorubicin and vinblastine combination was explored. Materials and methods. Intraperitoneal Ehrlich ascites tumours (EAT) syngeneic to CBA mice were treated with vinblastine ar doxorubicin alone, or in combined treatment schedules. Results. Combinations of doxorubicin and vinblasfine administered at 48-h, but not at 24-h interval,regardless of the sequence of drugs, significantly reduced the numberof tumour cells in the ascites in corrtparison with all other treatments. In the combined treatment schedules, the predominant morphologicalchanges as well as DNA distribution pattern were dependent on thefirst drug applied. Regardless of the sequence of the drugs, median survival times of animals did not significantly differ between the treatment groups. Conclusions. The effect of combination of vinblastine and doxorubicin is schedule-dependent. The time interval, but not the sequence of drugs seems to be crucial for the observed effect. The data from preclinical studies are important for planning combined treatment schedules in clinical setting.
Objavljeno v DiRROS: 15.02.2024; Ogledov: 103; Prenosov: 23
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28. An outbreak of Verticillium dahliae on sycamore maple in a forest stand in SloveniaAna Brglez, Zina Devetak, Nikica Ogris, Sebastjan Radišek, Barbara Piškur, 2024, izvirni znanstveni članek Povzetek: Verticillium dahliae Kleb., the causal agent of Verticillium wilts, is a devastating plant disease affecting many plant species. Fungus V. dahliae was detected in a partially artificially established Acer pseudoplatanus L. forest stand in central Slovenia. This finding incited further study about the risk of different sources of V. dahliae isolates for maples in forests and the pathogenicity of three V. dahliae isolates of different origins was tested on saplings of A. pseudoplatanus, A. platanoides L., and A. campestre L. The inoculated saplings exhibited disease symptoms, i.e., leaf necrosis and wilting. At the end of the pathogenicity test, typical xylem browning was visible on the cross-sections, and the pathogen was successfully re-isolated. The isolates showed significant differences in their pathogenicity to specific maple hosts, with the agricultural isolate (originated from bell pepper) being the most aggressive on all three maple species. The disease severity index (DSI) and relative area under the disease progress curve (rAUDPC), as well as the success of re-isolation, indicate that A. platanoides is the most susceptible to inoculation with V. dahliae. In addition, significant differences in sapling biomass were observed between treated and control plants. These results suggest that maples in forest stands are threatened by V. dahliae, and biosecurity measures should be considered and implemented in forest management to reduce the transmission and potential spread of the pathogen.
Ključne besede: Verticillium wilt, Acer spp., pathogenicity test, Disease severity index, DSI, Area under the disease progress curve, AUDPC, biosecurity
Objavljeno v DiRROS: 07.02.2024; Ogledov: 180; Prenosov: 80
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30. Patogenost izolatov izbranih vrst gliv na Pinus sylvestris L. IN P. nigra ArnoldAna Brglez, Barbara Piškur, Nikica Ogris, 2023, izvirni znanstveni članek Povzetek: Na sadikah rdečega in črnega bora smo testirali patogenost osmih izbranih izolatov gliv (Corinectria fuckeliana, Diaporthe eres, Diplodia pinea, Fusarium sp. 1 in 2, Fusicolla sp., Nectria dematiosa in Tympanis sp.), ki smo jih izolirali iz obolelih borovih dreves v Sloveniji v letih 2020 in 2021. Inokulirali smo skupno 115 sadik borov (vključno s kontrolo), periodično smo preverjali njihovo zdravstveno stanje in ob prvih znakih sušenja opravili reizolacije iz robov nastalih nekroz. Reizolacije so bile uspešne le v primeru inokulacije z vrstami gliv Diplodia pinea, Diaporthe eres in Fusarium sp. 2. Povprečna dolžina nekroz sadik rdečega bora, inokuliranih z D. pinea, Di. eres in Tympanis sp., se je statistično značilno razlikovala od kontrolnih sadik (p < 0,05). Pri sadikah črnega bora pa so se za statistično značilne izkazale povprečne dolžine nekroz pri kontroli in inokulacijah z glivama D. pinea in Tympanis sp. (p < 0,05).
Ključne besede: test patogenosti, reizolacije, Pinus sylvestris, rdeči bor, Pinus nigra, črni bor
Objavljeno v DiRROS: 25.01.2024; Ogledov: 413; Prenosov: 159
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