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Query: "author" (Markelc Boštjan) .

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1.
Effects of electrochemotherapy on immunologically important modifications in tumor cells
Urša Kešar, Boštjan Markelc, Tanja Jesenko, Katja Uršič Valentinuzzi, Maja Čemažar, Primož Strojan, Gregor Serša, 2023, original scientific article

Abstract: Electrochemotherapy (ECT) is a clinically acknowledged method that combines the use of anticancer drugs and electrical pulses. Electrochemotherapy with bleomycin (BLM) can induce immunogenic cell death (ICD) in certain settings. However, whether this is ubiquitous over different cancer types and for other clinically relevant chemotherapeutics used with electrochemotherapy is unknown. Here, we evaluated in vitro in the B16-F10, 4T1 and CT26 murine tumor cell lines, the electrochemotherapy triggered changes in the ICD-associated damage-associated molecular patterns (DAMPs): Calreticulin (CRT), ATP, High Mobility Group Box 1 (HMGB1), and four immunologically important cellular markers: MHCI, MHC II, PD-L1 and CD40. The changes in these markers were investigated in time up to 48 h after ECT. We showed that electrochemotherapy with all three tested chemotherapeutics induced ICD-associated DAMPs, but the induced DAMP signature was cell line and chemotherapeutic concentration specific. Similarly, electrochemotherapy with CDDP, OXA or BLM modified the expression of MHC I, MHC II, PD-L1 and CD40. The potential of electrochemotherapy to change their expression was also cell line and chemotherapeutic concentration specific. Our results thus put the electrochemotherapy with clinically relevant chemotherapeutics CDDP, OXA and BLM on the map of ICD inducing therapies.
Keywords: electrochemotherapy, cisplatin, immune response
Published in DiRROS: 21.03.2024; Views: 49; Downloads: 26
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Molekularne in transkripcijske spremembe tumorskih endotelijskih celic po obsevanju pri miših
Iva Šantek, Tim Božič, Gregor Serša, Boštjan Markelc, 2023, published scientific conference contribution abstract

Keywords: miši, obsevanje, gensko zdravljenje
Published in DiRROS: 19.06.2023; Views: 330; Downloads: 132
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Razvoj in karakterizacija mišjega modela za študije HPV-pozitivnega raka glave in vratu
Živa Modic, Maja Čemažar, Boštjan Markelc, Andrej Cör, Gregor Serša, Simona Kranjc Brezar, Tanja Jesenko, 2023, published scientific conference contribution abstract

Keywords: miši, rak glave in vratu, gensko zdravljenje
Published in DiRROS: 19.06.2023; Views: 338; Downloads: 146
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Smrt endotelijskih celic po ionizirajočem sevanju ne vpliva na funkcionalnost tumorskega žilja v mišjih tumorskih modelih
Boštjan Markelc, 2023, published scientific conference contribution abstract

Keywords: miši, obsevanje, gensko zdravljenje
Published in DiRROS: 19.06.2023; Views: 279; Downloads: 127
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Sproščanje dejavnikov imunogene celične smrti HMGB1 in ATP iz celičnih linij se povečuje s časom po obsevanju
Urša Kešar, Tanja Jesenko, Boštjan Markelc, Katja Uršič Valentinuzzi, Maja Čemažar, Primož Strojan, Gregor Serša, 2023, published scientific conference contribution abstract

Keywords: miši, obsevanje, radioterapija
Published in DiRROS: 19.06.2023; Views: 296; Downloads: 138
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Obsevanje in genska terapija s kemokinoma CCL5 ali CCL17 na mišjih modelih karcinoma
Tim Božič, Simona Kranjc Brezar, Boštjan Markelc, Maja Čemažar, 2023, published scientific conference contribution abstract

Keywords: miši, obsevanje, gensko zdravljenje
Published in DiRROS: 19.06.2023; Views: 307; Downloads: 135
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