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Iskalni niz: "avtor" (Mali Gregor) .

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Study of water adsorption on EDTA-modified LTA zeolites
Janez Volavšek, O. L. Pliekhov, Olena Pliekhova, Gregor Mali, Nataša Zabukovec Logar, 2022, izvirni znanstveni članek

Ključne besede: 4A zeolite, 5A zeolite, LTA topology, water adsorption, EDTA dealumination, 27Al NMR, 29Si NMR
Objavljeno v DiRROS: 09.05.2022; Ogledov: 321; Prenosov: 199
.pdf Celotno besedilo (2,69 MB)
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Quinone-formaldehyde polymer as an active material in Li-ion batteries
Klemen Pirnat, Gregor Mali, Miran Gaberšček, Robert Dominko, 2016, izvirni znanstveni članek

Objavljeno v DiRROS: 06.04.2016; Ogledov: 4851; Prenosov: 687
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Comparative study of interactions of aliskiren and AT [sub] 1 receptor antagonists with lipid bilayers
A. Sadegphour, Michael Rappolt, Dimitrios Ntountaniotis, Petros Chatzigeorgioug, Kyriakos Viras, Grigorios Megariotis, M. Papadopoulos, Eleni Siapi, Gregor Mali, Thomas Michael Mavromoustakos, 2015, izvirni znanstveni članek

Povzetek: The renin-angiotensin-aldosterone system (RAAS) plays a key role in the regulation of blood pressure. Renin is the rate limiting enzyme of the RAAS and aliskiren is a highly potent and selective inhibitor of the human renin. Renin is known to be active both in the circulating blood stream as well as locally, when bound to the (pro)-renin receptor ((P)RR). In this study we have investigated a possible mechanism of action of aliskiren, in which its accumulation in the plasma membrane is considered as an essential step for effective inhibition. Aliskiren's interactions with model membranes (cholesterol rich and poor) have been investigated by applying different complementary techniques: differential scanning calorimetry (DSC), Raman spectroscopy, magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and small- and wide-angle X-ray scattering (SAXS and WAXS). In addition, in silico molecular dynamics (MD) calculations were applied for further confirmation of the experimental data. Aliskiren's thermal effects on the pre- and main transition of dipalmitoyl-phosphatidylcholine (DPPC) membranes as well as its topographical position in the bilayer show striking similarities to those of II type 1 receptor (AT1R) antagonists. Moreover, at higher cholesterol concentrations aliskiren gets expelled from the membrane just as it has been recently demonstrated for the angiotensin receptor blocker (ARB) losartan. Thus, we propose that both the AT1R and the (P)RR-bound renin active sites can be efficiently blocked by membrane-bound ARBs and aliskiren when cholesterol rich membrane rafts/caveolae are formed in the vicinity of the receptors.
Ključne besede: aliskiren, renin, PRR, DPPC bilayers, raman spectroscopy, solid state NMR spectroscopy, SAXS and WAXS, MD simulations
Objavljeno v DiRROS: 26.01.2015; Ogledov: 3952; Prenosov: 205
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