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Emerging organic compounds in European groundwater
B. Lopez, A. Togola, M. E. van Vliet, L. Rosenqvist, Nina Mali, A. Kuczyńska, Anja Koroša, J. Grima-Olmedo, E. J. Crane, D. J. Lapworth, S. Y. Bunting

Povzetek: In Europe, emerging organic compounds (EOCs) in groundwater is a growing research area. Prioritisationfor monitoring EOCs in Europe was formalised in 2019 through the development of thefirst voluntarygroundwater watch list (GWWL). Despite this, groundwater occurrence data in the peer reviewedliterature for Europe has not been reviewed to date. Questions surrounding the effect, toxicity, move-ment in the subsurface and unsaturated zone make the process of regulating EOC use difficult. The aim inEurope is to develop a unified strategy for the classification, and prioritisation of EOCs to be monitored ingroundwater. This paper compiles evidence from the recent published studies from across Europe, since2012, when the last major literature global review of EOCs in groundwater took place. A total of 39studies were identified for review based on specific selection criteria (geography, publication date,sample size>10, inclusion of EOCs data). Data on specific compounds, and associated meta-data, arecompiled and reviewed. The two most frequently detected EOCs, carbamazepine and caffeine, occurredin groundwater at concentrations of up to 2.3 and 14.8mg/L, respectively.
Ključne besede: emerging organic chemicals, environmental exposure, groundwater contaminants, compounds of concern, groundwater hazards
DiRROS - Objavljeno: 13.01.2021; Ogledov: 593; Prenosov: 263
.pdf Celotno besedilo (1,90 MB)

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Comparative study of interactions of aliskiren and AT [sub] 1 receptor antagonists with lipid bilayers
Gregor Mali, Eleni Siapi, M. Papadopoulos, Grigorios Megariotis, Kyriakos Viras, Petros Chatzigeorgioug, Dimitrios Ntountaniotis, Michael Rappolt, A. Sadegphour, Thomas Michael Mavromoustakos, 2015

Povzetek: The renin-angiotensin-aldosterone system (RAAS) plays a key role in the regulation of blood pressure. Renin is the rate limiting enzyme of the RAAS and aliskiren is a highly potent and selective inhibitor of the human renin. Renin is known to be active both in the circulating blood stream as well as locally, when bound to the (pro)-renin receptor ((P)RR). In this study we have investigated a possible mechanism of action of aliskiren, in which its accumulation in the plasma membrane is considered as an essential step for effective inhibition. Aliskiren's interactions with model membranes (cholesterol rich and poor) have been investigated by applying different complementary techniques: differential scanning calorimetry (DSC), Raman spectroscopy, magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and small- and wide-angle X-ray scattering (SAXS and WAXS). In addition, in silico molecular dynamics (MD) calculations were applied for further confirmation of the experimental data. Aliskiren's thermal effects on the pre- and main transition of dipalmitoyl-phosphatidylcholine (DPPC) membranes as well as its topographical position in the bilayer show striking similarities to those of angiotens.in II type 1 receptor (AT1R) antagonists. Moreover, at higher cholesterol concentrations aliskiren gets expelled from the membrane just as it has been recently demonstrated for the angiotensin receptor blocker (ARB) losartan. Thus, we propose that both the AT1R and the (P)RR-bound renin active sites can be efficiently blocked by membrane-bound ARBs and aliskiren when cholesterol rich membrane rafts/caveolae are formed in the vicinity of the receptors.
Ključne besede: aliskiren, renin, PRR, DPPC bilayers, raman spectroscopy, solid state NMR spectroscopy, SAXS and WAXS, MD simulations
DiRROS - Objavljeno: 26.01.2015; Ogledov: 3502; Prenosov: 137

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Spremembe izbranih demografskih in krajinskih kazalnikov v kraških krajinah notranje Slovenije v zadnjih štirih desetletjih
Andreja Ferreira, Boštjan Mali, Andrej Kobler, 2018

Povzetek: Na primeru krajinske regije Kraške krajine notranje Slovenije smo analizirali osnovne demografske kazalnike (število prebivalcev, gostota poselitve) in izbrane krajinske kazalnike (gozdnatost, število gozdnih zaplat, površina največje gozdne zaplate, delež jedrnih območij v gozdu), njihove spremembe v zadnjih štirih desetletjih in njihove medsebojne korelacije. Te smo preverjali s Pearsonovim korelacijskim koeficientom. Ugotovili smo več statistično značilnih povezav med demografskimi in krajinskimi kazalniki. Na območjih z večjo gostoto poselitve je značilen nižji delež gozda, in sicer v obeh preučevanih letih. Večji delež gozda po pričakovanjih pomeni večji delež jedrnih območij v gozdu ter večjo površino največje gozdne zaplate.
Ključne besede: demografski kazalniki, krajinski kazalniki, gozdovi, krajina, Kraške krajine notranje Slovenije, Slovenija, Kras
DiRROS - Objavljeno: 13.11.2018; Ogledov: 3226; Prenosov: 1523
.pdf Celotno besedilo (9,77 MB)

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Information on LULUCF actions Slovenia
Tomaž Vernik, Boštjan Mali, 2015

Ključne besede: raba prostora, toplogredni plini, gozdarstvo, kmetijstvo, emisije
DiRROS - Objavljeno: 03.11.2021; Ogledov: 35; Prenosov: 17
.pdf Celotno besedilo (11,64 MB)

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Kvaliteta lesa v semenskem sestoju na Blegošu : seminarsko delo
Boštjan Mali, 2007

Ključne besede: semenski sestoji, kvaliteta lesa, les, Blegoš
DiRROS - Objavljeno: 12.07.2017; Ogledov: 1949; Prenosov: 572
.pdf Celotno besedilo (8,03 MB)

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