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Povzetek: Introduction: Rearranged during transfection (RET) gene fusions are rare genetic drivers in non-small cell lung cancer (NSCLC). Selective RET-inhibitors such as selpercatinib have shown therapeutic activity in early clinical trials; however, their efficacy in the real-world setting is unknown. Methods: A retrospective efficacy and safety analysis was performed on data from RET fusio-%positive NSCLC patients who participated in a selpercatinib access program (named patient protocol) between August 2019 and January 2021. Results: Data from 50 patients with RET fusion-positive advanced NSCLC treated with selpercatinib at 27 centers in 12 countries was analyzed. Most patients were Non-Asian (90%), female (60%), never-smokers (74%), with a median age of 65 years (range, 38-89). 32% of the patients had known brain metastasis at the time of selpercatinib treatment. Overall, 13 patients were treatment-naïve, while 37 were pretreated with a median of three lines of therapy (range, 1-8). The objective response rate (ORR) was 68% [95% confidence interval (CI), 53-81] in the overall population. The disease control rate was 92%. The median progression-free survival was 15.6 months (95% CI, 8.8-22.4) after a median follow-up of 9 months. In patients with measurable brain metastases (n=8) intracranial ORR reached 100%. In total, 88% of patients experienced treatment-related adverse events (TRAEs), a large majority of them being grade 1 or 2. The most common grade >/=3 TRAEs were increased liver enzyme levels (in 10% of patients), prolonged QTc time (4%), abdominal pain (4%), hypertension (4%), and fatigue/asthenia (4%). None of patients discontinued selpercatinib treatment for safety reasons. No new safety concerns were observed, nor where there any treatment-related death. Conclusions: In this real-world setting, the selective RET-inhibitor selpercatinib demonstrated durable systemic and intracranial antitumor activity in RET fusion-positive NSCLC and was well tolerated.
Ključne besede: non-small cell lung carcinoma -- drug therapy -- genetics, molecular targeted therapy, real-world data, selpercatinib, targeted therapy, tyrosine kinase inhibitor
Objavljeno v DiRROS: 16.06.2021; Ogledov: 1280; Prenosov: 714
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Povzetek: Background. Identification of infected healthcare workers (HCWs) is an important step in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) transmission control. Rapid antigen tests (RATs) are considered an important addition to molecular tests in diagnosing coronavirus disease 2019 (COVID-19), mainly because of their fast turnaround time, easier analytical procedure and lower price. However, real-life studies on the usefulness of such testing for screening of HCWs are limited. Methods. Physicians, nurses and hospital attendants currently working at the University Clinic of Respiratory and Allergic Diseases Golnik were invited to participate in the pilot study. Nasopharyngeal swabs were obtained three times per week for two consecutive weeks and tested with a point-of-care RAT and reverse transcription polymerase chain reaction (RT-PCR). Serum samples were obtained at the beginning of the study and 2 weeks after the last swab was collected to evaluate the serological status. Results. A total of 191 nasopharyngeal swabs from 36 HCWs were obtained. None of the samples tested was positive for the presence of SARS-CoV-2 antigen, whereas two HCWs tested positive on RT-PCR. Of these, one HCW had a newly identified SARS-CoV-2 infection, whereas RT-PCR probably detected a previous but recent infection in the other HCW. Conclusio.n Based on the results of this pilot study, it is unlikely that RAT will reliably detect novel SARS-CoV-2 infections among asymptomatic HCWs despite serial sampling. Although RT-PCR-based screening of HCWs may not be feasible due to high sample volume, molecular methods may identify SARS-CoV-2-infected HCWs already during the presymptomatic stage.
Ključne besede: SARS-CoV-2, health personnel, COVID-19 serological testing, real-time polymerase chain reaction, rapid antigen test, screening
Objavljeno v DiRROS: 28.05.2021; Ogledov: 1046; Prenosov: 308
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Povzetek: V okviru javne službe za izvajanje strokovnih nalog v oljkarstvu, so bile v letu 2019 izvedene naloge: selekcija, introdukcija, razmnoževanje sadilnega material, ugotavljanje ustreznih tehnologije za pridelavo oljk ter ugotavljanje vrednosti oljk za predelavo. V poročilu so zbrane morfološke in agronomske lastnosti ter značilnosti oljčnega olja sort "Buga", "Črnica" in "Drobnica", "Maurino", "Arbequina", "Leccione", "Itrana", "Leccio del corno" in "Štorta" za opazovanja v letu 2019. Predstavljeni so tudi rezultati genotipizacije izbranih sort ter agronomskega vrednotenja in fenofaze različnih sort, ki so zasajene v introdukcijsko-kolekcijskem nasadu Purissima in Šempeter. V poročilu so zbrani tudi podatki tehnološkega poskusa preverjanja učinkovitosti fitofarmacevtskih sredstev pri zatiranju oljčnega molja ter parametri, ki karakterizirajo posamezna sortna olja ter parametri kakovosti oljčnega olja letnika 2019.
Ključne besede: elektronske knjige
Objavljeno v DiRROS: 13.05.2021; Ogledov: 1053; Prenosov: 496
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Povzetek: Sorta Arbequina je v Kataloniji poznana kot sorta, odporna na mraz. Zelo je cenjena zaradi visoke in redne rodnosti. V primerjavi z našimi glavnimi sortami je sicer nekoliko bolj občutljiva na nizke temperature, vendar je hkrati sorta, ki tudi v naših razmerah zelo zgodaj stopi v rodnost in daje redne in velike pridelke.
Ključne besede: oljka, sorte, molekularna genetika, rastlinska morfologija, elektronske knjige
Objavljeno v DiRROS: 13.05.2021; Ogledov: 1051; Prenosov: 543
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Povzetek: Sorta 'Leccio del Corno' ni občutljiva na nizke temperature. Drevo sorte 'Leccio del Corno' je srednje bujne rasti, krošnja pa je zbita zaradi kratkih internodijev. Za oploditev potrebuje opraševalne sorte, kot sta 'Pendolino' in 'Frantoio' (nekoliko manj 'Moraiolo'). Dozorevanje plodov je pozno. Sorta ima izmenično rodnost. Olje vsebuje srednje veliko tokoferolov in biofenolov ter velik delež oleinske kisline. Odporna je proti pavjemu očesu.
Ključne besede: oljka, sorte, molekularna genetika, rastlinska morfologija, elektronske knjige
Objavljeno v DiRROS: 13.05.2021; Ogledov: 1257; Prenosov: 588
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