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41.
Dinamika dolžine telomerov v levkocitih po zdravljenju z obsevanjem pri raku dojk
Tanja Marinko, Sara Redenšek Trampuž, Ana Trstenjak, Vita Dolžan, Katarina Trebušak Podkrajšek, Katja Goričar, 2023, objavljeni znanstveni prispevek na konferenci

Povzetek: Obsevanje je del standardnega zdravljenja bolnic z rakom dojk. Odgovor na zdravljenje z obsevanjem je pri vsakem posamezniku drugačen in je odvisen tudi od genetskih dejavnikov. Eden od novejših genetskih označevalcev odgovora na obsevanje je dolžina telomerov. Telomeri ščitijo kromosome pred krajšanjem in vzdržujejo genomsko stabilnost. Rezultati naše raziskave kažejo, da se dinamika spreminjanja dolžine telomerov takoj po zdravljenju z obsevanjem in v šestih mesecih po obsevanju pri bolnicah z neinvazivnim rakom dojk spreminja in bi lahko služila kot biološki označevalec odgovora na obsevanje. Molekularni mehanizmi, povezani s tem procesom, ostajajo zaenkrat večinoma neraziskani.
Ključne besede: rak dojk, obsevanje, onkološko zdravljenje
Objavljeno v DiRROS: 16.06.2023; Ogledov: 307; Prenosov: 123
.pdf Celotno besedilo (1,78 MB)
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42.
Fizikalni modeli imunoterapije in radioterapije
Damijan Valentinuzzi, Martina Vrankar, Katja Uršič Valentinuzzi, Mojca Unk, Olga Gordeeva, Alen Hadžić, Gregor Serša, Maja Čemažar, Robert Jeraj, 2023, objavljeni znanstveni prispevek na konferenci

Povzetek: V prispevku bomo predstavili rezultate fizikalnih modelov imunoterapije, ki smo jih razvili v programski skupini Medicinska fizika na Fakulteti za matematiko in fiziko Univerze v Ljubljani. Glavni cilj raziskav je bila prepoznava bioloških značilnosti tumorjev, od katerih je odvisen odziv na zdravljenje s protitelesi receptorja programirane celične smrti l (angl. anti-programmed-death-1 (anti-PD-1)). Posebno pozornost smo namenili meritvam modelskih parametrov ter preverbi rezultatov modeliranja, kar je eden izmed predpogojev za uspešno translacijo modeliranja v rutinsko predklinično in klinično prakso. Predstavili bomo tudi načrte za prihodnost, tj. modeliranje kombinacije anti-PD-1 in radioterapije.
Ključne besede: imunoterapija, radioterapija, medicinska fizika, tumorji
Objavljeno v DiRROS: 16.06.2023; Ogledov: 340; Prenosov: 93
.pdf Celotno besedilo (2,01 MB)

43.
Sustainable alkali-activated slag binders based on alternative activators sourced from mineral wool and glass waste
Majda Pavlin, Katja Koenig, Jakob Koenig, Uroš Javornik, Vilma Ducman, 2022, izvirni znanstveni članek

Povzetek: In the present study, four different locally available waste glass materials (bottle glass-BG, glass wool-GW, stone wool-SW and cathode-ray tube glass-CRTG) were treated with hot concentrated potassium hydroxide (KOH) in order to obtain alternative alkali activators (AAAs). We evaluated the suitability of the solutions obtained for use as AAAs in the production of AAMs. AAMs were prepared using electric arc furnace slag and selected AAAs with a higher content of dissolved Si. We evaluated the performance of the AAMs in comparison to that of slags activated with KOH or potassium-silicate (K-silicate). The compressive strength of the AAMs prepared with KOH-based AAAs were high when Si and Al were simultaneously abundant in the AAA (9.47 MPa when using the activator sourced from the CRTG), and low with the addition of KOH alone (1.97 MPa). The AAM produced using commercial K-silicate yielded the highest compressive strength (27.7 MPa). The porosity of the KOH-based AAM was lowest when an alternative BG-based activator was used (24.1%), when it was similar to that of the AAM prepared with a K-silicate. The BG-based activator had the highest silicon content (33.1 g/L), and NMR revealed that Si was present in the form of Q0, Q1 and Q2. The concentrations of toxic trace elements in the AAAs used for alkali activation of the slag were also determined, and leaching experiments were performed on the AAMs to evaluate the immobilisation potential of alkali-activated slag. In the SW AAAs the results show acceptable concentrations of trace and minor elements with respect to the regulations on waste disposal sites, while in the activators prepared from BG, CRTG and GW some elements exceeded the allowable limits (Pb, Ba, Sb, and As).
Ključne besede: alkali activated materials/geopolymers, alternative activators, NMR, leaching
Objavljeno v DiRROS: 08.06.2023; Ogledov: 296; Prenosov: 184
.pdf Celotno besedilo (2,26 MB)
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44.
Digitalization of culturally significant buildings: ensuring high-quality data exchanges in the heritage domain using OpenBIM
Laurens Jozef Nicolaas Oostwegel, Štefan Jaud, Sergej Muhič, Katja Malovrh Rebec, 2022, izvirni znanstveni članek

Povzetek: Cultural heritage building information models (HBIMs) incorporate specific geometric and semantic data that are mandatory for supporting the workflows and decision making during a heritage study. The Industry Foundation Classes (IFC) open data exchange standard can be used to migrate these data between different software solutions as an openBIM approach, and has the potential to mitigate data loss. Specific data-exchange scenarios can be supported by firstly developing an Information Delivery Manual (IDM) and subsequently filtering portions of the IFC schema and producing a specialized Model View Definition (MVD). This paper showcases the creation of a specialized IDM for the heritage domain in consultation with experts in the restoration and preservation of built heritage. The IDM was then translated into a pilot MVD for heritage. We tested our developments on an HBIM case study, where a historic building was semantically enriched with information about the case study’s conservation plan and then checked against the specified IDM requirements using the developed MVD. We concluded that the creation of an IDM and then the MVD for the heritage domain are achievable and will bring us one step closer to BIM standardisation in the field of digitised cultural buildings.
Ključne besede: HBIM, IFC, MVD, IDM, conservation plan, FOSS
Objavljeno v DiRROS: 07.06.2023; Ogledov: 241; Prenosov: 115
.pdf Celotno besedilo (2,06 MB)
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45.
Old buildings need new ideas : holistic integration of conservation-restoration process data using heritage building information modelling
Katja Malovrh Rebec, Boris Deanovič, Laurens Jozef Nicolaas Oostwegel, 2022, izvirni znanstveni članek

Povzetek: The preservation of cultural heritage and the renovation, restoration and remodelling processes could benefit greatly from Building Information Modelling (BIM) workflows being established. Currently, experts are involved with fractionated workflows, where a lot of data are missing, become lost or are duplicated by different stakeholders. All the resulting confusion severely impacts on the preservation of heritage as well as the efficiency of its restoring/remodelling/revitalizing from the point of view of current needs. Heritage information is usually conveyed through conservation-restoration plans and guidelines. In this research, a new methodology for managing the information holistically integrated into the BIM is proposed. The workflow is showcased on a demo-case building that is protected as cultural heritage. Consequently, the conservation plan becomes more accessible, not only for stakeholders in heritage, but also stakeholders responsible for the renovation, such as architects and contractors. This can result in an improved understanding of the heritage and a better revitalization.
Ključne besede: heritage building information modelling (HBIM), conservation plan, digitisation, revitalization
Objavljeno v DiRROS: 07.06.2023; Ogledov: 274; Prenosov: 215
.pdf Celotno besedilo (3,76 MB)
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46.
Antibacterial properties and cytotoxicity of 100% waste derived alkali activated materials : slags and stone wool-based binders
Caterina Sgarlata, Giovanni Dal Poggetto, Federica Piccolo, Michelina Catauro, Katja Traven, Mark Češnovar, Hoang Nguyen, Juho Yliniemi, Luisa Barbieri, Vilma Ducman, Isabella Lancellotti, Cristina Leonelli, 2021, izvirni znanstveni članek

Povzetek: In this study we compare the leaching behavior and the antibacterial and cytotoxic properties of 100% slag or stone wool derived alkali activated materials. The antibacterial activity was measured as the inhibiting capacity against two Gram- negative bacterial strains, Escherichia coli and Pseudomonas aeruginosa and one Gram-positive bacterial strain: Enterococcus faecalis. The cytotoxicity properties were tested on mouse embryonic fibroblast NIH-3T3 cell-line. It was proved that the high quality of the 3D aluminosilicate network of the consolidated materials obtained from powders of CaO or MgO-rich slags or stone wool, opportunely activated with NaO and/or Na-silicate, was capable of stabilizing heavy metal cations. The concentrations of leachate heavy cations were lower than the European law limit when tested in water. The effect of additives in the composites, basal fibers or nanocellulose, did not reduce the chemical stability and slightly influenced the compressive strength. Weight loss in water increased by 20% with basalt fibers addition, while it remained almost constant when nanocellulose was added. All the consolidated materials, cement-like in appearance, exhibited limited antibacterial properties (viability from 50 to 80% depending on the bacterial colony and the amount of sample) and absence of cytotoxicity, envisaging good acceptance from part of the final consumer and zero ecological impact. CaO-rich formulations can replace ordinary Portland cement (showing bacterial viability at 100%) with a certain capability for preventing the reproduction of the E. coli and S. aureus bacteria with health and environmental protection results.
Ključne besede: antibacterial properties, cytotoxicity, alkali-activated materials, slag, stone wool, waste utilization, social acceptance
Objavljeno v DiRROS: 22.05.2023; Ogledov: 288; Prenosov: 159
.pdf Celotno besedilo (2,31 MB)
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47.
Alkali activation of metallurgical slags : reactivity, chemical behavior, and environmental assessment
Isabella Lancellotti, Federica Piccolo, Katja Traven, Mark Češnovar, Vilma Ducman, Cristina Leonelli, 2021, izvirni znanstveni članek

Povzetek: Alkali-activated materials (AAMs) represent a promising alternative to conventional building materials and ceramics. Being produced in large amounts as aluminosilicate-rich secondary products, such as slags, they can be utilized for the formulation of AAMs. Slags are partially crystalline metallurgical residues produced during the high temperature separation of metallic and non-metallic materials in the steelmaking processes. In the present study, the electric arc furnace carbon or stainless steel slag (EAF) and secondary metallurgical slag such as ladle furnace basic slag (LS) were used as precursors in an alkali-activation process. EAF slag, with its amorphous fraction of about 56%, presented higher contents of soluble Si and Al species with respect to ladle slag R (35%). However, both are suitable to produce AAM. The leaching behavior shows that all the release values are below the regulation limit. All the bivalent ions (Ba, Cd, Cu, Ni, Pb, and Zn) are well immobilized in a geopolymeric matrix, while amphoteric elements, such as As and Cr, show a slight increase of release with respect to the corresponding slag in alkaline and aqueous environments. In particular, for Sb and As of AAM, release still remains below the regulation limits, while Mo presents an increase of leaching values that slightly exceeds the limit for landfill non-dangerous waste.
Ključne besede: slag, aluminosilicate materials, chemical reactivity, cold consolidation, alkali activation, leaching test, open access
Objavljeno v DiRROS: 22.05.2023; Ogledov: 296; Prenosov: 154
.pdf Celotno besedilo (4,49 MB)
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48.
Zdravljenje z zaviralcem imunskih kontrolnih točk pri bolniku s ploščatoceličnim karcinomom kože in mielofibrozo : prikaz primera
Katja Leskovšek, Janja Ocvirk, 2023, objavljeni znanstveni prispevek na konferenci

Povzetek: Imunosupresija je eden najpomembnejših dejavnikov tveganja za pojav ploščatoceličnega karcinoma kože. Tveganje je največje pri bolnikih po presaditvi solidnih organov, sledijo bolniki s presaditvijo kostnega mozga, okuženi s HIV in bolniki na imunosupresivnem zdravljenju s kemoterapijo, tarčnimi ali biološkimi zdravili. Običajno razvijejo multiple in recidivne ploščatocelične karcinome kože. Zdravljenje s kirurgijo in radioterapijo je pogosto neučinkovito in lahko povzroči pomembno morbiditeto, vodi v zmanjšano funkcijo organa ter posledično slabšo kvaliteto življenja. Bolniki imajo podvojeno tveganje za razsoj v oddaljene organe. Prognoza imunosuprimiranih bolnikov s ploščatoceličnim karcinomom kože je slabša. Na voljo so omejeni podatki o zdravljenju teh bolnikov z zaviralci imunskih kontrolnih točk kot so zaviralci PD-1.
Ključne besede: rak kože, melanom, sistemsko zdravljenje
Objavljeno v DiRROS: 18.05.2023; Ogledov: 265; Prenosov: 124
.pdf Celotno besedilo (437,44 KB)
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49.
50.
12 priporočil proti raku in vzpodbujanje zdravstvene pismenosti na področju preprečevanja raka
Katja Jarm, 2022, objavljeni strokovni prispevek na konferenci

Ključne besede: preventiva proti raku, zdravo življenje, priporočila
Objavljeno v DiRROS: 15.02.2023; Ogledov: 274; Prenosov: 85
.pdf Celotno besedilo (591,13 KB)

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