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Population differentiation in Acer platanoides L. at the regional scale—laying the basis for effective conservation of its genetic resources in Austria
Desanka Lazarević, Jan-Peter George, Mari Rusanen, Dalibor Ballian, Stefanie Pfattner, Konrad Heino, 2022, izvirni znanstveni članek

Povzetek: Norway maple (Acer platanoides L.) is a widespread forest tree species in Central and Northern Europe but with a scattered distribution. In the debate on climate change driven changes in species selection in the forest, Norway maple has recently received raised interest because of its comparatively high drought resistance (higher than in sycamore maple). Therefore, it is an interesting species for sites high in carbonates and where other native tree species have become devastated by pathogens (e.g., elm, ash). In Austria, the demand on saplings is currently rising, while there is only very little domestic reproductive material available (on average more than 95% of saplings are imported from neighboring countries). This study was undertaken to identify genetic diversity and population structure of Norway maple in Austria to lay the foundation for the establishment of respective in situ and ex situ conservation measures. In addition, samples from planted stands and imported reproductive material from other countries were included to study the anthropogenic influence on the species in managed forests. We used 11 novel microsatellites to genotype 756 samples from 27 putatively natural Austrian populations, and 186 samples derived from two planted stands and five lots of forest reproductive material; in addition, 106 samples from other European populations were also genotyped. Cross species amplification of the new markers was tested in 19 Acer species from around the world. Population clustering by STRUCTURE analysis revealed a distinct pattern of population structure in Austria and Europe, but overall moderate differentiation. Sibship analysis identifies several populations with severe founding effects, highlighting the need for proper selection of seed sources of sufficient genetic diversity in the species.
Ključne besede: Norway maple, genetic structure, genetic differentiation, gene pool, seed orchard
Objavljeno v DiRROS: 26.04.2022; Ogledov: 192; Prenosov: 120
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Repository of drought event impacts across the danube catchment countries between 1981 and 2016 using publicly available sources
Jiří Jakubínský, Monika Bláhová, Lenka Bartošová, Klára Steinerová, Jan Balek, Petra Dížková, Daniela Semerádová, Daniel Alexandru, Galia Bardarska, Sabina Bokal, Gregor Gregorič, Gal Oblišar, Andreja Sušnik, 2019, izvirni znanstveni članek

Povzetek: Drought directly and indirectly affects human society in a number of ways. In many regions of the world climate change will exasperate the effects of droughts, affect national economies more intensely. The main aim of this article was to catalogue and analyze the drought impacts in the 11 Central and South Eastern European states located in the Danube river basin. The identification of dry episodes was based on information from publicly available sources, namely, newspaper and journal articles that reported drought impacts. Information on drought impact occurrences was classified into one of five defined categories in which the drought impact report was most clearly manifested (i.e., agriculture, forestry, soil systems, wildfires and hydrology). In terms of the spatial distribution of drought impacts, individual recorded events were analyzed at the level of EU NUTS regions (or their equivalent in non-EU countries). The analysis highlights country-specific vulnerability to drought. Furthermore, gradual increases in drought events and the number of reported impacts were identified, which was particularly evident in the agricultural sector.
Ključne besede: drought impact, Danube basin, agriculture, climate change, water stress
Objavljeno v DiRROS: 21.04.2022; Ogledov: 255; Prenosov: 110
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Covid-19 pulmonary pathology : the experience of European pulmonary pathologists throughout the first two waves of the pandemic
Francesco Fortarezza, Federica Pezzuto, Paul Hofman, Izidor Kern, Angel Panizo, Jan von der Thüsen, Sergei Timofeev, Gregor Gorkiewicz, Sabina Berezowska, Laurence de Level, Cristian Ortiz-Villalón, Francesca Lunardi, Fiorella Calabrese, 2022, izvirni znanstveni članek

Povzetek: Autoptic studies of patients who died from COVID-19 constitute an important step forward in improving our knowledge in the pathophysiology of SARS-CoV-2 infection. Systematic analyses of lung tissue, the organ primarily targeted by the disease, were mostly performed during the first wave of the pandemic. Analyses of pathological lesions at different times offer a good opportunity to better understand the disease and how its evolution has been influenced mostly by new SARS-CoV-2 variants or the different therapeutic approaches. In this short report we summarize responses collected from a questionnaire survey that investigated important pathological data during the first two pandemic waves (spring-summer 2020; autumn-winter 2020–2021). The survey was submitted to expert lung pathologists from nine European countries involved in autoptic procedures in both pandemic waves. The frequency of each lung lesion was quite heterogeneous among the participants. However, a higher frequency of pulmonary superinfections, both bacterial and especially fungal, was observed in the second wave compared to the first. Obtaining a deeper knowledge of the pathological lesions at the basis of this complex and severe disease, which change over time, is crucial for correct patient management and treatment. Autoptic examination is a useful tool to achieve this goal.
Ključne besede: COVID-19, SARS-CoV-2, autopsy, lung - pathology, pulmonary aspergillosis
Objavljeno v DiRROS: 13.01.2022; Ogledov: 347; Prenosov: 193
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Genetic aspects linked to production and use of forest reproductive material (FRM) : collecting scientific evidence for developing guidelines and decision support tools for effective FRM management
Dušan Gömöry, Katri Himanen, Mari Mette Tollefsrud, Claes Uggla, Hojka Kraigher, Sandor Bordacs, Paraskevi Alizoti, Stuart A'Hara, Aline Frank, Gunnar Friis Proschowsky, Josef Frýdl, Thomas Geburek, Monique Guibert, Mladen Ivanković, Ana Jurše, Stuart Kennedy, Jan Kowalczyk, Heike Liesebach, Tiit Maaten, Andrej Pilipović, Roberta Proietti, Volker Schneck, Alain Servais, Brynjar Skúlason, Christoph Sperisen, Frank Wolter, Tefide Yüksel, Michele Bozzano, 2021, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid

Povzetek: This report summarises the current state of knowledge in genetic aspects linked to the production and use of forest reproductive material (FRM). The first chapter describes the different categories of FRM, considers the strategic choice between artificial and natural regeneration in the face of climate change, and articulates the need for and purposes of FRM. Chapter 2 outlines the FRM production chain, in terms of: i) FRM approval, management, collection and certification (seed sources, stands, orchards, plus trees and clones others); ii) Testing standards and examples; iii) Effect of seed and seedling material not intended for use as FRM on forest genetic resources; iv) Breeding effects on basic material including conservation strategy; v) Harvesting, processing and storage of seeds; vi) Nursery practices; vii) Certification and Traceability; and viii) FRM Trading and Transport. Chapter 3 examines FRM with regard to: i) Forest regeneration strategies % especially considering climate change, and ii) Assisted migration and available decision support tools. Chapter 4 provides a detailed overview of forest establishment methods, and chapter 5 looks at keeping records of seed origin to improve forest management. The final chapter offers 38 recommendations arising from the review. This work is the result of an international collaboration rooted in EUFORGEN for more than two decades. It is built on the firm belief that the genetic element is decisive for the creation of a resilient forest capable of surviving threats and adapting to changes, thus enabling the evolution of ecosystems and the conservation of the productive landscape.
Ključne besede: forest reproductive material
Objavljeno v DiRROS: 05.11.2021; Ogledov: 422; Prenosov: 226
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Somatic mutations and the risk of undifferentiated autoinflammatory disease in MDS : an under-recognized but prognostically important complication
Abdulla Watad, Mark Kačar, Nicola Luigi Bragazzi, Qiao Zhou, Miriam Jassam, Jan Taylor, Eve Roman, Alexandra Smith, Richard A. Jones, Howard Amital, 2021, izvirni znanstveni članek

Povzetek: Objectives: We theorized that myelodysplastic syndrome (MDS) with somatic mutations and karyotype abnormalities are associated with autoinflammation, and that the presence of autoinflammatory disease affected prognosis in MDS. Methods: One hundred thirty-four MDS patients were assessed for the prevalence of autoinflammatory complications and its link with karyotypes and somaticmutation status. Autoinflammatory complications were described either as well-defined autoinflammatory diseases (AD) or undifferentiated "autoinflammatory disease" (UAD) (defined as CRP over 10.0 mg/L on five consecutive occasions, taken at separate times and not explained by infection). Several patient characteristics including demographic, clinical, laboratory, cytogenetics charts, and outcomes, were compared between different groups. Results: Sixty-two (46.3%) patients had an autoinflammatory complication manifesting as arthralgia (43.5% vs. 23.6%, p = 0.0146), arthritis (30.6% vs. 15.3%, p = 0.0340), skin rash (27.4% vs. 12.5%, p = 0.0301), pleuritis (14.5% vs. 4.2%, p = 0.0371) and unexplained fever (27.4% vs. 0%, p < 0.0001). AD were found in 7.4% of MDS patients (with polymyalgia rheumatic being the most frequently one). Classical autoimmune diseases were found only in 4 MDS patients (3.0%). Transcription factor pathway mutations (RUNX1, BCOR, WTI, TP53) (OR 2.20 [95%CI 1.02-4.75], p = 0.0451) and abnormal karyotypes (OR 2.76 [95%CI 1.22-6.26], p = 0.0153) were associated with autoinflammatory complications. Acute leukaemic transformation was more frequent in MDS patients with autoinflammatory features than those without (27.4% vs. 9.7%, p = 0.0080). Conclusions: Autoinflammatory complications are common inMDS. Somatic mutations of transcription factor pathways and abnormal karyotypes are associated with greater risk of autoinflammatory complications, which are themselves linked to malignant transformation and a worse prognosis.
Ključne besede: myelodysplastic syndromes - genetics, autoinflammation, undifferentiated autoinflammatory disease, molecular characterization, somatic mutations
Objavljeno v DiRROS: 31.03.2021; Ogledov: 658; Prenosov: 402
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Global guidelines for the sustainable use of non-native trees to prevent tree invasions and mitigate their negative impacts
Giuseppe Brundu, Aníbal Pauchard, Petr Pyšek, Jan Pergl, Anja M. Bindewald, Antonio Brunori, Susan Canavan, Thomas Campagnaro, Laura Celesti-Grapow, Michele de Sá Dechoum, Marjana Westergren, 2020, izvirni znanstveni članek

Povzetek: Sustainably managed non-native trees deliver economic and societal benefits with limited risk of spread to adjoining areas. However, some plantations have launched invasions that cause substantial damage to biodiversity and ecosystem services, while others pose substantial threats of causing such impacts. The challenge is to maximise the benefits of non-native trees, while minimising negative impacts and preserving future benefits and options. A workshop was held in 2019 to develop global guidelines for the sustainable use of non-native trees, using the Council of Europe % Bern Convention Code of Conduct on Invasive Alien Trees as a starting point. The global guidelines consist of eight recommendations: 1) Use native trees, or non-invasive non-native trees, in preference to invasive non-native trees; 2) Be aware of and comply with international, national, and regional regulations concerning non-native trees; 3) Be aware of the risk of invasion and consider global change trends; 4) Design and adopt tailored practices for plantation site selection and silvicultural management; 5) Promote and implement early detection and rapid response programmes; 6) Design and adopt tailored practices for invasive non-native tree control, habitat restoration, and for dealing with highly modified ecosystems; 7) Engage with stakeholders on the risks posed by invasive non-native trees, the impacts caused, and the options for management; and 8) Develop and support global networks, collaborative research, and information sharing on native and non-native trees. The global guidelines are a first step towards building global consensus on the precautions that should be taken when introducing and planting non-native trees. They are voluntary and are intended to complement statutory requirements under international and national legislation. The application of the global guidelines and the achievement of their goals will help to conserve forest biodiversity, ensure sustainable forestry, and contribute to the achievement of several Sustainable Development Goals of the United Nations linked with forest biodiversity.
Ključne besede: biological invasions, code of conduct, environmental policy and legislation, invasion science, stakeholder engagement, stakeholder participation, sustainable forestry
Objavljeno v DiRROS: 26.01.2021; Ogledov: 754; Prenosov: 438
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Decrease in cellular nanovesicles concentration in blood of athletes more than 15 hours after marathon
Zala Jan, Mitja Drab, Damjana Drobne, Apolonija Bedina Zavec, Mojca Benčina, Barbara Drašler, Matej Hočevar, Judita Lea Krek, Ljubiša Pađen, Manca Pajnič, Neža Repar, Boštjan Šimunič, Roman Štukelj, Veronika Kralj-Iglič, 2021, izvirni znanstveni članek

Povzetek: Introduction: Cellular nanovesicles (CNVs), that are shed from cells, have been recognized as promising indicators of health status. We analyzed the effect of long-distance running on concentration of CNVs, along with some standard blood parameters, in 27 athletes two days before and > 15 hours after physical effort. Methods: CNVs were isolated by repetitive centrifugation and washing of samples, and assessed by flow cytometry. Cholinesterase (ChE) and glutathione S-transferase (GST) activity were measured spectrophotometrically. Interleukin 6 (IL-6) and tumor necrosis factor-% (TNF-%) concentrations were measured using enzyme-linked immunosorbent assay (ELISA). C-reactive protein (CRP) was measured with immunoturbidimetric determination and lipidogram parameters were measured by enzymatic colorimetric assay. Flow cytometry was used for blood cell count and mean platelet volume (MPV) measurement. Results: More than 15 hours after physical effort a decrease was found in CNVs% concentration in isolates from blood (46%; p< 0.05), in ChE activity in whole blood (47%; p< 0.001), in plasma (34%; p< 0.01), and in erythrocyte suspension (54%; p< 0.001), as well as in GST activity in erythrocyte suspension (16%; p< 0.01) and in IL-6 concentration in plasma (63%; p< 0.05). We found no change in GST activity in plasma and in TNF-% concentration in plasma. Correlations (> 0.8; p< 0.001) between CNVs% concentration and ChE activity, and GST activity, respectively, in erythrocyte suspension were found. Conclusion: We found that > 15 hours post-physical effort, CNVs% concentration was below the initial value, concomitant with other measured parameters: ChE and GST activity as well as IL-6 concentration, indicating a favorable effect of physical effort on health status. CNVs% concentration and ChE activity in isolates from peripheral blood proved to have potential as indicators of the response of the human body to inflammation after physical effort. Physical activity should be considered as an important factor in preparation of subjects for blood sampling in procedures focusing on CNV-containing diagnostic and therapeutic compounds.
Ključne besede: membrane vesiculation, physical effort, blood samples, inflammation process, cellular nanovesicles, marathon
Objavljeno v DiRROS: 25.01.2021; Ogledov: 767; Prenosov: 531
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Platformne storitve
Ana Robnik, Andrej Ciglič, Aleš Balanč, Dušan Gabrijelčič, Jan Porekar, Arso Savanović, Polona Škraba, Roman Kužnar, Ignac Zupan, 2015, objavljeni znanstveni prispevek na konferenci

Objavljeno v DiRROS: 08.12.2020; Ogledov: 844; Prenosov: 252
.pdf Celotno besedilo (608,68 KB)

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