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Tarčna terapija in imunoterapija pljučnega raka
Tanja Čufer, Lea Knez, 2015

Keywords: pljučni rak, tarčna terapija, imunoterapija
DiRROS - Published: 08.05.2020; Views: 940; Downloads: 286
.pdf Fulltext (279,29 KB)

Immunotherapy for metastatic non-small cell lung cancer : real-world data from an academic Central and Eastern European center
Marija Ivanović, Lea Knez, Ana Herzog, Mile Kovačević, Tanja Čufer, 2021

Abstract: Background. Immunotherapy with immune checkpoint inhibitors (ICIs) recently became the standard treatment for patients with advanced non-small cell lung cancer (NSCLC). Here, we present the first results of a real-world observational study on the effectiveness of ICI monotherapy in patients with advanced NSCLC treated at a single academic center in a Central and Eastern European (CEE) country. Materials and methods. Overall, 66 consecutive patients with advanced NSCLC treated with ICIs in everyday clinical practice, either with first-line pembrolizumab (26 patients) or second-line atezolizumab, nivolumab, or pembrolizumab (40 patients), from August 2015 to November 2018, were included. All data were retrieved from a hospital lung cancer registry, in which the data is collected prospectively. Results. Included patients had a median age of 64 years, most were male (55%), 6% were in performance status >/=2, and 18% had controlled central nervous system metastases at baseline. In first-line, the median progression-free survival (mPFS) was 9.3 months, while the median overall survival (mOS) was not reached. The 1-year overall survival (OS) was 62%. In second-line, the mPFS and mOS were 3.5 months and 9.9 months, respectively, with a 1-year OS of 35%. In the overall population, adverse events of any grade were recorded in 79% of patients and of severe grade (3-4) in 12% of patients. Conclusion. The first real-world outcomes of NSCLC immunotherapy from a CEE country suggest comparable effectiveness to those observed in clinical trials and other real-world series, mainly coming from North America and Western European countries. Further data to inform on the real-world effectiveness of immunotherapy worldwide are needed.
Keywords: non-small cell lung carcinoma, immunotherapy, advanced non-small cell lung cancer, real-world data, Central Europe, Europe, Eastern Europe
DiRROS - Published: 12.10.2021; Views: 301; Downloads: 69

Decrease in cellular nanovesicles concentration in blood of athletes more than 15 hours after marathon
Mojca Benčina, Apolonija Bedina Zavec, Damjana Drobne, Mitja Drab, Zala Jan, Barbara Drašler, Matej Hočevar, Judita Lea Krek, Ljubiša Pađen, Manca Pajnič, Neža Repar, Boštjan Šimunič, Roman Štukelj, Veronika Kralj-Iglič, 2021

Abstract: Introduction: Cellular nanovesicles (CNVs), that are shed from cells, have been recognized as promising indicators of health status. We analyzed the effect of long-distance running on concentration of CNVs, along with some standard blood parameters, in 27 athletes two days before and > 15 hours after physical effort. Methods: CNVs were isolated by repetitive centrifugation and washing of samples, and assessed by flow cytometry. Cholinesterase (ChE) and glutathione S-transferase (GST) activity were measured spectrophotometrically. Interleukin 6 (IL-6) and tumor necrosis factor-% (TNF-%) concentrations were measured using enzyme-linked immunosorbent assay (ELISA). C-reactive protein (CRP) was measured with immunoturbidimetric determination and lipidogram parameters were measured by enzymatic colorimetric assay. Flow cytometry was used for blood cell count and mean platelet volume (MPV) measurement. Results: More than 15 hours after physical effort a decrease was found in CNVs% concentration in isolates from blood (46%; p< 0.05), in ChE activity in whole blood (47%; p< 0.001), in plasma (34%; p< 0.01), and in erythrocyte suspension (54%; p< 0.001), as well as in GST activity in erythrocyte suspension (16%; p< 0.01) and in IL-6 concentration in plasma (63%; p< 0.05). We found no change in GST activity in plasma and in TNF-% concentration in plasma. Correlations (> 0.8; p< 0.001) between CNVs% concentration and ChE activity, and GST activity, respectively, in erythrocyte suspension were found. Conclusion: We found that > 15 hours post-physical effort, CNVs% concentration was below the initial value, concomitant with other measured parameters: ChE and GST activity as well as IL-6 concentration, indicating a favorable effect of physical effort on health status. CNVs% concentration and ChE activity in isolates from peripheral blood proved to have potential as indicators of the response of the human body to inflammation after physical effort. Physical activity should be considered as an important factor in preparation of subjects for blood sampling in procedures focusing on CNV-containing diagnostic and therapeutic compounds.
Keywords: membrane vesiculation, physical effort, blood samples, inflammation process, cellular nanovesicles, marathon
DiRROS - Published: 25.01.2021; Views: 692; Downloads: 476
.pdf Fulltext (1,88 MB)

Medicinske osnove kardiorespiratorne fizioterapije : univerzitetni učbenik
Lea Andjelkovič, 2019

Abstract: Respiratorna fizioterapija je zdravstvena veja, ki obravnava bolnike z akutno in kronično okvaro dihal. Respiratorni terapevt pod nadzorom zdravnika z različnimi fizikalnimi metodami, invazivnimi in neinvazivnimi, neguje in zdravi kardiorespiratorne bolnike. Področje delovanja in metode respiratorne obravnave bolnikov so zelo obsežni, namen tega učbenika pa je, da z njimi seznanimo študente.
Keywords: elektronske knjige
DiRROS - Published: 22.11.2019; Views: 1554; Downloads: 382
.pdf Fulltext (3,15 MB)

Medicinske osnove kardiorespiratorne fizioterapije : univerzitetni učbenik
Lea Andjelkovič, 2019

DiRROS - Published: 02.06.2020; Views: 1047; Downloads: 371
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Vloga HPV pri nastanku raka materničnega vratu
Mario Poljak, Lea Hošnjak, 2018

Keywords: rak materničnega vratu, HPV, genotipi
DiRROS - Published: 08.05.2020; Views: 832; Downloads: 290
.pdf Fulltext (61,80 KB)

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