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Lower tumour burden and better overall survival in melanoma patients with regional lymph node metastases and negative preoperative ultrasound
Gašper Pilko, Janez Žgajnar, Maja Marolt-Mušič, Marko Hočevar, 2012, original scientific article

Abstract: Background. The purpose of the study was to evaluate the ability of ultrasound(US) and fine needle aspiration biopsy (FNAB) in reducing the numberof melanoma patients requiring a sentinel node biopsy (SNB); to compare the amount of metastatic disease in regional lymph nodes in SNB candidates with clinically uninvolved lymph nodes and of those with US uninvolved lymph nodes; and to compare the overall survival (OS) of both groups. Methods. Between 2000 and 2007, a SNB was successfully performed in 707 patients with melanoma. The preoperative US of the regional lymph node basins was performed in 405 SNB candidates. In 14 of these patients, the US-guided FNAB was positive and they proceeded directly to lymph node dissection. In 391 patients, the preoperative US was either negative (343 patients) or suspicious(48 patients) (US group). In the remaining 316 patients the preoperative US was not performed (non-US group). Results. The proportion of macrometastatic sentinel lymph nodes (SN), number of metastatic lymph nodes per patient and proportion of nonsentinel lymph node metastases were found to be lower in the US group compared to the non-US group. The smaller tumour burden of the US group was reflected in a significantly better OS of patients with SN metastases. Conclusions. The preoperative US of regional lymph nodes spares some patients with melanoma from undergoing a SNB. Patients with regional metastases and a negative preoperative US have a significantly lower tumour burden in comparison to those with clinically negative lymph nodes, which is also reflected in a better OS.
Published in DiRROS: 22.03.2024; Views: 45; Downloads: 17
.pdf Full text (466,54 KB)

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Inguinal or inguino-iliac/obturator lymph node dissection after positive inguinal sentinel lymph node in patients with cutaneous melanoma
Nebojša Glumac, Marko Hočevar, Vesna Zadnik, Marko Snoj, 2012, original scientific article

Abstract: The aim of the study was to determine whether the presence of inguinal sentinel lymph node (SLN) metastases smaller than 2 mm (micrometastases) subdivided according to the number of micrometastases predicts additional, non-sentinel inguinal, iliac or obturator lymph node involvement in completion lymph node dissection (CLND). Positive inguinal SLN was detected in 58 patients (32 female, 26 male, median age 55 years) from 743 consecutive and prospectively enrolled patients with primary cutaneous melanoma stage I and II who were treated with SLN biopsy between 2001 and 2007. Micrometastases in inguinal SLN were detected in 32 patients, 14 were single, 2 were double, and 16 were multiple. Twenty-six patients had macrometastases. No patient with any micrometastases or a single SLN macrometastasis in the inguinal region had any iliac/obturator non-sentinel metastases after CLND in our series. Furthermore, no patient with single SLN micrometastasis in the inguinal region had any non-sentinel metastases at all after CLND in our series. In these cases respective CLND might be omitted.
Published in DiRROS: 21.03.2024; Views: 48; Downloads: 19
.pdf Full text (307,79 KB)

5.
Outcome of MRI-guided vacuum-assisted breast biopsy - initial experience at Institute of Oncology Ljubljana, Slovenia
Marta Zebič, Kristijana Hertl, Maksimiljan Kadivec, Miha Čavlek, Gašper Podobnik, Marko Snoj, 2012, original scientific article

Abstract: Background. Like all breast imaging modalities MRI has limited specificity and the positive predictive value for lesions detected by MRI alone ranges between 15 and 50%. MRI guided procedures (needle biopsy, presurgical localisation) are mandatory for suspicious findings visible only at MRI, with potential influence on therapeutic decision. The aim of this retrospective study was to evaluate our initial clinical experience with MRI-guided vacuum-assisted breast biopsy as an alternative to surgical excision and to investigate the outcome of MRI-guided breast biopsy as a function of the MRI features of the lesions. Patients and methods. In 14 women (median age 51 zears) with 14 MRI-detected lesions, MRI-guided vacuum-assisted breast biopsy was performed. We evaluated the MRI findings that led to biopsy and we investigated the core and postoperative histology results and follow-up data. Results. The biopsy was technically successful in 14 (93%) of 15 women. Of 14 biopsies in 14 women, core histology revealed 6 malignant (6/14, 43%), 6 benign (6/14, 43%) and 2 high-risk (2/14, 14%) lesions. Among the 6 cancer 3 were invasive and 3 were ductal carcinoma in situ (DCIS). The probability of malignancy in our experience was higher for non-mass lesion type and for washout and plateau kinetics. Conclusions. Our initial experience confirms that MRI-guided vacuum-assisted biopsy is fast, safe and accurate alternative to surgical biopsy for breast lesions detected at MRI only.
Published in DiRROS: 21.03.2024; Views: 50; Downloads: 20
.pdf Full text (617,87 KB)

6.
Dimeric structures of DNA ATTTC repeats promoted by divalent cations
Marko Trajkovski, Annalisa Pastore, Janez Plavec, 2024, original scientific article

Published in DiRROS: 20.03.2024; Views: 56; Downloads: 31
.pdf Full text (1,49 MB)
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The core of a vertex transitive complementary prism of a lexicographic product
Marko Orel, 2023, original scientific article

Abstract: The complementary prism of a graph $\Gamma$ is the graph $\Gamma \overline{\Gamma}$, which is formed from the union of $\Gamma$ and its complement $\overline{\Gamma}$ by adding an edge between each pair of identical vertices in $\Gamma$ and $\overline{\Gamma}$. Vertex-transitive self-complementary graphs provide vertex-transitive complementary prisms. It was recently proved by the author that $\Gamma \overline{\Gamma}$ is a core, i.e. all its endomorphisms are automorphisms, whenever $\Gamma$ is vertex-transitive, self-complementary, and either $\Gamma$ is a core or its core is a complete graph. In this paper the same conclusion is obtained for some other classes of vertex-transitive self-complementary graphs that can be decomposed as a lexicographic product $\Gamma = \Gamma_1 [\Gamma_2]$. In the process some new results aboutthe homomorphisms of a lexicographic product are obtained.
Keywords: graph homomorphism, core, complementary prism, self-complementary graph, vertex-transitive graph, lexicographic product
Published in DiRROS: 19.03.2024; Views: 49; Downloads: 28
.pdf Full text (411,68 KB)
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Is there any progress in routine management of lung cancer patients? A comparative analysis of an institution in 1996 and 2006
Lučka Debevec, Tina Jerič, Viljem Kovač, Marko Bitenc, Mihael Sok, 2009, original scientific article

Abstract: Background. The aim of the study was to establish eventual progress in routine management of lung cancer patients over a ten-year period at University Clinic for Respiratory and Allergic Diseases Golnik, Slovenia, comparing the results of analysis of 345 patients, diagnosed in 1996 (with analysis performed in 2002), and 405 patients, diagnosed in 2006 (with analysis performed in 2008).Patients and methods. The patients of both analysed groups were of comparable age and number of patients in stage I and II, but there were relatively more females, patients with better performance status, more precise clinical staging and tumour histology in the 2006 group. The parameters used for assessing the progress of management were as follows: time period from admittance to diagnosis and to surgery; precision of staging; accordance of clinical and pathological staging in resected patients; percentage of exploratory thoracotomy; and use of new treatment modalities. The proportion of patients in selected/actual primary treatment modality and survival rate could also be used for assessing the progress. Results. Althoughunessential longer time from admittance to microscopic confirmed diagnosis increased from a mean 7.4 to 8.6 days in 2006 progress was established by the following: more precise clinical staging (stage I and II also A and B stage, TNM staging also in small-cell lung cancer patients); improved accordance with clinical and pathological staging in resected patients (46% against 58%); decreased percentage of exploratory thoracotomy (13% against 4%); increased use of multimodality therapy as primary treatment modality (radiotherapy/chemotherapy, neoadjuvant chemotherapy); newly performed radio frequency tumour ablation. The proportion in selected/actual surgery increased from 76% to 93% and median survival rate of all patients from 6.2 to 10.6 months. (Abstract truncated at 2000 characters)
Published in DiRROS: 08.03.2024; Views: 70; Downloads: 22
.pdf Full text (80,75 KB)

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