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Query: "author" (Ga��perlin Tanja) .

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21.
Description, identification, and growth of Tuber borchii Vittad. mycorrhized Pinus sylvestris L. seedlings on different lime contents
Tanja Mrak, Tine Grebenc, Silke Friedrich, Babette Münzenberger, 2024, original scientific article

Abstract: Tuber borchii forms ectomycorrhiza with oaks, hazel, and pines, including Pinus sylvestris. However, its ectomycorrhiza morphotype with P. sylvestris was not comprehensively described so far, and molecular analyses are missing despite a high danger of misidentification of T. borchii ectomycorrhiza with other closely related and less valuable truffle species. We described for the first time the morphology and anatomy of T. borchii-P. sylvestris ectomycorrhiza using differential interference contrast technique and semi-thin sections in combination with molecular confirmation of identity. Color of ectomycorrhiza is reddish to dark brown, and morphotypes are unevenly but densely covered by warts-bearing pin-like cystidia. All layers of the hyphal mantle are pseudoparenchymatous with outer mantle layer formed of epidermoid cells. T. borchii ectomycorrhiza was identified by a molecular comparison with fruitbodies used for inoculation and its respective ectomycorrhizae. T. borchii has a wide ecological amplitude. To get a better insight in mycorrhization requirements, we investigated growth of P. sylvestris and its ectomycorrhiza infection rate with T. borchii in substrate with different lime content. The mycorrhization of P. sylvestris with T. borchii in the mycorrhization substrate and cultivation in greenhouse conditions was successful, with colonization of P. sylvestris varying between 36.5 and 48.1%. There was no significant correlation of mycorrhization to applied lime contents, and consequently to pH in substrate, while the increased levels of lime improved growth of the P. sylvestris seedlings.
Keywords: root anatomy, ectomycorrhiza, Limestone content, molecular identification, Pinus sylvestris, Tuber borchii
Published in DiRROS: 22.01.2024; Views: 183; Downloads: 84
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22.
Prognostic relevance of urokinase plasminogen activator and its inhibitors in patients with breast cancer
Simona Borštnar, Tanja Čufer, Ivan Vrhovec, Zvonimir Rudolf, 1999, original scientific article

Abstract: Urokinase plasminogen activator (uPA) and its inhibitors, PAI-1 and PAI-2, play an important role in iritercellular tissue degradation, thus promoting tumor cell invasion into the adjoining structures and metastasizing. Our studywas aimed to assess a possible prognostic value of uPA, PAI-1 and PAI-2 in a retrospective series of 87 patients with breast cancer stage I-III, whosecytosols were stored in the archives of the, Institute of Oncology in Ljubljana. The median follow-up was 35 months. The prognostic value of the established prognostic factors and uPA, PAI-1 and PAI-2 were evaluated by means of univariate statistical analysis and partial multivariate models. The obtained uPA values were very low and did not correlate with the disease free survival, whereas PAI-1 and PAI-2 significantly influenced the time to the first recurrence. Patients with PAI-1 values above 5 ng/mg proteins had statistically significantly worse disease free survival than the patients withlower PAI-1 values (58% vs. 85%). In the case of PAI-2, the situation wasjust the opposite: the patients with PAI-2 values exceeding 6.4 ng/mg proteins had statistically significantly better 3-year disease free survival than the patients with lower values (90% vs. 60%). Both, PAI-1 and PAl-2 retained their independent prognostic value, irrespective of the addition of the established prognostic factors to partial multivariate models, and only with locally advanced disease the prognostic value of PAI-1 was greater than that of PAI-2.
Published in DiRROS: 22.01.2024; Views: 154; Downloads: 39
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23.
The urokinase-type plasminogen activator, its inhibitors and its receptor - the new prognostic factors in solid cancers
Simona Borštnar, Tanja Čufer, Zvonimir Rudolf, 1997, review article

Abstract: The urokinase-type plasminogen activator (uPA), its inhibitors (PAI-1 and PAI-2) and its receptor (uPAR) play nan important role in the degradation of the intercellular tissue, the process which affects the ability of cancer cells to invade to surrounding tissue and to metastasize. The results of clinical studies performed in the past few years point out a significant influence of uPA, PAI-1, PAI-2 and uPAR on the course of the disease and survival of patients with solid tumours, particularly breast cancer. Hopefullythe categorization of patients according to the content of the serineproteases and its inhibitors in tumour tissues could provide a basis formore rational treatment planning and thus improving patients' survival.
Published in DiRROS: 18.01.2024; Views: 128; Downloads: 38
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Preface
Tanja Čufer, Marjan Budihna, 1997, preface, editorial, afterword

Published in DiRROS: 16.01.2024; Views: 114; Downloads: 36
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26.
Prognostic factors in breast cancer
Tanja Čufer, 1995, professional article

Keywords: dojke, rak (medicina), prognoza
Published in DiRROS: 15.01.2024; Views: 121; Downloads: 30
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Survival and disease-free interval of malignant melanoma patients in relation to the prognostic factors
Zvonimir Rudolf, Tanja Roš-Opaškar, 1992, original scientific article

Keywords: rak (medicina), kožni rak, melanom, prognoza
Published in DiRROS: 09.01.2024; Views: 130; Downloads: 41
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30.
Povezanost med rakom in onesnaževali, ki nastanejo v procesih sežiga in sosežiga odpadkov: krovni pregled literature
Teja Oblak, Tanja Carli, Vesna Zadnik, Niko Samec, Andreja Kukec, 2023, review article

Abstract: Izhodišča: V procesih sežiga in sosežiga odpadkov ter proizvodnje cementa se v okolje sproščajo izpusti, ki vsebujejo različna onesnaževala. Z namenom oceniti povezanost med rakom pri poklicno izpostavljenih in okoliških prebivalcih ter izpostavljenostjo okoljskim onesnaževalom iz sežigalnic, naprav za sosežig in cementarn smo si za cilj zadali izdelavo krovnega pregleda literature. Metode: V krovni pregled literature so bile vključene metaanalize in sistematični pregledi literature v angleščini v obdobju od leta 1980 do leta 2023. Iskanje je bilo izvedeno v štirih podatkovnih zbirkah (PubMed, Scopus, Web of Science, Cochrane Reviews). Kakovost je bila ocenjena z orodjema AMSTAR-2 (metodologija) in GRADE (dokazi). Rezultati: Izmed 7.701 opredeljenih dokumentov jih je bilo v končno analizo vključenih 14 (pet metaanaliz, devet sistematičnih pregledov). Obstajajo nizki do zmerni dokazi o povezanosti med sarkomom mehkih tkiv in ne-Hodgkinovim limfomom z izpostavljenostjo dioksinom v okolici sežigalnic I. generacije, česar študije niso dokazale za sežigalnice naslednjih generacij. Zaenkrat ne razpolagamo z dokazi za sosežig. Pri delavcih v cementarnah I. do II. generacije obstaja nekaj zmernih dokazov o povezanosti med incidenco vseh rakov, pljučnega raka, raka ustne votline in žrela, prostate in želodca z izpostavljenostjo šestvalentnemu kromu. Velika večina dokazov je omejenih zaradi mešanih rezultatov, razlik v tehniki vprašanj, heterogenosti in potencialni pristranosti. Zaključek: Obstajajo omejeni dokazi o povezanosti med rakom in izpostavljenostjo onesnaževalom iz sežigalnic I. in cementarn I. do II. generacije. Za oceno morebitne povezanosti med rakom in onesnaževali iz najsodobnejših naprav za sosežig je smiselno načrtovati ciljane epidemiološke študije in študije notranje izpostavljenosti z uporabo humanega biomonitoringa.
Keywords: rak, odpadki, sežig, sosežig, cementarna, onesnaževala
Published in DiRROS: 08.01.2024; Views: 181; Downloads: 68
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