1. Cardiotoxicity of concomitant radiotherapy and trastuzumab for early breast cancerTanja Marinko, Jure Dolenc, Cvetka Bilban-Jakopin, 2014, original scientific article Abstract: Background. Trastuzumab therapy given in combination with one of several chemotherapy regimens is currently considered the standard of care for the treatment of early-stage, human epidermal growth factor receptor-2 (HER2) -positive breast cancer. The treatment with trastuzumab is due to a significant impact on the survival part of the standard adjuvant treatment of patients with HER2-positive breast cancer. Patients treated with postoperative breast or chest wall irradiation receive trastuzumab concomitant with radiotherapy. In a small proportion of patients trastuzumab causes cardiotoxicity. Preclinical findings indicate a radiosensibilizing effect of trastuzumab in breast cancer cells, but it is not yet clear whether it radiosensibilizes cells of healthy tissues too.Conclusions. Special attention is required when left breast or left thoracic wall is irradiated in patient receiving trastuzumab, because long-term effects of the concurrent treatment with trastuzumab and radiotherapy are not yet known. In an era where more patients are surviving a diagnosis of breast cancer, better understanding and earlier detection of therapy-induced cardiac toxicity will be of paramount importance.
Keywords: radiotherapy, cardiotoxicity, trastuzumab, early breast cancer
Published in DiRROS: 11.04.2024; Views: 62; Downloads: 37
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5. Cathepsin L in human meningiomasMiha Trinkaus, Andrej Vranič, Vinko V. Dolenc, Tamara Lah Turnšek, 2003, original scientific article Keywords: meningioma-pathology, cathepsin L, reverse transcriptase, polymerase chain reaction, neoplasm invasiveness
Published in DiRROS: 06.02.2024; Views: 150; Downloads: 37
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6. Raman microspectroscopy of garnets from Sfibulae from the archaeological site Lajh (Slovenia)Saša Kos, Matej Dolenec, Judita Lux, Sabina Dolenec, 2020, original scientific article Abstract: Garnets (19 pieces) of Late Antique S-fibulae from the archaeological site at Lajh-Kranj (Slovenia) were analysed with Raman microspectroscopy to obtain their mineral characteristic, including inclusion assemblage. Most garnets were determined as almandines Type I of pyralspite solid solution series; however, three garnets showed a higher Mg, Mn and Ca contents and were determined as almandines Type II. Most significant Raman bands were determined in the range of 169–173 cm−1 (T(X2+)), 346–352 cm−1 (R(SiO4)), 557–559 cm−1 (ν2), 633–637 cm−1 (ν4), 917–919 cm−1 (ν1), and 1042–1045 cm−1 (ν3). Shifting of certain Raman bands toward higher frequencies was the result of an increase of the Mg content in the garnet composition, which also indicates the presence of pyrope end member in solid garnet solutions. Inclusions of apatite, quartz, mica, magnetite, ilmenite, as well as inclusions with pleochroic or radiation halo and tension fissures (zircon), were found in most of the garnets. Rutile and sillimanite were found only in garnets with the highest pyrope content. Spherical inclusions were also observed in two garnets, which may indicate the presence of melt or gas residues. The determined inclusion assemblage indicates the formation of garnets during medium- to high-grade metamorphism of amphibolite or granulite facies. According to earlier investigations of the garnets from Late Antique jewellery, the investigated garnets are believed to originate from India.
Keywords: garnets, inclusions, Sfibulae, Late Antiquity, provenance, Raman microspectroscopy, XRF spectroscopy
Published in DiRROS: 20.12.2023; Views: 153; Downloads: 134
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7. Heavy metal signature and environmental assessment of nearshore sediments: Port of Koper (Northern Adriatic Sea)Nastja Rogan Šmuc, Matej Dolenec, Sabina Dolenec, Ana Mladenovič, 2018, original scientific article Abstract: Heavy metal abundance and potential environmental risks are reported for surface sediments (n = 21) from the Port of Koper area, Republic of Slovenia. The enrichment factor (EF) indicates minor enrichment in arsenic (As), cadmium (Cd), copper (Cu), molybdenum (Mo), lead (Pb), antimony (Sb), and zinc (Zn), moderately to severely enriched with nickel (Ni). The trace metal chemistries, in the context of sediment quality guidelines (SQG), imply adverse threshold effect concentrations (TEC) and probable effect concentrations (PEC), for Ni only. Sediment sequential leaching experiments demonstrated that the majority of heavy metals were of natural lithogenic origin and low bioavailability. The heavy metals’ potential for “Risk Assessment Code” values exhibited no or low anthropogenic environmental burden, with the exception of Mo.
Keywords: port sediments, heavy metals, chemical speciation, risk assessment, Northem Adriatic Sea
Published in DiRROS: 12.12.2023; Views: 169; Downloads: 92
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