Digitalni repozitorij raziskovalnih organizacij Slovenije

Iskanje po repozitoriju
A+ | A- | Pomoč | SLO | ENG

Iskalni niz: išči po
išči po
išči po
išči po

Možnosti:
  Ponastavi


Iskalni niz: "avtor" (��ustovi�� Hamid) .

1 - 3 / 3
Na začetekNa prejšnjo stran1Na naslednjo stranNa konec
1.
Quantitative imaging biomarkers of immune-related adverse events in immune-checkpoint blockade-treated metastatic melanoma patients : a pilot study
Nežka Hribernik, Daniel T. Huff, Andrej Studen, Katarina Zevnik, Žan Klaneček, Hamid Emamekhoo, Katja Škalič, Robert Jeraj, Martina Reberšek, 2022, izvirni znanstveni članek

Povzetek: Purpose: To develop quantitative molecular imaging biomarkers of immune-related adverse event (irAE) development in malignant melanoma (MM) patients receiving immune-checkpoint inhibitors (ICI) imaged with 18F-FDG PET/CT. Methods: 18F-FDG PET/CT images of 58 MM patients treated with anti-PD-1 or anti-CTLA-4 ICI were retrospectively analyzed for indication of irAE. Three target organs, most commonly affected by irAE, were considered: bowel, lung, and thyroid. Patient charts were reviewed to identify which patients experienced irAE, irAE grade, and time to irAE diagnosis. Target organs were segmented using a convolutional neural network (CNN), and novel quantitative imaging biomarkers - SUV percentiles (SUVX%) of 18F-FDG uptake within the target organs - were correlated with the clinical irAE status. Area under the receiver-operating characteristic curve (AUROC) was used to quantify irAE detection performance. Patients who did not experience irAE were used to establish normal ranges for target organ 18F-FDG uptake. Results: A total of 31% (18/58) patients experienced irAE in the three target organs: bowel (n=6), lung (n=5), and thyroid (n=9). Optimal percentiles for identifying irAE were bowel (SUV95%, AUROC=0.79), lung (SUV95%, AUROC=0.98), and thyroid (SUV75%, AUROC=0.88). Optimal cut-offs for irAE detection were bowel (SUV95%>2.7 g/mL), lung (SUV95%>1.7 g/mL), and thyroid (SUV75%>2.1 g/mL). Normal ranges (95% confidence interval) for the SUV percentiles in patients without irAE were bowel [1.74, 2.86 g/mL], lung [0.73, 1.46 g/mL], and thyroid [0.86, 1.99 g/mL]. Conclusions: Increased 18F-FDG uptake within irAE-affected organs provides predictive information about the development of irAE in MM patients receiving ICI and represents a potential quantitative imaging biomarker for irAE. Some irAE can be detected on 18F-FDG PET/CT well before clinical symptoms appear.
Ključne besede: melanoma, malignant melanoma, immune-checkpoint inhibitors, molecular imaging biomarkers
Objavljeno v DiRROS: 07.09.2022; Ogledov: 483; Prenosov: 145
.pdf Celotno besedilo (9,65 MB)

2.
Soil properties in relation to selective logging in beech and fir forest stands - case study at Bjelašnica mountain
Emira Hukić, Primož Simončič, Hamid Čustović, 2015, objavljeni povzetek znanstvenega prispevka na konferenci

Objavljeno v DiRROS: 03.11.2021; Ogledov: 619; Prenosov: 201
.pdf Celotno besedilo (1,05 MB)

3.
Short-term impacts of harvesting intensity on the upper soil layers in high karst Dinaric fir-beech forests
Emira Hukić, Matjaž Čater, Aleksander Marinšek, Mitja Ferlan, Milan Kobal, Daniel Žlindra, Hamid Čustović, Primož Simončič, 2021, izvirni znanstveni članek

Povzetek: The present study addresses the short-term effects of different harvest intensities under close-to-nature selective management on the upper soil layers in Slovenian and Bosnian Dinaric karst fir-beech forests. The different harvest intensities coincided with the single-tree and irregular shelterwood management, common in the region. The effect of harvesting intensity on the upper soil layers (Ol, Of, Ol and 0%10 cm mineral soil) was investigated by a repeated measurements experiment in Slovenia on 27 research plots in close-to nature managed forests. The properties of the upper layers (concentration of SOC and TN, C/N ratio, weights, BD and SOC stocks) were analyzed twice, before (2011) and after (2014) treatment of 50% and 100% harvest intensity in relation to the total standing growing stock of trees. As a control, we used no-treatment <20% harvesting intensity plots. To extend this experiment, we added three comparable plots from the Bosnian site: one in an old-growth forest with 0% harvest intensity and two in the managed forest with <20% harvest intensity. The results of the assessment of mean differences indicated a significant influence of harvesting intensity on the decrease in SOC, TN concentrations, weights and SOC stocks in the organic layers and the increase in BD and SOC stocks in the 0%10 cm mineral soil. The highest relative decreases in Ol, Of and Oh SOC stocks occurred in 50% (%10 and %38%) and 100% (%16 and %49%) harvest intensities. Negligible relative differences in both organic and 0%10 cm mineral layers were found for the <20% harvest intensity in the region. The change in forest light conditions resulting from differences in canopy openness as a function of applied harvest intensity explained the significant difference in the properties of the upper soil layers. The impact of the short-term losses in SOC stocks, in terms of overall soil productivity, may depend on the regeneration dynamics and melioration methods.
Ključne besede: close-to-nature forest management, harvest intensity, Calcic Cambisol, forest soil, soil organic carbon
Objavljeno v DiRROS: 10.05.2021; Ogledov: 1039; Prenosov: 748
.pdf Celotno besedilo (18,42 MB)
Gradivo ima več datotek! Več...

Iskanje izvedeno v 0.16 sek.
Na vrh