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Validation of the recycled backfill material for the landslide stabilization at a railway line
Karmen Fifer Bizjak, Barbara Likar, 2024, izvirni znanstveni članek

Povzetek: In mountain areas landslides many times endanger safety of transport infrastructures, and these must be stabilized with retaining wall structures. In this paper the validation of a new composite as a backfill material for landslide stabilization with a large scale demo retaining wall is presented. The new composite was made from residues of paper industry, which uses for its production deinking process. New composite was validated with the laboratory tests, construction of small demo sites and at the end with a large demo retaining wall structure with a length of 50 m. It was concluded that the paper sludge ash and the paper sludge are in proportion 70:30, compacted on the optimal water content and maximum dry density, reached sufficient uniaxial compressive and shear strength. However, the composite's hydration processes required the definition of an optimal time between the composite mixing and installation. In 2019, the retaining wall structure from the new composite was successfully built. The large demo structure is an example of the knowledge transfer from the laboratory to the construction site, in which composite and installing technology could be verified.
Ključne besede: landslides, recycled backfill material, paper sludge ash, geotechnical composite, railway line, recycled material, environment
Objavljeno v DiRROS: 26.03.2024; Ogledov: 97; Prenosov: 75
.pdf Celotno besedilo (2,96 MB)
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Uterine perforation - 5-year experience in 3-D image guided gynaecological brachytherapy at Institute of Oncology Ljubljana
Barbara Šegedin, Jasenka Gugić Kevo, Primož Petrič, 2013, izvirni znanstveni članek

Povzetek: Background. Accurate applicator placement is a precondition for the success of gynaecological brachytherapy (BT). Unrecognized uterine perforation can lead to bleeding, infection, high doses to pelvic organs and underdosage of the target volume, resulting in acute morbidity, long-term complications and reduced chance of cure. We aimed to assess the incidence and clinical characteristics of our cases with uterine perforation, review their management and impact on the treatment course. Patinets and methods. In all patients, treated with utero-vaginal image guided BT for gynaecological cancer between January 2006 and December 2011, the CT/MR images with the applicator in place were reviewed. The incidence of uterine perforations was recorded. Clinical factors that may have predisposed to increased risk of perforation were recorded. Management of perforations and their impact on treatment course was assessed. Results. 219 patients (428 applications) were suitable for analysis. Uterine perforation was found in 13 (3.0%) applications in 10 (4.6%) patients. The most frequent perforation site was posterior uterine wall (n = 9), followed by anterior wall (n = 2) and fundus (n = 2). All cases were managed conservatively, without complications. Prophylactic antibiotics were administered in 8 cases. In 4 patients, abdominal and/or transrectal ultrasound (US) guidance was used on subsequent applications for applicator insertion; adequate applicator placement was achieved and treatment completed as planned in all cases. Conclusions. 3D imaging for BT planning enables accurate identification of uterine perforations. The incidence of perforations at our department is one of the lowest reported in the literature. US guidance of applicator insertion is useful and feasible, allowing to complete the planned treatment even in challenging cases.
Ključne besede: uterine perforation, brachytherapy, 3D imaging, ultrasound guidance
Objavljeno v DiRROS: 22.03.2024; Ogledov: 68; Prenosov: 26
.pdf Celotno besedilo (367,57 KB)

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The correlation between the levels of tissue inhibitor of metalloproteinases 1 in plasma and tumour response and survival after preoperattive radiochemotherapy in patients with rectal cancer
Irena Oblak, Vaneja Velenik, Franc Anderluh, Barbara Možina, Janja Ocvirk, 2013, izvirni znanstveni članek

Povzetek: Background. The aim of this study was to analyse whether the level of tissue inhibitor of metalloproteinases (TIMP) 1 is associated with the tumour response and survival to preoperative radiochemotherapy in rectal cancer patients. Patients and methods. Ninety-two patients with histologically confirmed non-metastatic rectal cancer of clinical stage I- III were treated with preoperative radiochemotherapy, surgery and postoperative chemotherapy. Plasma TIMP-1 concentrations were measured prior to the start of the treatment with an enzyme-linked immunosorbent assay (ELISA). Results. Median follow-up time was 68 months (range: 3-93 months) while in survivors it was 80 months (range: 68-93 months). The 5-year locoregional control (LRC), disease-free survival (DFS), disease-specific survival (DSS) and overall survival (OS) rates for all patients were 80.2%, 56.4%, 63.7% and 52.2%, respectively. The median TIMP-1 level was 185 ng/mL (range: 22-523 ng/mL) and the mean level (standard deviation) was 192 (87) ng/mL. Serum TIMP-1 levels were found to be significantly increased in patients with preoperative CRP>12 mg/L and in those who died from rectal cancer or had cT4 tumours. No correlation was established for age, gender, carcinoembriogenic antigene (CEA) level, platelets count, histopathological grade, response to preoperative therapy, resectability and disease reappearance. On univariate analysis, various parameters favourably influenced one or more survival endpoints: TIMP-1 <170 ng/mL, CRP <12 mg/L, platelets count <290 10E9/L, CEA <3.4mg/L, age <69 years, male gender, early stage disease (cN0 and/or cT2-3), radical surgery (R0) and response to preoperative radiochemotherapy. In multivariate model, LRC was favourably influenced by N-downstage, DFS by lower CRP and N-downstage, DSS by lower CRP and N-downstage and OS by lower TIMP-1 level, lower CRP and N-downstage. Conclusions. Although we did not find any association between pretreatment serum TIMP-1 levels and primary tumour response to preoperative radiochemotherapy in our cohort of patients with rectal cancer, TIMP-1 levels were recognized as an independent prognostic factor for OS in these patients.
Ključne besede: rectal cancer, radiochemotherapy, tissue inhibitor of metalloproteinases
Objavljeno v DiRROS: 22.03.2024; Ogledov: 83; Prenosov: 25
.pdf Celotno besedilo (370,87 KB)

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