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71.
Priporočila Onkološkega inštituta za zdravljenje bolnikov z adenokarcinomom želodca
2021, druge monografije in druga zaključena dela

Povzetek: V Sloveniji vsako leto zboli zaradi raka želodca okrog 450 bolnikov, od tega ima tri četrtine bolnikov ob postavitvi diagnoze razširjeno ali razsejano bolezen. Zato je pomembno, da imamo razvito sodobno multidisciplinarno zdravljenje. Onkološki inštitut je na poti pridobitve evropske onkološke akreditacije, ki jo podeljuje priznana Evropska organizacija onkoloških inštitutov (OECI), katere član je tudi Onkološki inštitut Ljubljana. Namen tega projekta je razvoj kliničnih poti, ki bodo omogočile celostno obravnavo bolnikov z rakom. Slovenskih priporočil za zdravljenje adenokarcinoma želodca trenutno nimamo, zato smo bili primorani sprejeti te, ki jim bomo sledili na Onkološkem inštitutu. V teh priporočilih, zaradi drugačne narave bolezni, ni zajeto zdravljenje raka ezofagogastričnega stika.
Ključne besede: rak želodca, adenokarcinom, onkološko zdravljenje, priporočila
Objavljeno v DiRROS: 14.09.2021; Ogledov: 1361; Prenosov: 362
.pdf Celotno besedilo (983,68 KB)

72.
Climatic regulation of leaf and cambial phenology in Quercus pubescens : their interlinkage and impact on xylem and phloem conduits
Jožica Gričar, Jernej Jevšenak, Polona Hafner, Peter Prislan, Mitja Ferlan, Martina Lavrič, Dominik Vodnik, Klemen Eler, 2022, izvirni znanstveni članek

Povzetek: Increased frequency and severity of stressful events affects the growth patterns and functioning of trees which adjust their phenology to given conditions. Here, we analysed environmental effects (temperature, precipitation, VPD and SWC) on the timing of leaf phenology, seasonal stem radial growth patterns, and xylem and phloem anatomy of Quercus pubescens in the sub-Mediterranean in the period 2014%2019, when various adverse weather events occurred, i.e. spring drought in 2015, summer fire in 2016 and summer drought in 2017. Results showed that the timings of leaf and cambium phenology do not occur simultaneously in Q. pubescens, reflecting different environmental and internal constraints. Although year-to-year variability in the timings of leaf and cambial phenology exists, their chronological sequence is fairly fixed. Different effects of weather conditions on different stages of leaf development in spring were observed. Common climatic drivers (i.e., negative effect of hot and dry summers and a positive effect of increasing moisture availability in winter and summer) were found to affect the widths of xylem and phloem increments with more pronounced effect on late formed parts. A legacy effect of the timing of leaf and cambial phenology of the previous growing season on the timing of phenology of the following spring was confirmed. Rarely available phloem data permitted a comprehensive insight into the interlinkage of the timing of cambium and leaf phenology and adjustment strategies of vascular tissues in Mediterranean pubescent oak to various environmental constraints, including frequent extreme events (drought, fire). Our results suggest that predicted changes in autumn/winter and spring climatic conditions for this area could affect the timings of leaf and stem cambial phenology of Q. pubescens in the coming years, which would affect stem xylem and phloem structure and hydraulic properties, and ultimately its performance.
Ključne besede: pubescent oak, leaf development, radial growth, initial earlywood vessel, sieve tube, anatomy, cambial cell production, extreme weather events
Objavljeno v DiRROS: 06.09.2021; Ogledov: 932; Prenosov: 265
.pdf Celotno besedilo (7,00 MB)
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75.
Rak debelega črevesa in danke : kaj morate vedeti o bolezni
Janja Ocvirk, Vaneja Velenik, Franc Anderluh, Maja Ebert Moltara, Ibrahim Edhemović, Zvezdana Hlebanja, Irena Oblak, Martina Reberšek, 2013, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid

Ključne besede: rak debelega črevesa, rak danke, zdravljenje, bolniki, priročniki
Objavljeno v DiRROS: 19.03.2021; Ogledov: 1065; Prenosov: 375
.pdf Celotno besedilo (2,31 MB)

76.
Imunoterapija v onkologiji
2017, druge monografije in druga zaključena dela

Ključne besede: imunoterapija, imunski sistem, novotvorbe, neoplazme, zborniki
Objavljeno v DiRROS: 18.03.2021; Ogledov: 953; Prenosov: 339
.pdf Celotno besedilo (16,32 MB)

77.
Development of novel 3D in vitro cell models for genotoxicity assessment : doctoral dissertation
Martina Štampar, 2021, doktorska disertacija

Objavljeno v DiRROS: 17.02.2021; Ogledov: 1906; Prenosov: 506
.pdf Celotno besedilo (43,12 MB)

78.
PD-L1 expression can be regarded as prognostic factor for survival of non-small cell lung cancer patients after chemoradiotherapy
Martina Vrankar, Matjaž Zwitter, Izidor Kern, Karmen Stanič, 2018, izvirni znanstveni članek

Povzetek: The standard treatment for inoperable locally advanced non-small cell lung cancer (LA NSCLC) includes concurrent or sequential chemotherapy (ChT) and radiation therapy (RT). Long term survival rates with these approaches remains only in the order of 15%, therefore new treatment strategies, including immunotherapy, are under investigation, with programmed death ligand-1 (PD-L1) as one of the major players. We evaluated the clinical significance of PD-L1 expression in tumor samples from patients with inoperable LA NSCLC who underwent concurrent chemoradiotherapy (CRT) in our institution between 2005 and 2010 and correlated their expression with clinicopathological parameters and outcome of treatment. Among 107 patients treated with concurrent CRT, a total of 43 (36 males and 7 females) had sufficient tissue for immunohistochemical (IHC) staining. The expression of PD-L1 was demonstrated in 7 tumors, in 6 males and 1 female. No statistical significant differences in patient characteristics, including age, smoking status and gender, were found according to the PD-L1 expression. After a median follow up of 103.6 months, median progression free survival (PFS) was 19.9 months in patients without and 10.1 months in patients with PD-L1 expression (p=0.008). Median overall survival (OS) was 28.4 and 12.1 months for PD-L1 negative and PD-L1 positive patients, respectively (p=0.012). In conclusions, patients with PD-L1 expression had shorter PFS and OS after concurrent CRT in LA NSCLC. Unfortunately, only small number of patients had tissue available for the IHC testing, therefore no firm conclusions could be made and further investigation is warranted.
Ključne besede: non-small cell lung cancer, lung cancer, chemoradiotherapy, survival
Objavljeno v DiRROS: 17.12.2020; Ogledov: 1310; Prenosov: 413
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79.
10. šola tumorjev prebavil, 12.-13. november 2020, Ljubljana
2020, druge monografije in druga zaključena dela

Ključne besede: tumorji prebavil, rak prebavil, zdravljenje, zborniki
Objavljeno v DiRROS: 07.12.2020; Ogledov: 1282; Prenosov: 438
.pdf Celotno besedilo (36,64 MB)

80.
Substituted 4,5'-bithiazoles as catalytic inhibitors of human DNA topoisomerase II [alpha]
Kaja Bergant Loboda, Matej Janežič, Martina Štampar, Bojana Žegura, Metka Filipič, Andrej Perdih, 2020, izvirni znanstveni članek

Objavljeno v DiRROS: 25.11.2020; Ogledov: 1269; Prenosov: 790
.pdf Celotno besedilo (8,27 MB)
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