11. Legislation on the protection of experimental animalsDragica Ornik, Milan Pogačnik, 2001, review article Abstract: The aim of this paper is to establish the current situation in the field of legislation on the protection of experimental animals in Slovenia. The protection of experimental animals has been regulated by the provisions of theProtection of Animals Act.1 On the basis of this act, the Instructions on Conditions for the Issuing of Authorisations for Experiments on Animals for Scientific and Research Purposes2 and the Rules on the Ethics Commission for Experiments on Animals 3 have been used. The basic protection of experimental animals is provided for by a system of permits for experiments on animals. Permits for experiments on animals are granted by the administrative authorities responsible for veterinary medicine in cases where experiments areurgently required for medical, veterinary medical, or scientific and research purposes and the results are expected to produce important new knowledge, or when the suffering of animals is ethically acceptable in comparison with what the experiment is expected to achieve; where, in cases ofbasic research, experimental aims cannot be achieved by any other method or procedure, the experiment is performed on the minimum possible number of animals of the lowest neurophysiological sensitivity and a method is used thatcauses the minimum level of suffering, pain or lasting harm. Staff involved in the execution of experiments or in the care and nursing of animals, the premises for the accommodation or rearing and provision of animals, and the installations and devices used must all comply with the set conditions. (Abstract truncated at 2000 characters) Published in DiRROS: 26.01.2024; Views: 132; Downloads: 34 Full text (71,46 KB) |
12. Persistent chromosomal aberrations in somatic cells in testicular cancer patients after different therapiesCvetka Bilban-Jakopin, Marjan Bilban, 2001, original scientific article Abstract: Background. The damage due to radiation or chemotherapeutic agents has been estimated successfully for the last 35 years from the numbers of the chromosome changes. This finding may serve as biological dosimeter. The aim ofthe study was to find persistent chromosomal aberrations in somatic cells intesticular cancer patients after different therapies. Patients and methods. This prospective study includes 60 patients with testicular tumours. With respect to the histological results and various therapies that they were giventhey were divided into four groups. Prior to treatment, we did not detectany deviations either in the genome picture of our patients or in that of the subjects of the control group without malignant disease. The changes inthe genome of individual cells after therapy were detected by the following tests: structural chromosomal aberrations (SCA) test, sister chromatid exchange (SCE) test and micronucleus (MN) test performed on binuclear lymphocytes. (Abstract truncated at 2000 characters) Published in DiRROS: 26.01.2024; Views: 128; Downloads: 28 Full text (169,51 KB) |
13. |
14. Cytology of mediastinal tumorsMilivoj Mermolja, Izidor Kern, Marjeta Terčelj-Zorman, Marjan Jereb, 1997, original scientific article Abstract: Our experience with cytological examinations of tumorous mediastinal lesions is evaluated. A group of 117 patients with mediastinal tumor have been included into the study. Among them carcinomas prevailed (60,7%), followed by lymphomas (18,8%), other tumors (15.4%) and thymic neoplasms (5.1%). Malignantor suspicious cells were found in 77.4% of patients with carcinoma. The cells indicating a possibility of non-Hodgkin's lymphoma were found in 9 out of 14 patients. In 5 out of 6 thymic neoplasms the cytological pattern wasconsistent with the diagnosis of thymic neoplasm. One case of thymoma was cytologically falsely diagnosed as malignant lymphoma. One case of neurofibroma was falsely diagnosed as adenocarcinoma. The sensitivity of cytological examinations was 67.5%. If 18 patients with diagnostically unsatisfactory material were excluded from the analysis, the sensitivity wouldincrease to 80.8%. Owing to the wide variety of primary and metastatic tumors that can occur in the mediastinum, apart from the routine cytological techniques, additional staining methods should be used. For final cytological diagnosis the integration of cytological findings with clinical and radiological data is often required. Owing to the characteristics of the obtained material and biological behaviour of some mediastinal tumors, some tumors cannot be definitively diagnosed by cytological examinations alone. Published in DiRROS: 18.01.2024; Views: 162; Downloads: 43 Full text (1,10 MB) |
15. |
16. |
17. |
18. |
19. Austrofoma 2023Marjan Dolenšek, Peter Smolnikar, Martin Jež, Amina Gačo, Urban Žitko, Vasja Kavčič, Matjaž Dovečar, 2023, professional article Keywords: traktorji, gozdarska mehanizacija, sejmi, strojna sečnja, transport lesa Published in DiRROS: 12.01.2024; Views: 226; Downloads: 62 Full text (11,50 MB) |
20. |