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41.
Molecular alterations induced in drug-resistant cells
Maja Osmak, 1998, original scientific article

Abstract: The major obstacle to the ultimate success in cancer therapy is the ability oftumor cells to develop resistance to anticancer drugs. Several molecular mechanisms have been suggested to be involved in drugresistance: a) decrease in the intracellular drug accumulation (increased activity of membrane transporters such as P-glycoprotein or multidrug-resistance-associated protein), b) changes in intracellular detoxification system (increased concentrations of glutathione or metallothioneins, or increased activity of related enzymed), c) alteration in nuclear enzymes (enhanced DNA repair and/orbetter tolerance of DNA damage, decreased acitivty of topoisomerases), d) altered expression of oncogenes (inducing increased level of protective molecules in cells or the inhibition of apoptosis). Drug resistance is a multifactorial phenomenon. The complexity of molecular alterations in drug-resistant cells is and will stay the main problem for the successful treatment of cancer.
Published in DiRROS: 19.01.2024; Views: 135; Downloads: 25
.pdf Full text (2,17 MB)

42.
Znanje, ki pušča sled : sedemdeset let Zavoda za gradbeništvo Slovenije 1949-2019
2019, professional monograph

Abstract: V publikaciji je predstavljen Zavod za gradbeništvo Slovenije, ob 70-letnici. V osmih poglavjih je predstavljeno znanstveno-raziskovalno in strokovno delo. V nadaljevanju sledijo poglavja, ki predstavljajo posamezne zanszveno-raziskovalne laboratorije in strokovne službe.
Keywords: Zavod za gradbeništvo Slovenije, ZAG Ljubljana, gradbeništvo, znanstveno-raziskovalna dejavnost, strokovna dejavnost, laboratoriji, predstavitev, 70 let, sedemdeset let, grajeno okolje, digitalizacija, gradnja, les, krožno gospodarstvo, napredni materiali v gradbeništvu, potresi, stavbe, trajnostna gradnja, bivanje, ekologija, voda, zrak, zemlja
Published in DiRROS: 19.01.2024; Views: 157; Downloads: 112
.pdf Full text (19,25 MB)
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43.
Knowledge that leaves a mark : seventy years of the Slovenian National Building and Civil Engineering Institute 1949-2019
2019, professional monograph

Abstract: V publikaciji je predstavljen Zavod za gradbeništvo Slovenije ob 70-letnici. V osmih poglavjih je predstavljeno znanstveno-raziskovalno in strokovno delo. V nadaljevanju sledijo poglavja, ki predstavljajo posamezne znanstveno-raziskovalne laboratorije in strokovne službe.
Keywords: Zavod za gradbeništvo Slovenije, ZAG Ljubljana, gradbeništvo, znanstveno-raziskovalna dejavnost, strokovna dejavnost, laboratoriji, predstavitev, 70 let, sedemdeset let, grajeno okolje, digitalizacija, gradnja, les, krožno gospodarstvo, napredni materiali v gradbeništvu, potresi, stavbe, trajnostna gradnja, bivanje, ekologija, voda, zrak, zemlja
Published in DiRROS: 19.01.2024; Views: 151; Downloads: 102
.pdf Full text (19,17 MB)
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44.
In vivo electroporation of the urinary bladder in mice
Peter Veranič, Kristijan Jezernik, Maja Čemažar, Gregor Serša, 1998, original scientific article

Published in DiRROS: 19.01.2024; Views: 128; Downloads: 36
.pdf Full text (556,60 KB)

45.
Vinblastine increases antitumor effectiveness of bleomycin
Maja Čemažar, Marija Auersperg, Gregor Serša, 1997, original scientific article

Abstract: In our previous vinblastine (VELBE) was shown to increase the plasma membrane fluidity. This effect of VELBE might be expolited for better transport of drugs through the plasma membrane. Bleomycin (BLM) is a highly cytotoxic drug when present inside the cells but has a hampered transport through the plasma membrane. The aim of the present study was to determine whether pretreatment with VELBE can increase the effect of BLM on intraperitoneal SA-1 tumors in mice. BLM and VELBE were used as single agents or in various combinations, i.e. VELBE and BLM injected simultanously, BLM injected 24 h before VELBE or VELBE injected 24 h before BLM. Mice survival was the end-point used for determining the effect of this combined treatments. VELBE and BLM as a single treatment significantly prolonged median survival time of study animals compared to controls. Furthermore, when VELBE and BLM were combined, all threetested combinations were more effective than VELBE or BLM as single treatments. The effect on animal survival was equal when VELBE was given 24 h after or simultanously with BLM. The longest survival, however was obtained when VELBE was injected 24 h before BLM. From these results we can conclude that the underlying mechanisms for more than additive effect of VELBE and BLM when VELBE was given 24 h before BLM could be attributed to an increased membrane fluidity, possibly in combination with a cell kinetic effect.
Published in DiRROS: 18.01.2024; Views: 114; Downloads: 25
.pdf Full text (1,28 MB)

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47.
European code against cancer
P... Boyle, Maja Primic-Žakelj, 1995, popular article

Published in DiRROS: 15.01.2024; Views: 140; Downloads: 40
.pdf Full text (94,96 KB)

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50.
European code against cancer
Peter Boyle, Maja Primic-Žakelj, 1995, not set

Keywords: rak (medicina), preventiva, Evropa
Published in DiRROS: 15.01.2024; Views: 154; Downloads: 52
.pdf Full text (94,96 KB)

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