Iskanje po repozitoriju

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Povzetek: V prispevku so opisana specialna slikanja, ki jih uporabljamo pri mamografijah. Mednje sodijo: cleavage, tangencialna projekcija, slikanje vsadkov in moške dojke. Z natančno tehnično izvedbo teh preiskav marsikdaj lahko rešimo nadaljno diagnostiko in operativno obdelavo.
Objavljeno v DiRROS: 30.11.2023; Ogledov: 228; Prenosov: 60
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Povzetek: Rak materničnega telesa je heterogena bolezen, najpogostejši histološki endometroidni podtip ima najpogosteje izražene hormonske receptorje. V trenutni molekularni klasifikaciji se je izraženost estrogenskih (ER+) in progesteronskih receptorjev (PR+) izkazala kot prognostični dejavnik. Izraženost hormonskih receptorjev dodatno opredeli rak materničnega telesa, ki je brez specifičnega molekularnega profila. Pri zgodnjem raku materničnega telesa je pri endometroidnem podtipu, gradusa 1 do 2, FIGO 1A, možna konzervativna terapijas progestini, zadnja metaanaliza je pokazala manjšo verjetnost recidiva ob dodatku metformina. Pri napredovalem raku materničnega telesa, endometroidni gradusa 1 ali 2, ki je tipično hormonsko odvisen prihaja v poštev hormonska terapija, če ni velikega bremena bolezni. Raziskani so bili progestini, aromatazni inhibitorji, tamoksifen in fulvestrant. Predstavljen je tudi vpogled eventuelnih zdravljenj v prihodnosti glede na faze II raziskav, nakazuje se, da v prihodnosti lahko boljše odgovore na zdravljenje in/ali preživetje brez napredovanja bolezni, če aromataznim inhibitorjem dodamo CDK4/6 inhibitorje in/ali mTOR inhibitorje.
Ključne besede: rak maternice, ginekološki raki, ginekološka onkologija
Objavljeno v DiRROS: 30.05.2023; Ogledov: 287; Prenosov: 110
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Povzetek: The COVID-19 pandemic profoundly changed everyday life of social actors, which inferred mental health and well-being concerns. As students of health-related studies tend to adapt better to difficult circumstances, in this study, we explored the effect of the pandemic on sports science students’ well-being during the summer of 2022. The research was conducted in Slovenia and Serbia. The sample comprised n = 350 students. The PERMA-Profiler, a 15-item self-reported questionnaire, was adapted to assess well-being across five elements: positive emotions, engagement, relationships, meaning, and accomplishment. Data were collected with a questionnaire through the summer of 2022 (from May to July) and analyzed in SPSS, AMOS 26.0. The results revealed normal functioning (M = 7.72, SD ± 1.38) for the overall well-being of the students. Although all dimensions indicated high scores, relationships (M = 7.95, SD ± 1.63), meaning (M = 7.76, SD ± 1.69), and engagement (M = 7.73, SD ± 1.36) rated the highest. Furthermore, the instrument was acceptable, as the confirmatory factor analysis showed adequate reliability based on Cronbach's alpha (15 items, α = 0.94) and strong internal correlations between the PERMA dimensions. This study contributes to the previously published research, emphasizing the positive responses and successful coping of sports science students in times of complex situations, such as the COVID-19 pandemic.
Ključne besede: sport, health science, physical education, university students, pandemics, mental health, well-being
Objavljeno v DiRROS: 16.02.2023; Ogledov: 393; Prenosov: 217
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Povzetek: Detection of germline and somatic pathogenic/likely pathogenic variants (PV/LPV) in BRCA genes is at the moment a prerequisite for use of PARP inhibitors in different treatment settings of different tumors. The aim of our study was to determine the most appropriate testing workflow in epithelial ovarian cancer (EOC) patients using germline and tumor genotyping of BRCA and other hereditary breast and/or ovarian cancer (HBOC) susceptibility genes. Consecutive patients with advanced non-mucinous EOC, who responded to platinum-based chemotherapy, were included in the study. DNA extracted from blood and FFPE tumor tissue were genotyped using NGS panels TruSightCancer/Hereditary and TruSight Tumor 170. Among 170 EOC patients, 21.8% had BRCA germline or somatic PV/LPV, and additionally 6.4% had PV/LPV in other HBOC genes. Sensitivity of tumor genotyping for detection of germline PV/LPV was 96.2% for BRCA genes and 93.3% for HBOC genes. With germline genotyping-only strategy, 58.8% of HBOC PV/LPV and 68.4% of BRCA PV/LPV were detected. By tumor genotyping-only strategy, 96.1% of HBOC PV/LPV and 97.4% of BRCA PV/LPV were detected. Genotyping of tumor first, followed by germline genotyping seems to be a reasonable approach for detection of PV/LPV in breast and/or ovarian cancer susceptibility genes in non-mucinous EOC patients.
Ključne besede: BRCA, ovarian cancer, tumor genotyping, HBOC
Objavljeno v DiRROS: 06.09.2022; Ogledov: 509; Prenosov: 277
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Povzetek: Legislation addressing the quality of groundwater and increasing concerns over public health calls for the development of analytical methods that can produce accurate and precise results at the ppt level. Passive sampling has been recognised as a helpful tool in identifying various organic pollutants in groundwater, even when their presence had not yet been identified through conventional groundwater quality monitoring. The article presents an analytical method involving a simple and cost-effective passive sampling device using Zorflex® activated carbon fibres (ACFs) for the qualitative monitoring of a broad range of organic pollutants in water in a single run. The applicability of the method developed was tested in three hydrogeological studies. In the first case, we present a non-targeted qualitative screening and a list of 892 different contaminants detected in the groundwater in Slovenia. In the second case, we discuss the presence and origin of organic compounds in the groundwater from a pilot area of the urban aquifer, Ljubljansko polje. The third case presents a comparison of results between passive and grab sampling. Passive sampling with ACFs confirmed the presence of a pollutant, even when it had not been previously detected through a quantitative method.
Ključne besede: GC-MS, organic pollutants, qualitative analysis, passive sampling, groundwater
Objavljeno v DiRROS: 03.03.2022; Ogledov: 688; Prenosov: 293
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