1. Contaminant trends in urban groundwater: case study from Ljubljana (central Slovenia)Janja Svetina, Joerg Prestor, Brigita Jamnik, Primož Auersperger, Mihael Brenčič, 2024, izvirni znanstveni članek Povzetek: Urban areas can significantly alter the quality status of aquifers if appropriate strategies to prevent and detect groundwater contamination are not implemented in time. The prevention of groundwater contamination should be a priority due to its potential long-term impact on the environment and the high cost of remediation. For effective and sustainable groundwater management, it is crucial to proactively monitor a wide range of compounds to prevent their spread, progression and increasing concentrations. This study is one of the few to analyse the trends of various urban groundwater contaminants (nitrate, sulphate, hexavalent chromium, pesticides, PCE and TCE) from a groundwater management perspective. Characteristic trends are assessed using linear regression and the Mann–Kendall method, while significant changes in trends are determined using the Darken and Pettitt tests. The time span of the analysed trends covers the transition period before and after the implementation of the Water Framework Directive (2000/60/EC) and the Groundwater Directive (2000/60/EC). This study confirms the effectiveness of enforcement measures to protect groundwater quality, as evidenced by several statistically significant decreasing trends. On the other hand, this study emphasises the importance of intervention-targeted sampling campaigns and the reporting of raw analytical values according to the ISO 11843 series of standards. This approach is essential to detect upward trends in emerging contaminants at an early stage and prevent them from reaching levels that could negatively impact the economy or even jeopardise the safety of drinking water supplies. Ključne besede: groundwater contamination, contaminant trends, groundwater management, urban aquifer, Ljubljansko polje Objavljeno v DiRROS: 25.03.2024; Ogledov: 90; Prenosov: 31 Celotno besedilo (7,36 MB) |
2. The diffuse large B-cell lymphoma - where do we stand now in everyday clinical practiceBrigita Gregorič, Vesna Zadnik, Barbara Jezeršek Novaković, 2012, izvirni znanstveni članek Povzetek: Background. Due to superior results observed with the addition of rituximab into treatment of patients with the diffuse large B-cell lymphoma (DLBCL),the R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) regimen and its variants became the standard initial treatment of these patients. However, the treatment recommendations are based on resultsof clinical studies while the conditions of routine treatment are far different from the ones in clinical studies. The aim of this retrospective study was therefore to compare the treatment results of routinelz treated patients with the DLBCL to results reported by some larger studies. Patients and methods. Two hundred and ninety five patients with the DLBCL were treated between 2004 and 2008 according to the then protocol with R-CHOP or R-CHOP-like regimens at the Institute of Oncology Ljubljana. Treatment response was evaluated according to Chesonʼs criteria and the disease-free andoverall survival by means of Kaplan Meier survival curves. Results. Response to treatment in our evaluation diverged from the reported one predominately in the low risk group (international prognostic index [IPI] categorisation) and in the very good prognosis group (revised international prognostic index (R-IPI) categorisation). The determined complete response (CR) rates in other IPI and R-IPI groups were generally within expectations. Also in the disease-free survival the largest discrepancy occurred in the low-risk patient group (3 year disease-free survival rate of 75%) and in the very good prognosis group (4 year disease-free survival rate of 59%). In all other IPI risk groups, the disease-free survival at 3 zears (low intermediate risk 76%, high intermediate risk group 57%, and high risk group 53%) agreed verz well with the quoted ones. Slightly worse was the compliance of the 4 year disease-free survival rates (72% in the good prognosis and 51% in the poor prognosis group) with the results from the literature. The 3 year overall survival rates (low risk patients 87%, high intermediate risk 61% and high risk patients 51%) were somewhat worse than the reported ones in all IPI subgroups except in the low intermediate risk group (82%). On the other hand, the 4 year overall survival rates of the R-IPI categories (94% in the very good prognosis group, 80% in the good prognosis group, 56% in the poor prognosis group) were much better correlated with the data from the literature. Conclusions. In total, the treatment outcomes of routinely treatedpatient with the DLBCL at our institute are quite encouraging when compared to results of some larger studies. There are probably no dilemmas about how to treat young good prognosis patients and patients aged over 60 years at present. However, the 5 year overall survival rate of 76% for the young poor prognosis group is unsatisfying and needs to be improved. At present, quite a few studies are underway to clarify which of the regimens will perform best in this population. Ključne besede: diffuse large B-cell lymphoma, R-CHOP, treatment result, routine treatments Objavljeno v DiRROS: 21.03.2024; Ogledov: 78; Prenosov: 29 Celotno besedilo (621,34 KB) |
3. Qualitative analysis of the minimal Higgins model of glycolysisBrigita Ferčec, Matej Mencinger, Tatjana Petek, Orhan Ozgur Aybar, Ilknur Kusbeyzi Aybar, 2023, izvirni znanstveni članek Povzetek: Glycolysis, one of the leading metabolic pathways, involves many
different periodic oscillations emerging at positive steady states of
the biochemical models describing this essential process. One of
the models employing the molecular diffusion of intermediates is
the Higgins biochemical model to explain sustained oscillations. In
this paper, we investigate the center-focus problem for the minimal
Higgins model for general values of the model parameters with the
help of computational algebra. We demonstrate that the model
always has a stable focus point by finding a general form of the first
Lyapunov number. Then, varying two of the model parameters, we
obtain the first three coefficients of the period function for the stable focus point of the model and prove that the singular point is actually a bi-weak monodromic equilibrium point of type $[1, 2]$. Additionally, we prove that there are two (small) intervals for a chosen parameter $a > 0$ for which one critical period bifurcates from this singular point after small perturbations. Ključne besede: biological processes, biochemical models, glycolysis Objavljeno v DiRROS: 18.03.2024; Ogledov: 79; Prenosov: 41 Celotno besedilo (837,28 KB) Gradivo ima več datotek! Več... |
4. Pitna voda v Mestni občini Ljubljana : pot od vodnega vira do kozarcaTadeja Kosec, Nina Gartner, Brigita Jamnik, Viviana Golja, Alenka Labovič, Lucija Smojver, Sabina Dolenec, Aljoša Šajna, Monika Novak Babič, Nina Gunde-Cimerman, Tinkara Kopar, 2019, strokovna monografija Ključne besede: centralni vodovodni sistem Ljubljana (CVS), pitna voda, materiali v stiku s pitno vodo, vzdrževanje sistemov, preskušanje, kovinski materiali, organski materiali, cementni materiali, mikrobiološki vpliv, certificiranje proizvodov, vodno gospodarstvo, oskrba z vodo Objavljeno v DiRROS: 08.03.2024; Ogledov: 101; Prenosov: 47 Celotno besedilo (4,02 MB) Gradivo ima več datotek! Več... |
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6. Biorefining twin transition : digitalisation for bio-based chemicals/materials - discovery, design and optimisationMatej Žula, Miha Grilc, Andrii Kostyniuk, Giorgio Tofani, Edita Jasiukaityte, Tina Ročnik, Ramesh Kumar Chowdari, Žan Lavrič, Janvit Teržan, Brigita Hočevar, Ana Jakob, Emilija Rakić, Brett Pomeroy, Miša Mojca Cajnko, Filipa A. Vicente, Dana Marinič, Ana Oberlintner, Uroš Novak, Davide Benedetto Tiz, Matej Huš, Blaž Likozar, 2023, izvirni znanstveni članek Objavljeno v DiRROS: 10.01.2024; Ogledov: 161; Prenosov: 73 Celotno besedilo (917,66 KB) Gradivo ima več datotek! Več... |
7. Selective demethylation reactions of biomass-derived aromatic ether polymers for bio-based lignin chemicalsFlorian Maximilian Harth, Brigita Hočevar, Tina Ročnik, Edita Jasiukaityte, Jana Blüm, Michael Fiedel, Blaž Likozar, Miha Grilc, 2023, pregledni znanstveni članek Objavljeno v DiRROS: 18.12.2023; Ogledov: 214; Prenosov: 81 Celotno besedilo (2,29 MB) Gradivo ima več datotek! Več... |
8. Bolečina pri mamografijiZvonko Krajnc, Brigita Hudales, Andreja Kokot, Kristijana Hertl, Maksimiljan Kadivec, Elizabeta Jokan, 2004, objavljeni znanstveni prispevek na konferenci Povzetek: Izhodišča. Bolečina pri mamografiji je neprijetrna čutnaa in čustvena izkušnja, povezana z dejansko ali možno okvaro tkiva. Nanjo vplivajo različni dejavniki. Metode. Pri preiskovankah, ki so na Onkološkem inštitutu in po vsejSloveniji opravile mamografijo, smo naredili anketno raziskavo o bolečini pri tej preiskavi. Rezultati. Asimptomatske preiskovanke občutijo manjšo jakost bolečine kot simptomatske. `lečina preiskovank v Sloveniji ne zaužije premedikacije pred mamografijo. Zaključki. Informiranje preiskovank o poteku preiskave in vnaprejšne pričakovanje bolečine je pomembno pri zmanjševanju bolečine. velik vpliv na občutenje bolečine ima tudi radiološki inženir, ki jepo mnenju preiskovank pomembno vplival na zmanjševanje bolečine pri mamografiji. Objavljeno v DiRROS: 01.12.2023; Ogledov: 176; Prenosov: 56 Celotno besedilo (746,54 KB) |
9. Ciljana kompresija in povečavaPatricija Špeh, Andreja Kokot, Brigita Hudales, 2001, objavljeni strokovni prispevek na konferenci Povzetek: Ciljano kompresijo in povečavo uporabljamo, kadar želimo razjasniti sumljive nepravilnosti, ki so vidne na osnovnih mamogramih. Ciljana kompresija nam omogoči razmik tkiva, medtem ko povečavo največkrat uporabljamo za boljši prikaz mikrokalcinacij. Včasih pa obe kombiniramo. Objavljeno v DiRROS: 30.11.2023; Ogledov: 179; Prenosov: 47 Celotno besedilo (516,10 KB) |
10. Dodatne projekcije (cleveage, tangencialna projekcija, slikanje vsadkov, moška dojka)Andreja Kokot, Brigita Hudales, Patricija Špeh, 2001, objavljeni strokovni prispevek na konferenci Povzetek: V prispevku so opisana specialna slikanja, ki jih uporabljamo pri mamografijah. Mednje sodijo: cleavage, tangencialna projekcija, slikanje vsadkov in moške dojke. Z natančno tehnično izvedbo teh preiskav marsikdaj lahko rešimo nadaljno diagnostiko in operativno obdelavo. Objavljeno v DiRROS: 30.11.2023; Ogledov: 223; Prenosov: 59 Celotno besedilo (824,11 KB) |