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The influence of different fibres quantity on mechanical and microstructural properties of alkali-activated foams
Katja Traven, Mark Češnovar, Barbara Horvat, Vilma Ducman, 2022, objavljeni znanstveni prispevek na konferenci

Povzetek: Alkali activated foams (AAFs) were produced using electric arc furnace steel slag (EAF) and ladle furnace basic slag (LS), obtained from two metallurgical companies in Slovenia. They were activated with a mixture of sodium water glass (Na2SiO3) and solid NaOH and foamed with hydrogen peroxide (H2O2). Pores were stabilized with the addition of Triton as a surfactant. Four types of fibres were added to the studied mixture (polypropylene (PP), polyvinyl-alcohol (PVA), basalt (B), and glass wool (GW)) in five different quantities: 0.5, 1.0, 1.25, 1.5 and 2.0 vol % in order to additionally stabilize the structure and thus improve its mechanical properties. The results of mechanical properties showed, that compressive strength was increased in all 20 specimens, partially due to the increased density as well as to the fibre addition. Flexural strength on the other hand was the most improved in the samples where PP and PVA fibres were added. The samples with the addition of B and GW fibres on the other hand showed only small or no improvement in flexural strength in comparison to the referenced sample. Additionally, the microstructure of used fibres and selected foams was also investigated by the means of SEM analysis.
Ključne besede: fibers, alkali activated foams, properties
Objavljeno v DiRROS: 31.01.2024; Ogledov: 117; Prenosov: 48
.pdf Celotno besedilo (4,05 MB)
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Cysteine proteinase inhibitors stefin A and stefin B in operable carcinoma of the head and neck : Inhibitorji cisteinskih proteinaz stefin A in stefin B pri operabilnem karcinomu glave in vratu
Primož Strojan, Marjan Budihna, Alojz Šmid, Branka Svetic, Ivan Vrhovec, Janko Kos, Janez Škrk, 2002, izvirni znanstveni članek

Povzetek: Purpose. To evaluate the significance of cysteine proteinase inhibitors stefins (Stefs) A and B for a treatment decision and prognosis in operable squamous cell carcinoma of the head and neck (SCCHN). Patients and methods. Stefs A and B concentrations were determined immunobiochemically using ELISAs in cytosols prepared from the tumor and adjacent normal mucosa from 91 patients with operable SCCHN. The median follow-up period of patients alive atthe close-out date was 5.8 years (range, 5-9.3 years). Results. Stef A concentrations were significantly higher in tumor compared to normal mucosa (FM.05). When a subgroup with clinically palpable nodes) at presentation was taken into consideration (n=57), a significant difference in Stef A (P=0.03) and Stef B (P=0.02) concentrations between those with negative and positive necks, as determined on histopathological examination, was observed. On the univariate survival analysis, higher Stefsć concentrations turned to be prognostically advantageous. Stef A proved its independent prognostic significance also on multivariate setting. Conclusions. With the capability todifferentiate between the pN0- and pN+-stages of the disease in the patientsoriginally presented as node-positive, Stefs A and B could be useful markers when deciding on the extent of neck surgery. In addition, both Stefs proved to be reliable prognosticators for survival in patients with operable SCCHN.
Objavljeno v DiRROS: 31.01.2024; Ogledov: 118; Prenosov: 29
.pdf Celotno besedilo (114,91 KB)

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A brief overview of the tumor vaccines through the last decade
Srdjan Novaković, Barbara Jezeršek Novaković, 2002, pregledni znanstveni članek

Povzetek: How to destroy cancer cells without damaging the normal cells? How to make conventional methods of systemic cancer treatment that predominantly comprise cytotoxic drugs more selective and prevent the development of drug resistance?There is an abundance of such guestions that do not have simple answers. If, a few years ago, unselective cytotoxic drugs were the method of choice for the treatment of cancer, in the last 25 years we are witnessing therapid transition of immunotherapy from the laboratories to the clinics. Among the most attractive and promising immunotherapies for cancer, a special place is reserved for tumor vaccines. Exploiting the latest knowledge in immunology, tumor physiology, as well as in molecular biology, many outstanding approaches for the creation of tumor vaccines have been developed.With no intention to be comprehensive, in the present article some of those approaches are reviewed.
Objavljeno v DiRROS: 31.01.2024; Ogledov: 131; Prenosov: 28
.pdf Celotno besedilo (97,46 KB)

36.
High-temperature oxidation of boiler steels at 650 °C
Jaka Burja, Barbara Šetina, Borut Žužek, Tilen Balaško, 2023, izvirni znanstveni članek

Povzetek: This study presents a comprehensive investigation of the formation, composition and behaviour of oxide layers during the high-temperature oxidation of four different steel alloys (16Mo3, 13Cr, T24 and P91) at a uniform temperature of 650 °C. The study is aimed at assessing the oxidation damage due to short-term overheating. The research combines CALPHAD (CALculation of PHAse Diagrams) calculations, thermogravimetric analysis (TGA) and advanced microscopy techniques, in- cluding scanning electron microscopy (SEM) and electron backscatter diffraction (EBSD), to elucidate the complex mechanisms controlling oxidation kinetics and oxide layer development. CALPHAD calculations were used to determine the thermodynamically stable phases for each steel type at 650 ◦C and different oxygen activities. The results showed different phase compositions, highlighting the importance of the chromium content in steel for the formation of oxide layers. The different oxidation kinetics and oxide layer compositions are presented and associated with the increased risk of material degradation due to overheating. These results have significant implications for industrial applications, mainly the susceptibility to oxidation of low-alloyed steels like 16Mo3 and 13 Cr and contribute to a deeper understanding of oxidation processes in steels.
Ključne besede: high-temperature oxidation, thermogravimetric analysis, kinetics, CALPHAD, boiler steels, SEM, EBSD
Objavljeno v DiRROS: 26.01.2024; Ogledov: 189; Prenosov: 77
.pdf Celotno besedilo (12,99 MB)
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Patogenost izolatov izbranih vrst gliv na Pinus sylvestris L. IN P. nigra Arnold
Ana Brglez, Barbara Piškur, Nikica Ogris, 2023, izvirni znanstveni članek

Povzetek: Na sadikah rdečega in črnega bora smo testirali patogenost osmih izbranih izolatov gliv (Corinectria fuckeliana, Diaporthe eres, Diplodia pinea, Fusarium sp. 1 in 2, Fusicolla sp., Nectria dematiosa in Tympanis sp.), ki smo jih izolirali iz obolelih borovih dreves v Sloveniji v letih 2020 in 2021. Inokulirali smo skupno 115 sadik borov (vključno s kontrolo), periodično smo preverjali njihovo zdravstveno stanje in ob prvih znakih sušenja opravili reizolacije iz robov nastalih nekroz. Reizolacije so bile uspešne le v primeru inokulacije z vrstami gliv Diplodia pinea, Diaporthe eres in Fusarium sp. 2. Povprečna dolžina nekroz sadik rdečega bora, inokuliranih z D. pinea, Di. eres in Tympanis sp., se je statistično značilno razlikovala od kontrolnih sadik (p < 0,05). Pri sadikah črnega bora pa so se za statistično značilne izkazale povprečne dolžine nekroz pri kontroli in inokulacijah z glivama D. pinea in Tympanis sp. (p < 0,05).
Ključne besede: test patogenosti, reizolacije, Pinus sylvestris, rdeči bor, Pinus nigra, črni bor
Objavljeno v DiRROS: 25.01.2024; Ogledov: 355; Prenosov: 136
.pdf Celotno besedilo (2,17 MB)
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40.
Antibodies to p53 - can they serve as tumor markers in patients with malignantlymphomas?
Barbara Jezeršek Novaković, Srdjan Novaković, 2000, izvirni znanstveni članek

Povzetek: Background. Tumor suppressor gene p53 is mutated in approximately 21% of patients with nonHodgkin's lymphomas (the percentage varying from 0 up to 67% depending upon the histological type). Most of the mutations are point missense mutations resulting in nuclear accumulation of altered protein. Roughly one third of patients with overexpression of p53 protein develop circulating anti p53 antibodies. The present study was aimed at defining the usefulness of serial serological determinations of autoantibodies to p53 for clinical follow up of NHL patients. Patients and methods. Serum levels of antibodies to p53 were determined in various time intervals in three lymphoma patients (who had elevated serum levels at the time of diagnosis) for maximum two years using the commercially available ELISA kit p53-Autoantikoerper ELISA2. Generation. Results. In all three cases the temporal patterns of anti p53 antibodies reflected accurately disease progression or regression, and even foretold a relapse ten months in advance. The reflection of disease regression by autoantibodies lagged approximately three months behind the morphological disappearance of the disease due to a long half life of the antibodies. Conclusion. Our results confirmed the usefulness of antibodies to p53 as tumor markers for follow up of lymphoma patients, yet the subset of patients that could be appropriately followed up with this method is very limited due to the low proportion of patients that develop immune response to p53 protein.
Objavljeno v DiRROS: 25.01.2024; Ogledov: 149; Prenosov: 32
.pdf Celotno besedilo (397,81 KB)

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