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Iskalni niz: "vrsta gradiva" (1) AND "polno besedilo" AND "organizacija" (Onkološki inštitut Ljubljana) .

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1.
Recurrence of carcinoma of the lower lip treated by interferon and irradiation
Boris Jančar, 2007, strokovni članek

Objavljeno v DiRROS: 21.02.2024; Ogledov: 11; Prenosov: 2
.pdf Celotno besedilo (97,73 KB)

2.
Assessment of differential expression of oncogenes in adenocarcinoma of stomach with fluorescent labeling and simultaneous amplification of gene transcripts
Uroš Rajčević, Petra Hudler, Gordan Mijovski, Gregor Gorjanc, Georg Hölzl, Stanislav Repše, Robert Juvan, Milena Kovač, Christian G. Huber, Radovan Komel, 2007, izvirni znanstveni članek

Povzetek: Background. Gastric cancer is one of the leading malignancies with a poor prognosis and low survival rates. Although the mechanisms underlying its development are still unknown, there is a consensus that genetic instability, inactivation of tumor suppressor genes and over-expression of oncogenes are involved in the early and late stages of gastric carcinogenesis. In the present study we wanted to display differential expression of seven oncogenes,namely CCNE1, EGF, ERBB3, FGF4, HRG1, HGFR and TDGF1. Patients and methods. We employed a method based on the multiplex reverse transcription polymerase chain (RT-PCR) method with a fluorescence detection. Results. More than half of patients (74.3%) out of total 74 with gastric adenocarcinoma had over-expressed at least one oncogene, with the exception of FGF4, which was expressed in tumor tissue of less than one third of patients. 56.8% of the patients patients showed over-expression of two or more oncogenes. Conclusions. Patients with precancerous lesions had elevated levels of TDGF1 or cripto-1 (64.9%) and CCNE1 (57.1%), suggesting that they could be used as markers for an early detection of malignant changes in stomach. Finally, the fluorescent multiplex RT-PCR method could be of value for rapid assessment of oncogene mRNA levels in small samples of tumor or precancerous biopsies.
Objavljeno v DiRROS: 20.02.2024; Ogledov: 17; Prenosov: 5
.pdf Celotno besedilo (86,60 KB)

3.
Subchronic exposure of rats to sublethal dose of microcystin-YR induces DNA damage in multiple organs
Metka Filipič, Bojana Žegura, Bojan Sedmak, Irena Horvat-Žnidaršič, Aleksandra Milutinović Živin, Dušan Šuput, 2007, izvirni znanstveni članek

Povzetek: Background. Microcystins (MCs) are cyclic heptapeptides that are considered tobe liver specific toxins. They are potent tumour promoters and recent studies indicate that they are also genotoxic. In this study we measured DNA damage in lymphocytes, liver, kidney (cortex and medulla), lung, spleen and brain cells of male Fisher F344 rats that were exposed to sublethal dose (every second day 10 Ugžkg b.w.č i.p) of microeysrin-YR (MCYR) for one month. Methods. At the end of exposure the animals were sacrificed, the lymphocytes were isolated from blood taken from jugular vein, liver cells were obtained byperfusion with collagenase A and the cells from other organs were isolated by incubating small tissue pieces with eollagenase A. The DNA damage in isolated cells was measured with the single cells gel electrophoresis (SCGE) also called the comet assay. Results. A significant increase of the % tail DNAin MCYR-exposed animals compared to the nonexposed control ones was observed in brain (2.5 fold), liver (2.1 fold), kidney medulla (1.9 fold), kidney cortex (1.8 fold) and lung (1.7 fold) cells, while the DNA from lymphocytes and spleen cells was not affected. Conclusion. This study demonstrated that subehronic exposure to sublethal doses of MCs can induce systemicgenotoxicity in mammals, and it affects not only the liver but also other vital organs.
Ključne besede: DNA damage, comet assay, cyanobacteria, bacterial toxins, rats, inbred F344
Objavljeno v DiRROS: 20.02.2024; Ogledov: 12; Prenosov: 3
.pdf Celotno besedilo (142,90 KB)

4.
5.
Mb. Bowen and squamous-cell carcinoma on the eczematous skin
Boris Jančar, 2007, strokovni članek

Objavljeno v DiRROS: 20.02.2024; Ogledov: 18; Prenosov: 3
.pdf Celotno besedilo (131,84 KB)

6.
In vivo dosimetry with diodes in rectal cancer patients
Andrej Strojnik, 2007, izvirni znanstveni članek

Objavljeno v DiRROS: 20.02.2024; Ogledov: 16; Prenosov: 4
.pdf Celotno besedilo (186,07 KB)

7.
Kidney cancer
Mirjana Rajer, 2007, strokovni članek

Objavljeno v DiRROS: 20.02.2024; Ogledov: 21; Prenosov: 3
.pdf Celotno besedilo (213,38 KB)

8.
Basal cell carcinoma on the left cheek
Boris Jančar, 2007, strokovni članek

Objavljeno v DiRROS: 20.02.2024; Ogledov: 14; Prenosov: 3
.pdf Celotno besedilo (1,83 MB)

9.
Basic Clinical Radiobiology Course Ljubljana (Slovenia), 21.-25. May 2006 : view from local participant
Mirjana Rajer, 2007, drugi sestavni deli

Objavljeno v DiRROS: 20.02.2024; Ogledov: 18; Prenosov: 5
.pdf Celotno besedilo (66,97 KB)

10.
Editoral [!]
Gregor Serša, 2007, predgovor, uvodnik, spremna beseda

Objavljeno v DiRROS: 20.02.2024; Ogledov: 23; Prenosov: 3
.pdf Celotno besedilo (29,27 KB)

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