431. The potential for EVITA project e-KPIs to be used by Road AuthoritiesDarko Kokot, 2021, objavljeni znanstveni prispevek na konferenci Povzetek: Planning different strategies in road maintenance is one of the most important activities inroad asset management. Assessment of different strategies and their comparison can be done by implementing an appropriate measure - Key Performance Indicators (KPIs). KPIs are currently used in many Road Authorities, and systematic research on the subject and development of indicators has been ongoing for many years. The Conference of European Directors of Roads (CEDR) funded project “EVITA - Environmental Performance Indicators for the Total Road Infrastructure Assets” aimed at developing and integrating new and existing environ-mental KPIs (e-KPIs) into the asset management process, taking into account the expectations of different stakeholders (users, operators, residents, etc.). The research focus was on environmental areas: Noise, with KPIs on day-evening-night & night noise, exposed population, population with sleep disturbance; Air, with KPIs on CO2, NOx, NO2 and PM10 emissions; Water, with KPIs on water quality and salting of roads; and Natural resources and GHG emissions, with KPIs on resource consumption and CO2e calculation. The project outputs were a set of e-KPIs produced after a comprehensive investigation of the state of the art during the project. The main benefit of this project is therefore to provide an applicable solution for the environmental assessment of different road infrastructure assets and to describe the expectations of different stakeholders in form of objective indicators. The ‘User Evaluation Trial’ phase of the project was used to gather feedback on the potential of e-KPIs to be used by national Road Authorities across Europe. Two Slovenian Road Authorities and one each from Denmark and Sweden were involved. The Slovenian Authorities provided input data for case studies, while all evaluated the proposed e-KPIs from their own perspective, taking into account national conditions and specificities.
Ključne besede: EVITA, environmental performance indicator, users’ feedback, stakeholder’ expectations
Objavljeno v DiRROS: 22.02.2024; Ogledov: 119; Prenosov: 66
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432. CoDEC : connected data for road infrastructure asset managementSukalpa Biswas, Jacques Proust, Tadas Andriejauskas, Alex Wright, Carl van Geem, Darko Kokot, António Antunes, Vânia Marecos, José Barateiro, Shubham Bhusari, Uros Jovanovic, 2021, objavljeni znanstveni prispevek na konferenci Povzetek: Road infrastructure asset management is rapidly transforming into a digital environment where data accessibility, effective integration and collaboration and accessibility from different sources and assets are key. However, current asset management processes are not yet fully integrated or linked, and there are incompatibilities between various systems and platforms that limit the ability to integrate asset management with BIM. The CoDEC project has sought to understand the current status of information management for assets, including inventory, condition and new data sources such as sensors and scanning systems, to identify the challenges and needs for linking and integrating different data sets to support effective asset management. As a result, CoDEC has developed a data dictionary framework to help link/integrate static and dynamic data for the "key" infrastructure assets (road pavements, bridges, tunnels). This will enable BIM and Asset Management Systems (AMS) to exchange data and help optimise and integrate data management across systems and throughout the different asset lifecycle phases, from build to operation. This work will be followed up with three pilot projects to demonstrate the feasibility of integrating asset data from various sources through linked data/semantic web technology to build the connection between AMS and BIM platforms.
Ključne besede: CoDEC, asset managemen, asset data, data dictionary, linked data, BIM, ontology
Objavljeno v DiRROS: 22.02.2024; Ogledov: 154; Prenosov: 58
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433. Volumetric view on asphalt mixtureMarjan Tušar, Mojca Ravnikar Turk, Lidija Ržek, 2023, objavljeni znanstveni prispevek na konferenci Povzetek: An asphalt layer consists of stone aggregates, binder and air voids. The content of air voids (Vmin and Vmax), the voids filled with bitumen (VFBmin and VFBmax), the content of air voids in stone aggregates (VMAmin and VMAmax) and volume content of bitumen (VBmin) should be determined for each type of asphalt mixture. The volumetric properties of asphalt layer listed above are important parameters for assessing the properties of asphalt and are usually first presented in the requirements for produced asphalt mixtures and built in asphalt layers. Visualization of volumetric properties is important for understanding the composition of the produced asphalt mixture. The most appropriate is a triangular representation of the volumetric requirements for three main components of asphalt layer (stone, bitumen and air).
Ključne besede: volumetric representation, asphalt mixture, void content, voids in aggregate
Objavljeno v DiRROS: 22.02.2024; Ogledov: 120; Prenosov: 56
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435. Assessment of differential expression of oncogenes in adenocarcinoma of stomach with fluorescent labeling and simultaneous amplification of gene transcriptsUroš Rajčević, Petra Hudler, Gordan Mijovski, Gregor Gorjanc, Georg Hölzl, Stanislav Repše, Robert Juvan, Milena Kovač, Christian G. Huber, Radovan Komel, 2007, izvirni znanstveni članek Povzetek: Background. Gastric cancer is one of the leading malignancies with a poor prognosis and low survival rates. Although the mechanisms underlying its development are still unknown, there is a consensus that genetic instability, inactivation of tumor suppressor genes and over-expression of oncogenes are involved in the early and late stages of gastric carcinogenesis. In the present study we wanted to display differential expression of seven oncogenes,namely CCNE1, EGF, ERBB3, FGF4, HRG1, HGFR and TDGF1. Patients and methods. We employed a method based on the multiplex reverse transcription polymerase chain (RT-PCR) method with a fluorescence detection. Results. More than half of patients (74.3%) out of total 74 with gastric adenocarcinoma had over-expressed at least one oncogene, with the exception of FGF4, which was expressed in tumor tissue of less than one third of patients. 56.8% of the patients patients showed over-expression of two or more oncogenes. Conclusions. Patients with precancerous lesions had elevated levels of TDGF1 or cripto-1 (64.9%) and CCNE1 (57.1%), suggesting that they could be used as markers for an early detection of malignant changes in stomach. Finally, the fluorescent multiplex RT-PCR method could be of value for rapid assessment of oncogene mRNA levels in small samples of tumor or precancerous biopsies.
Objavljeno v DiRROS: 20.02.2024; Ogledov: 115; Prenosov: 32
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436. Subchronic exposure of rats to sublethal dose of microcystin-YR induces DNA damage in multiple organsMetka Filipič, Bojana Žegura, Bojan Sedmak, Irena Horvat-Žnidaršič, Aleksandra Milutinović Živin, Dušan Šuput, 2007, izvirni znanstveni članek Povzetek: Background. Microcystins (MCs) are cyclic heptapeptides that are considered tobe liver specific toxins. They are potent tumour promoters and recent studies indicate that they are also genotoxic. In this study we measured DNA damage in lymphocytes, liver, kidney (cortex and medulla), lung, spleen and brain cells of male Fisher F344 rats that were exposed to sublethal dose (every second day 10 Ugžkg b.w.č i.p) of microeysrin-YR (MCYR) for one month. Methods. At the end of exposure the animals were sacrificed, the lymphocytes were isolated from blood taken from jugular vein, liver cells were obtained byperfusion with collagenase A and the cells from other organs were isolated by incubating small tissue pieces with eollagenase A. The DNA damage in isolated cells was measured with the single cells gel electrophoresis (SCGE) also called the comet assay. Results. A significant increase of the % tail DNAin MCYR-exposed animals compared to the nonexposed control ones was observed in brain (2.5 fold), liver (2.1 fold), kidney medulla (1.9 fold), kidney cortex (1.8 fold) and lung (1.7 fold) cells, while the DNA from lymphocytes and spleen cells was not affected. Conclusion. This study demonstrated that subehronic exposure to sublethal doses of MCs can induce systemicgenotoxicity in mammals, and it affects not only the liver but also other vital organs.
Ključne besede: DNA damage, comet assay, cyanobacteria, bacterial toxins, rats, inbred F344
Objavljeno v DiRROS: 20.02.2024; Ogledov: 126; Prenosov: 33
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440. Rheological behaviors of waste polyethylene modified asphalt binder : Statistical analysis of interlaboratory testing resultsDi Wang, Andrea Baliello, Gustavo Pinheiro, Lily D. Poulikakos, Marjan Tušar, Kamilla Vasconcelos, Muhammad Rafiq Kakar, Laurent Porot, Emiliano Pasquini, Gaspare Giancontieri, Chiara Riccardi, Marco Pasetto, Davide Lo Presti, Augusto Cannone Falchetto, 2023, izvirni znanstveni članek Povzetek: This article investigated the effect of waste polyethylene (PE) on the modified asphalt binders’ rheological behavior from a statistical point of view. The interlaboratory testing results from the RILEM Technical Committee 279 Valorization of Waste and Secondary Materials for Roads Task Group 1 were used for this purpose. First, an unaged 70/100 penetration graded neat binder was selected as the reference material. Next, a single 5 % content of waste PE additives (PE-pellets and PE-shreds) was mixed with a 95 % neat binder to prepare two PE modified binders. Then, dynamic shear rheometer–based temperature-frequency sweep tests were performed over a wide range of temperatures and frequencies to evaluate the rheological properties of these three binders. Different rheological behaviors were observed in the isochronal plots at high temperatures. Based on a reproducibility precision requirement proposed for phase angle, 28°C was set as the transition temperature across the rheological behaviors. Next, according to the three rheological behaviors defined in a previous study by the authors, statistical analysis was introduced to identify sensitive rheological parameters and determine the thresholds. Results indicate that the phase angle measured above 28°C and 1.59 Hz can be used as a sensitive parameter to discriminate the three rheological behaviors of PE modified binders. The thresholds among different behaviors were also calculated as an example for phase angle measured at the highest common testing temperature of 70°C. Additional experimental evaluations on more types of PE modified binders, especially at intermediate and high temperatures, are recommended to better understand their influence on the rheological behavior of PE modified binders.
Ključne besede: bitumen, polietilen, reologija, medlaboratorijska primerjava
Objavljeno v DiRROS: 20.02.2024; Ogledov: 112; Prenosov: 49
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