1. Oral treatment with etoposide in small cell lung cancer - dilemmas and solutionRenata Režonja, Lea Knez, Tanja Čufer, Aleš Mrhar, 2013, pregledni znanstveni članek Povzetek: Background. Etoposide is a chemotherapeutic agent, widely used for the treatment of various malignancies, including small cell lung cancer (SCLC), an aggressive disease with poor prognosis. Oral etoposide administration exhibits advantages for the quality of life of the patient as well as economic benefits. However, widespread use of oral etoposide is limited by incomplete and variable bioavailability. Variability in bioavailability was observed both within and between patients. This suggests that some patients may experience suboptimal tumor cytotoxicity, whereas other patients may be atrisk for excess toxicity. Conclusions. The article highlights dilemmas as well as solutions regarding oral treatment with etoposide by presenting and analyzing relevant literature data. Numerous studies have shown that bioavailability of etoposide is influenced by genetic, physiological and environmental factors. Several strategies were explored to improve bioavailability and to reduce pharmacokinetic variability of oral etoposide, including desired and undesired drug interactions (e.g. with ketoconazole), development of suitable drug delivery systems, use of more water-soluble prodrug of etoposide, and influence on gastric emptying. In addition to genotype-based dose administration, etoposide is suitable for pharmacokinetically guided dosing, which enables dose adjustments in individual patient. Further, it is established that oral and intravenous schedules of etoposide in SCLC patients do not result in significant differences in treatment outcome, while results of toxicity are inconclusive. To conclude, the main message of the article is that better prediction of the pharmacokinetics of oral etoposide may encourage its wider use in routine clinical practice.
Ključne besede: oral etoposide, bioavailability, pharmacokinetic variability, small cell lung cancer, treatment
Objavljeno v DiRROS: 22.03.2024; Ogledov: 79; Prenosov: 27
 Celotno besedilo (465,72 KB) |
2. Variability of generative offspring of field maple (Acer campestre L.) in nursery testingDalibor Ballian, Mirzeta Memišević Hodžić, Miroslav Murlin, Stjepan Kvesić, 2022, izvirni znanstveni članek Povzetek: Field maple (Acer campestre L.) is naturally distributed in most of Europe, with the exception of its northern parts. Field maple can serve as a valuable model for researching the sensitivity of its populations to habitat fragmentation, considering the lack of silvicultural treatments in its stands. The research aims to determine the interpopulation and intrapopulation variability of field maple populations from Bosnia and Herzegovina in the nursery test.The authors researched measured root collar diameter, height, observed forkness and calculated slenderness coefficient of the one-year-old generative material from 18 Bosnian-Herzegovinian populations of field maple, produced in the nursery of Žepče. The descriptive statistics and variance analysis was performed.All analyzed traits showed a high degree of intrapopulation as well as interpopulation variability, as confirmed by the analysis of variance. The highest average height was found in the provenance Bosanski Brod (46.08 cm) and the smallest in Bosanska Dubica (19.11 cm). Kreševo provenance had the highest average root neck dia-meter (8.27 mm) and Bosanska Dubica (5.24 mm) the lowest. A very low percentage of forkness (6.86%) was determined, and the values of the slenderness coefficient were acceptable for all provenances.The results indicate the need for further systematic research on this ecologically valuable species.
Ključne besede: field maple, variability, root collar diameter, height, forkness, slenderness
Objavljeno v DiRROS: 08.03.2023; Ogledov: 353; Prenosov: 163
Celotno besedilo (535,29 KB)
Gradivo ima več datotek! Več... |
3. Genetic variability of pedunculate oak (Quercus robur L.) at the Mediterranean margin of the distribution rangeMirzeta Memišević Hodžić, Barbara Fussi, Dušan Gömöry, Dalibor Ballian, 2021, pregledni znanstveni članek Povzetek: In Bosnia and Herzegovina, pedunculate oak (Quercus robur L.) occurs at the southern margin of its distribution range, close to the glacial refugia of this species. To assess the patterns of genetic diversity distribution at the rear edge of the Holocene colonization, we studied genetic variation in 20 pedunculate oak populations using 14 allozyme loci. Despite considerable differences among populations, neither the numbers of alleles nor genetic diversity showed any geographical trend within the studied area, although small isolated populations showed generally lower allelic richness. The Bayesian analysis of population structure indicated a kind of geographical pattern. We identified no signs of a recent bottleneck. The proximity to multiple glacial refugia explains the outcomes.
Ključne besede: pedunculate oak, allozyme, genetic variability, marginal populations, rear edge
Objavljeno v DiRROS: 22.07.2022; Ogledov: 522; Prenosov: 251
Celotno besedilo (833,22 KB)
Gradivo ima več datotek! Več... |
4. Morphologic variability of the Acer campestre L. populations in Bosnia and HerzegovinaStjepan Kvesić, Mirzeta Memišević Hodžić, Matjaž Čater, Dalibor Ballian, 2021, izvirni znanstveni članek Povzetek: Morphologic variability from 25 populations of Acer campestre L. in Bosnia and Herzegovina was analyzed. Morphometric structure of variability and between-population variability was performed based on 10 fruit-parameter characteristics and 19 leaf-parameter characteristics using multivariate statistical analysis. Results confirmed the separation of three submediterranean populations as a group in relation to other tested populations, from which the Banja Luka population is different. Measured leaf parameters were confirmed as a predominant carrier of the morphologic separation between populations. In other Acer species populations within A. monspessulanum and A. intermedium species are separated mainly by fruit and much less by leaf parameters. The southernmost submediterranean populations from Trebinje, Ljubuški, and Mostar regions have smaller leaf areas, which consequently places them within the same morphologic group; their variability is in tight connection with eco-geo-graphical factors, where the ecological distance is a much better predictor of morphological variability compared to geographical distance. The air temperature had the biggest influence on morphological variability regarding the highest in-between correlation. Achieved results may serve for the continuation of the research in other areas of Acer campestre to determine the interactive effect of ecological, geographical, climatic, and migrational factors on their morphologic population plasticity.
Ključne besede: differentiation, field maple, fruit, leaf, morphologic variability
Objavljeno v DiRROS: 03.01.2022; Ogledov: 686; Prenosov: 528
Celotno besedilo (960,45 KB)
Gradivo ima več datotek! Več... |
5. Independent infuence of age on heart rate recovery after flywheel exercise in trained men and womenDamir Zubac, Nandu Goswami, Vladimir Ivančev, Zoran Valić, Boštjan Šimunič, 2021, izvirni znanstveni članek Povzetek: The present study examined whether differences in the heart rate recovery following flywheel exercise cessation were associated with differences in maximal oxygen uptake (VO2 max.), age and sex in trained adults. Eleven men (age range 22-49 years, VO2 max.=43.6 +/- 7.6 mL kg min -1) and ten women (age range 20-53 years, VO2 max.=38.0 +/- 5.7 mL kg min%1) were randomly assigned to complete a squat-exercise on the flywheel ergometer set at three different moments of inertia, while their cardiovascular responses were continuously monitored. During the flywheel exercise the mean arterial pressure rose by ~35 to 40% (p=.001), and the increment was more robust in men than women. The cardiac index was two-fold greater across both sexes compared to the baseline (p=.001), while the rise in heart rate (~144 bpm) was more pronounced in women to compensate for their load-dependent stroke index decline (p=.001). The load-independent time-course changes in heart rate recovery markers were comparable between the sexes. When these indicators were pooled, a stepwise regression revealed age as the only relevant predictor of both fast and slow components of the heart rate recovery (~30 of the shared variance explained, p=.014). The present data suggest that the heart rate recovery declines with age, irrespective of sex, or well-preserved cardiorespiratory fitness in moderately-trained adults.
Ključne besede: training, exercise, Yo-Yo exercise, flywheel, heart rate variability, total peripheral conductance, oxygen uptake kinetics
Objavljeno v DiRROS: 11.06.2021; Ogledov: 959; Prenosov: 887
Celotno besedilo (1,64 MB)
Gradivo ima več datotek! Več... |
6. Differences in growth and log quality of Douglas-Fir (Pseudotsuga menziesii (Mirb.) Franco) provenancesPeter Smolnikar, Robert Brus, Kristjan Jarni, 2021, izvirni znanstveni članek Povzetek: Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) is a non-native conifer from western North America that was introduced into European forests at the end of the 19th century. Plantations of Douglas-fir in Europe have shown good performance, quality, and resilience to exacerbating climatic conditions. However, all these qualities strongly depend on provenance. A total of 1061 surviving trees of fifteen different Douglas-fir provenances were measured in a Slovenian provenance trial that was established within the framework of the 1966/1967 IUFRO seed collection program. We found significant differences among provenances with respect to survival rate, growth performance, and log quality. The total recorded yield of the 46-year-old stand was 602.9 m3/ha, and the average survival rate was 43%. The correlation of juvenile tree heights in 1985 and their average breast height diameters in 2017 is positive and significant. Based on vitality and diameter, the best performing provenances were Yelm and Cathlamet. The provenance with the best log quality assessed through branchiness is Jefferson (Olympic Peninsula, western Washington). All the most promising provenances for western Slovenia (Central Europe) originate from the low-altitude western coast of Washington (WACO), with the Cathlamet provenance showing the best combination of good growth, survival rate, and log quality
Ključne besede: coniferous plantation, IUFRO provenance trial, non-native species, variability, growth, branching
Objavljeno v DiRROS: 05.03.2021; Ogledov: 1066; Prenosov: 838
Celotno besedilo (510,73 KB)
Gradivo ima več datotek! Več... |
