1. Early manifestations, diagnostic pathways, and epilepsy in juvenile-onset Huntington disease : a three-patient case series and systematic reviewMirjana Perković-Benedik, Tanja Loboda, Katarina Benedik Kafol, Jan Kafol, Neli Bizjak, 2026, izvirni znanstveni članek Povzetek: Background: Juvenile-onset Huntington disease (JoHD) is a rare form of Huntington disease characterized by symptom onset at or before 20 years of age. Early manifestations are often non-choreic and may be attributed to developmental, psychiatric, movement, metabolic, or epileptic disorders. We described three molecularly confirmed cases and examined early manifestations, diagnostic pathways, and epilepsy. Methods: We conducted a retrospective case series and a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 systematic review of PubMed, Scopus, and Web of Science Core Collection through 5 July 2026. The strict patient-level synthesis required attributable onset at or before 20 years, patient-specific molecular confirmation of a pathogenic HTT repeat expansion, and extractable clinical data. Complementary aggregate or linked reports using closely aligned JoHD criteria were retained for context but excluded from patient-level calculations. Results: The cases included childhood-onset JoHD with drug-resistant epilepsy, adolescent-onset JoHD with progressive motor-cognitive decline and epilepsy in a known Huntington disease pedigree, and childhood-onset JoHD without available family history, in whom status epilepticus prompted renewed diagnostic evaluation. Ninety-three reports were included; of these, 81 contributed 228 unique patients and 12 provided complementary data. Early manifestations were heterogeneous and broadly consistent with previously described childhood-onset JoHD phenotypes. Diagnostic delay was extractable in 180/228 patients; among 172 with point estimates, the median was 4.0 years. Definite epilepsy was reported in 60/145 patients with ascertainable seizure status and was descriptively more frequent in childhood-onset (<10 years) than adolescent-onset (10–20 years) JoHD (49/84 [58.3%] vs. 11/57 [19.3%]). Conclusions: JoHD should be considered in children and adolescents with progressive multisystem neurological involvement, particularly when epilepsy occurs with developmental regression, gait or speech deterioration, pyramidal or extrapyramidal signs, basal-ganglia abnormalities, or a compatible family history.
Ključne besede: juvenile-onset Huntington disease, epilepsy, HTT CAG repeat expansion, basal ganglia, systematic review, seizures
Objavljeno v DiRROS: 26.08.2026; Ogledov: 100; Prenosov: 76
 Celotno besedilo (3,67 MB)
Gradivo ima več datotek! Več... |
2. Population effects of influenza vaccination in children and adolescents : systematic reviewMona Askar, Veronika Učakar, Thomas Harder, 2026, izvirni znanstveni članek Povzetek: Objectives To investigate indirect vaccine effectiveness (indirVE) of vaccination of children and adolescents with seasonal influenza vaccines against influenza-related outcomes occurring in other population groups. Methods We performed a systematic review of studies (randomized and non-randomized) on indirVE of vaccination of participants aged 6 months–17 years with tri- or quadrivalent seasonal influenza vaccines against influenza (lab-confirmed; non-lab-confirmed) occurring in contacts of vaccinated persons or members of the wider community (last search: 17th March 2024). GRADE certainty of evidence (CoE) was evaluated (PROSPERO: CRD42024546400). Results We identified 28 studies (5 randomized; 23 non-randomized). In community-based studies, indirect protection against laboratory-confirmed influenza (LCI) ranged from −38 % [95 % CI: −574 to 72] to 61 % [95 % CI: 8–83] (very low CoE). In household-based settings, indirVE against LCI varied between −151.2 % [95 % CI: −1194.6 to 51.3] and 39.4 % [95 % CI: 7.4 to 60.3] (very low CoE). In school-based settings, highly variable indirect effects were observed on LCI, hospitalization, emergency department visits and school/work absenteeism (very low CoE). Conclusions There is no clear evidence of indirect effects from influenza vaccination in children. While plausible, effect size is uncertain and varies by study design, population, and vaccine type. Stronger indirect effects appeared only when direct VE was high.
Ključne besede: systematic review, influenza vaccination, vaccination
Objavljeno v DiRROS: 08.07.2026; Ogledov: 248; Prenosov: 169
 Povezava na datoteko |
3. Exploring the potential and implications of digital tools in teaching academic writingEriada Çela, 2025, izvirni znanstveni članek Povzetek: This study employs a systematic literature review to explore the pedagogical potential and implications of integrating digital tools into academic writing instruction. The review synthesises empirical and theoretical studies, with the purpose of examining how digital feedback mechanisms, such as automated writing evaluation systems, artificial intelligence-powered assistants and multimodal platforms affect writing proficiency, support personalised learning and promote inclusive practices. The findings reveal that digital tools enhance surface-level accuracy, engagement and revision habits. However, their effectiveness is highly dependent on how they are thoughtfully integrated into teaching, customised for students’ needs and used to address ethical and equity challenges. This paper also investigates critical concerns, including academic integrity, algorithmic bias and the risk of overreliance on automation. Ultimately, the study underscores the importance of thoughtful integration, digital literacy and teacher guidance to ensure that the support provided by digital tools to improve academic writing development is fully aximised.
Ključne besede: pedagogy, digital tools, academic writing instruction, educational technology, systematic review
Objavljeno v DiRROS: 20.05.2026; Ogledov: 329; Prenosov: 281
Celotno besedilo (212,49 KB)
Gradivo ima več datotek! Več... |
4. Towards integrated ecosystem assessments : A literature review on linking ecosystem condition indicators to ecosystem servicesJoana Seguin, Daniela Ribeiro, Mateja Šmid Hribar, 2026, pregledni znanstveni članek Povzetek: Ecosystem services (ES) fundamentally depend on ecosystem condition (EC), yet many ES assessments still rely on land-cover proxies, risking biased assessment results as well as weak uptake, meaning limited application of results in decision-making contexts. This review provides a comprehensive overview of how EC indicators are used in ES assessments published between 2018 and 2022.
In total, 128 publications have been included in the review, from which 929 EC indicators with a direct or implicit link to one or more ES and 707 ES indicators have been documented. The recorded EC indicators were reclassified according to the Ecosystem Condition Typology (ECT) provided by the System of Environmental-Economic Accounting - Ecosystem Accounting (SEEA EA) and supplementary classes (ECT+). Our analysis identified a focus on terrestrial ecosystems, with under-representation of marine and less intensively managed ecosystems. Within the reclassified ECT and ECT+ indicators, chemical state EC indicators were prevalent, while landscape state and functional state metrics remained under-operationalised. Besides, the share of spatially explicit indicators was limited. Moreover, we found that a significant share of indicators, labelled as EC, were not EC indicators in the strict sense, but instead related to ecosystem extent, ES or stable environmental characteristics, leading to a conceptual blurring between condition, pressure, extent and service indicators. Analysing the link between EC and ES revealed that EC indicators were: (1) primarily quantitatively compared to ES or integrated into ES assessments and (2) most frequently linked to regulating ES. The reviewed literature showed a predominance of positive EC–ES relationships, confirming that ecosystems in better condition tend to support a higher supply of ES. In summary, our review identified progress towards integrated ES assessments, highlighted persistent gaps and stressed the importance of continued efforts to achieve the widespread implementation of EC-enabled ES assessments.
Ključne besede: systematic review, ecosystem state, ecosystem health, integration, EC-enabled, condition-service interrelation
Objavljeno v DiRROS: 14.04.2026; Ogledov: 353; Prenosov: 441
Celotno besedilo (980,50 KB)
Gradivo ima več datotek! Več... |
5. Electrosurgical devices in gynecologic oncology : a systematic review of clinical studiesEkaterina Lazhovska, Kristina Drusany Starič, Katrina Mencin, Marina Jakimovska, 2026, pregledni znanstveni članek Povzetek: Introduction: Electrosurgical instruments are a crucial component in the surgical treatment of gynecologic malignancies, enabling precise dissection and effective hemostasis, influencing blood loss, operative time and complication rates. Considering their importance in oncological outcomes and increasing variety, comparative data in the literature remains limited. Our aim is to comprehensively assess and compare clinical outcomes across electrosurgical modalities in gynecologic cancer surgery. Methods: Following PRISMA guidelines, we performed a systematic search of three electronic databases (PubMed, Cochrane Library, Scopus). Eligible studies since 2005 enrolled women (≥18 years) undergoing surgery for gynecological neoplasms, in which electrosurgical devices were used. Clinically relevant outcomes, such as intraoperative blood loss, operative time, perioperative complication rates, surgeon’s experience and length of hospital stay were compared. Results: 359 publications were reviewed after literature search, 10 of them fitted the inclusion criteria, 1 additional publication was added after references review. Most of the studies (36.4%) evaluated cervical cancer only, followed by studies that included both cervical and endometrial cancer (27.3%), while 18.2% of the studies focused on endometrial and ovarian cancer each. Majority of the articles (82%) evaluated advanced electrosurgical devices alone or in comparison with standard electrosurgery or conventional methods. LigaSure was the most commonly used advanced electrosurgical device, followed by THUNDERBEAT, PlasmaJetTM, PlasmaKinetic tissue management system and ERBE BiClamp® forceps. All of the studies assessed more than one perioperative outcome, with the most common being estimated blood loss, operative time and duration of hospitalization. Discussion: Despite heterogeneous design and outcomes, most findings suggest that advanced electrosurgical devices are associated with mostly better perioperative outcomes in oncological patients undergoing surgery. It can be concluded that the effectiveness of the device and the appropriate instrument selection differs between malignancies, depending on the cancer type and operative procedure performed. Given the diversity of the studies we believe that additional well-designed studies using standardized outcomes sets are needed.
Ključne besede: advanced bipolar vessel sealing, electrosurgical devices, gynecological cancer, surgical outcomes, systematic review
Objavljeno v DiRROS: 31.03.2026; Ogledov: 395; Prenosov: 256
Celotno besedilo (591,91 KB)
Gradivo ima več datotek! Več... |
6. The choice of study designs of diagnostic accuracy using Borrelia specific IgG and IgM antibodies for the diagnosis of Lyme borreliosisRam Benny Dessau, Alice Raffetin, Randi Eikeland, Volker Fingerle, Anna J. Henningsson, Klaus-Peter Hunfeld, Benoit Jaulhac, Reto Lienhard, Per-Eric Lindgren, Franc Strle, 2025, pregledni znanstveni članek Povzetek: Background: Laboratory diagnosis of Lyme borreliosis (LB) is used in a variety of clinical settings where a range of other diagnoses may be considered. Therefore, it is essential that diagnostic accuracy studies and literature reviews consider information from different types of studies and choices of sample groups. The quality of patient selection is important to minimize the risk of misclassification. This narrative review was inspired by systematic reviews where nearly all studies on the diagnostic accuracy for LB tests were determined as biased and having low quality based solely on study design considerationsdnot the clinical relevance. Objectives: To propose flexible design and interpretation of studies used to assess diagnostic accuracy in clinical microbiology. Sources: Criteria for rating the quality of studies were discussed among the ESCMID study group for LB ESGBOR (The ESCMID study group for Lyme borreliosis). The literature was searched for similar methodological discussions. Content: Knowledge of antibody reactivity in the background population across various clinical patient groups with and without infection should consider variations in clinical presentation and duration of disease. Case-control studies are the most frequently used design and were judged particularly instrumental in assessing serologic testing. However, clinical and epidemiological studies not specifically intended for diagnostic accuracy may also contribute estimates of sensitivity and specificity. Systematic reviews should focus on the application of the diagnostic assay for the individual patient in various clinical settings, rather than seeking an unbiased average. Different LB sample groups and controls for test panels are discussed. Implications: Case-control (two-gate design) studies, case series, and seroprevalence studies representing the range of LB in different populations are necessary to assess the diagnostic accuracy of serological tests for LB. A broader range of studies should be considered for inclusion in systematic reviews of diagnostic accuracy
Ključne besede: case-control design, cross-sectional design, diagnostic accuracy, diagnostic antibody tests, diagnostic test accuracy, Lyme borreliosis, research design, serology, systematic review
Objavljeno v DiRROS: 09.03.2026; Ogledov: 477; Prenosov: 376
Celotno besedilo (418,51 KB)
Gradivo ima več datotek! Več... |
7. Ethical aspects of limiting end-of-Life treatment of adult patients at the primary healthcare level in family and emergency medicine : a systematic reviewMeta Krajnc, Urh Grošelj, Erika Zelko, 2025, izvirni znanstveni članek Povzetek: Background Decisions to limit treatment near the end of life are challenging and common in primary healthcare, especially in family and emergency medicine. Objectives This review aimed to [1] examine the evidence on the decision-making process regarding treatment limitation in end-of-life care in family and emergency medicine [2], identify associated ethical considerations, and [3] compare the evidence between family and emergency medicine. Methods A systematic search of PubMed and Embase was conducted for studies published between 2004 and 2024. Eligible studies focused on ethical aspects of limiting treatment in end-of-life care in family and emergency medicine, such as decision-making processes, influencing factors, and ethical considerations. Quality was assessed using adapted Critical Appraisal Skills Programme checklists. Results Of the 477 identified studies, 12 met the inclusion criteria. Eight papers reported research on treatment limitations in emergency medical care, two in family/general medicine, one on medication discontinuation in endof-life care, and one on goals-of-care conversations in emergency departments. Patients, families and colleagues were involved to varying degrees. Family physicians were rarely included in emergency care decisions, despite their potential to align care with patient preferences. Decision-making in emergency medicine was characterized by rapid, protocol-driven processes, often constrained by time and workload, while decisions in family medicine relied on longitudinal patient relationships and clinical judgment, though lacking formalized guidelines. Key factors influencing decisions on limiting treatment included patient and family wishes and values, illness severity, prognosis, previous functional limitation, age, poor predicted quality of life and cultural and religious contexts. Conclusion Our review showed that decisions regarding treatment limitations in primary care settings remain underexplored, particularly in family medicine. More research and development of clearer guidelines, as well as enhanced collaboration between family and emergency physicians, could improve primary end-of-life care.
Ključne besede: ethics, end-of-life care, treatment limitation, primary care, family medicine, emergency medicine, systematic review
Objavljeno v DiRROS: 23.02.2026; Ogledov: 550; Prenosov: 291
Celotno besedilo (1,12 MB)
Gradivo ima več datotek! Več... |
8. Predictors of adolescent well-being during school closures : a systematic review and secondary analysis of REDS data from SloveniaManja Veldin, Nina Pertoci, 2025, izvirni znanstveni članek Ključne besede: education, well-being, adolescence, predictors, covid-19, systematic review, REDS, regression models
Objavljeno v DiRROS: 29.12.2025; Ogledov: 1028; Prenosov: 427
Celotno besedilo (1011,96 KB)
Gradivo ima več datotek! Več... |
9. |
10. |
