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Povzetek: Background/Objectives: The aim of the present study was to assess the influence of physical activity on retinal microvascularization in patients with uveal melanoma (UM) and nevus. In addition, vascular differences between tumor and nevus patients as well as the interaction effect of physical activity (PA) and group on retinal microvascular density (MVD) were analyzed. Methods: This cross-sectional, observational clinical study was conducted at the outpatient ophthalmic oncology department at the Center for Integrated Oncology of the University Hospital Cologne (between April 2024 and July 2025). Patients with confirmed uveal melanoma or choroidal nevus were enrolled. Physical activity and retinal MVD via optical coherence tomography angiography were assessed. In addition, regression analyses were performed. Results: A total of 42 participants were enrolled with a mean age of 56.14 (±13.48) years (nevus) and 63.45 (±13.76) years (UM). UM eyes (N = 20) demonstrated significantly reduced MVD in both the superficial and deep layer compared to Nevus (N = 22, all p < 0.001, η2 = 0.155–0.190), whileUMeyes showed greater mean vessel length (B = 5.54, p = 0.009, η2 = 0.104). Physical activity was positively associated with MVD in the superficial layer, including vessel area density (B = 1.07, p = 0.022, η2 = 0.133) and vessel length density (B = 0.28, p = 0.028, η2 = 0.119), independent of group. No significant associations were found in the deep layer and no interaction effects between group and PA were detected. Conclusions: Our findings suggest that habitual PA is positively associated with retinal MVD in the superficial layer, independent of diagnostic group, and may partially counteract tumor-induced as well as treatment-related microvascular disruption. As a low-risk and accessible intervention, PA holds promise as a supportive strategy in the oncological management of UM.
Ključne besede: electrochemotherapy, bleomycin, immunotherapy, murine models, physical activity, uveal melanoma, optical coherence tomography angiography, tumor micro-environment, microvascular density
Objavljeno v DiRROS: 03.09.2026; Ogledov: 47; Prenosov: 38
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Ključne besede: food allergy, children, adequate nutrition, nitric oxide, physical activity, beetroot, football
Objavljeno v DiRROS: 15.06.2026; Ogledov: 276; Prenosov: 203
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Povzetek: Regular physical activity and exercise (PA) are cornerstones of diabetes care for individuals with type 1 diabetes. In recent years, the availability of automated insulin delivery (AID) systems has improved the ability of people with type 1 diabetes to achieve the recommended glucose target ranges. PA provides additional health benefits but can cause glucose fluctuations, which challenges current AID systems. While an increasing number of clinical trials and reviews are being published on different AID systems and PA, it seems prudent at this time to collate this information and develop a position statement on the topic. This joint European Association for the Study of Diabetes (EASD)/International Society for Pediatric and Adolescent Diabetes (ISPAD) position statement reviews current evidence on AID systems and provides detailed clinical practice points for managing PA in children, adolescents and adults with type 1 diabetes using AID technology. It discusses each commercially available AID system individually and provides guidance on its use in PA. Additionally, it addresses different glucose responses to PA and provides stratified therapy options to maintain glucose levels within the target ranges for these age groups.
Ključne besede: automated insulin delivery, continuous glucose monitoring, exercise, glucose, insulin pump, physical activity, position statement, type 1 diabetes
Objavljeno v DiRROS: 23.04.2026; Ogledov: 399; Prenosov: 426
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Povzetek: Purpose: The increasing prevalence of menopause-related discomforts, coupled with the potential for non-pharmacological interventions, underscores the need to explore lifestyle modifications such as physical activity (PA). This study aimed to evaluate the effects of pre-existing PA on the quality of life (QoL) in menopausal women. Method: Conducted between September 2022 and January 2023, the cross-sectional study utilized IBM SPSS Statistics (version 23) and included 138 women. Standardized QoL questionnaires (MENQOL and SF-36) and the Global Physical Activity Questionnaire (GPAQ) to assess their PA levels and QoL outcomes. Result: Among participants, 64% engaged in moderate-intensity PA, averaging 90 minutes per week in recreational activities, while spending 75 minutes per day sedentary. A significant inverse relationship was observed between total PA and menopause-related symptoms, with strong negative correlations in the Psychosocial (r = -0.398, p < 0.001) and Vasomotor (r = -0.284, p < 0.001) domains of MENQOL. Women who met the 150 minutes/week recommendation for moderate-to-vigorous physical activity (MVPA) reported significantly better psychological QoL (p = 0.025) as measured by SF-36. Furthermore, positive associations were noted between work-related PA and general health outcomes, suggesting that PA benefits extend across various health dimensions. Conclusions: These findings highlight the role of PA in improving menopausal QoL and emphasize the importance of incorporating personalized PA recommendations into menopausal care. Further research using objective PA measurements and a larger, more diverse cohort is recommended to confirm these results and provide deeper insights.
Ključne besede: women, menopause, menopausal symptoms, physical activity, MENQOL, SF-36
Objavljeno v DiRROS: 10.03.2026; Ogledov: 382; Prenosov: 261
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Povzetek: Introduction: Regular physical activity during pregnancy is associated with several maternal and neonatal health benefits. However, most studies focus on specific forms of exercise in low-risk populations, limiting generalizability. Objective: To investigate associations between regular physical activity during singleton pregnancy and perinatal outcomes using a national perinatal registry. Methods: A population-based cohort study was conducted using data from the Slovenian National Perinatal Information System (2013–2022), which included 190,331 singleton pregnancies. Regular physical activity was defined as any form of physical activity at least twice weekly throughout pregnancy. The outcomes analyzed included preterm birth (<37 and <32 weeks), preeclampsia, gestational hypertension, gestational diabetes mellitus (GDM), pelvic girdle pain, small-for-gestational-age (SGA) and large-for-gestational-age (LGA) neonates, cesarean delivery, urinary incontinence postpartum, and Apgar scores < 7 at 5 minutes. Multivariate logistic regression adjusted for parity, maternal age, BMI, prepregnancy hypertension and diabetes, and gestational weight gain. Results: Regular physical activity during pregnancy was reported by 69 % of the women. It was significantly associated with reduced odds of preterm birth (<37 weeks, aOR 0.658; <32 weeks, aOR 0.393), preeclampsia (aOR 0.719), gestational hypertension (aOR 0.708), pelvic girdle pain (aOR 0.808), SGA (aOR 0.903), LGA (aOR 0.902) and low Apgar scores (aOR 0.638). Physically active women with GDM were less likely to require insulin (aOR 0.768). No significant associations were found with cesarean delivery or urinary incontinence. Conclusion: Regular physical activity during pregnancy, regardless of specific type, was associated with improved perinatal outcomes without safety concerns. These findings highlight the potential benefits of encouraging physical activity during pregnancy in diverse populations.
Ključne besede: pregnancy, physical activity, perinatal outcome
Objavljeno v DiRROS: 27.02.2026; Ogledov: 524; Prenosov: 321
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