1. Risk of cancer after primary total hip replacement : the influence of bearings, cementation and the material of the stemVesna Levašič, Ingrid Milošev, Vesna Zadnik, 2018, izvirni znanstveni članek Povzetek: Background and purpose - Despite the increasing number of total hip replacements (THRs), their systemic influence is still not known. We have studied the influence of specific features of THRs-the bearing surface, the use of bone cement and the material of the stem-on the cancer incidence. Patients and methods - In a retrospective cohort study we identified 8,343 patients with THRs performed at Valdoltra Hospital from September 1, 1997 to December 31, 2009. Patient data were linked to national cancer and population registries. The standardized incidence ratios (SIR) and Poisson regression relative risks (RR) were calculated for all and specific cancers. Results - General cancer risk in our cohort was comparable to the population risk. Comparing with population, the risk of prostate cancer was statistically significantly higher in patients with metal-on-metal bearings (SIR =1.35); with metal-on-polyethylene bearings (SIR =1.30), with non-cemented THRs (SIR =1.40), and with titanium alloy THRs (SIR =1.41). In these last 3 groups there was a lower risk of hematopoietic tumors (SIR =0.69; 0.66 and 0.66 respectively). Risk of kidney cancer was significantly higher in the non-metal-on-metal, non-cemented, and titanium alloy groups (SIR =1.30; 1.46 and 1.41 respectively). Risk of colorectal and lung cancer was significantly lower in the investigated cohort (SIR =0.82 and 0.83, respectively). Risk for all cancers combined as well as for prostate and skin cancer, shown by Poisson analysis, was higher in the metal-on-metal group compared with non-metal-on-metal group (RR =1.56; 2.02 and 1.92, respectively). Interpretation - Some associations were found between the THRs' features, especially a positive association between metal-on-metal bearings, and specific cancers. Ključne besede: oncology, cancer registry, replacements, materials Objavljeno v DiRROS: 19.05.2025; Ogledov: 179; Prenosov: 87
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2. The Slovenian translational platform GlioBank for brain tumour research : identification of molecular signatures of glioblastoma progressionMetka Novak, Bernarda Majc, Marta Malavolta, Andrej Porčnik, Jernej Mlakar, Matjaž Hren, Anamarija Habič, Mateja Mlinar, Ivana Jovchevska, Neja Šamec, Alja Zottel, Marija Skoblar Vidmar, Tina Vipotnik-Vesnaver, Andrej Zupan, Alenka Matjašič, Saša Trkov, Dejan Georgiev, Aleksander Sadikov, Roman Bošnjak, Borut Prestor, Radovan Komel, Tamara Lah Turnšek, Barbara Breznik, 2025, izvirni znanstveni članek Ključne besede: biobank, biomarker, glioblastoma, tumour models, oncology Objavljeno v DiRROS: 28.01.2025; Ogledov: 320; Prenosov: 194
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4. EditorialDavid Ožura, 2024, predgovor, uvodnik, spremna beseda Ključne besede: medical journals, oncology, open access, editorial, bibliographic databases, citation index Objavljeno v DiRROS: 26.07.2024; Ogledov: 535; Prenosov: 330
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5. Imaging microvascular changes in nonocular oncological clinical applications by optical coherence tomography angiography : a literature reviewRok Hren, Gregor Serša, Urban Simončič, Matija Milanič, 2023, pregledni znanstveni članek Ključne besede: optical coherence tomography, angiography, endoscopy, oncology, skin carcinoma Objavljeno v DiRROS: 26.07.2024; Ogledov: 897; Prenosov: 349
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7. Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheresBarbara Breznik, Meng-Wei Ko, Christopher Tse, Po-Chun Chen, Emanuela Senjor, Bernarda Majc, Anamarija Habič, Nicolas Angelillis, Metka Novak, Vera Župunski, Jernej Mlakar, David Nathanson, Anahid Jewett, 2022, izvirni znanstveni članek Povzetek: Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since these cells can select and lyse therapy-resistant glioblastoma stem-like cells (GSLCs). Immunotherapy with super-charged NK cells has a potential as antitumor approach since we found their efficiency to kill patient-derived GSLCs in 2D and 3D models, potentially reversing the immunosuppression also seen in the patients. In addition to their potent cytotoxicity, NK cells secrete IFN-γ, upregulate GSLC surface expression of CD54 and MHC class I and increase sensitivity of GSLCs to chemotherapeutic drugs. Moreover, NK cell localization in peri-vascular regions in glioblastoma tissues and their close contact with GSLCs in tumorospheres suggests their ability to infiltrate glioblastoma tumors and target GSLCs. Due to GSLC heterogeneity and plasticity in regards to their stage of differentiation personalized immunotherapeutic strategies should be designed to effectively target glioblastomas. Ključne besede: glioblastoma, natural killer cells, translational oncology Objavljeno v DiRROS: 16.07.2024; Ogledov: 712; Prenosov: 511
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8. ▫$[^{18}\mathrm F]$▫FDG PET immunotherapy radiomics signature (iRADIOMICS) predicts response of non-small-cell lung cancer patients treated with pembrolizumabDamijan Valentinuzzi, Martina Vrankar, Nina Boc, Valentina Ahac, Žiga Zupančič, Mojca Unk, Katja Škalič, Ivana Žagar, Andrej Studen, Urban Simončič, Jens C. Eickhoff, Robert Jeraj, 2020, izvirni znanstveni članek Ključne besede: medical physics, medical imaging, oncology Objavljeno v DiRROS: 15.07.2024; Ogledov: 600; Prenosov: 190
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9. Impact of COVID-19 on cancer diagnosis and management in Slovenia : preliminary resultsVesna Zadnik, Ana Mihor, Sonja Tomšič, Tina Žagar, Nika Bric, Katarina Lokar, Irena Oblak, 2020, izvirni znanstveni članek Ključne besede: covid-19, oncology, oncology diagnosis, pandemic Objavljeno v DiRROS: 12.07.2024; Ogledov: 646; Prenosov: 323
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