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Iskalni niz: "ključne besede" (factors) .

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Glioblastoma in patients over 70 years of age
Uroš Smrdel, Marija Skoblar Vidmar, Aleš Smrdel, 2018, izvirni znanstveni članek

Ključne besede: glioblastoma, elderly, patients, prognostic factors, treatment
Objavljeno v DiRROS: 10.06.2024; Ogledov: 66; Prenosov: 23
.pdf Celotno besedilo (525,86 KB)

Leiomyosarcoma of the renal vein : analysis of outcome and prognostic factors in the world case series of 67 patients
Marko Novak, Andraž Perhavec, Katherine E. Maturen, Snežana Pavlović Djokić, Simona Jereb, Darja Eržen, 2017, izvirni znanstveni članek

Povzetek: Background Leiomyosarcoma is a rare malignant mesenchymal tumour. Some cases of leiomyosarcoma of the renal vein (LRV) have been reported in the literature, but no analysis of data and search for prognostic factors have been done so far. The aim of this review was to describe the LRV, to analyse overall survival (OS), local recurrence free survival (LRFS) and distant metastases free survival (DMFS) in LRV world case series and to identify significant predictors of OS, LRFS and DMFS. Methods Cases from the literature based on PubMed search and a case from our institution were included. Results Sixty-seven patients with a mean age of 56.6 years were identified; 76.1% were women. Mean tumour size was 8.9 cm; in 68.7% located on the left side. Tumour thrombus extended into the inferior vena cava lumen in 13.4%. All patients but one underwent surgery (98.5%). After a median follow up of 24 months, the OS was 79.5%. LRFS was 83.5% after a median follow up of 21.5 months and DMFS was 76.1% after a median follow up of 22 months. Factors predictive of OS in univariate analysis were surgical margins, while factors predictive of LRFS were inferior vena cava luminal extension and grade. No factors predictive of DMFS were identified. In multivariate analysis none of the factors were predictive of OS, LRFS and DMFS. Conclusions Based on the literature review and presented case some conclusions can be made. LRV is usually located in the hilum of the kidney. It should be considered in differential diagnosis of renal and retroperitoneal masses, particularly in women over the age 40, on the left side and in the absence of haematuria. Core needle biopsy should be performed. Patients should be managed by sarcoma multidisciplinary team. LRV should be surgically removed, with negative margins.
Ključne besede: leiomysarcoma, renal vein, surgery, outcomes, prognostic factors
Objavljeno v DiRROS: 24.05.2024; Ogledov: 161; Prenosov: 145
.pdf Celotno besedilo (458,38 KB)
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Prognostic factors of choroidal melanoma in Slovenia, 1986-2008
Boris Jančar, Marjan Budihna, Brigita Drnovšek-Olup, Katrina Novak-Andrejčič, Irena-Hedvika Brovet-Zupančič, Dušica Pahor, 2016, izvirni znanstveni članek

Povzetek: Introduction. Choroidal melanoma is the most common primary malignancy of the eye, which frequently metastasizes. The Cancer Registry of Slovenia reported the incidence of choroid melanoma from 1983 to 2009 as stable, at 7.8 cases/million for men and 7.4/million for women. The aim of the retrospective study was to determinate the prognostic factors of survival for choroidal melanoma patients in Slovenia. Patients and methods. From January 1986 to December 2008 we treated 288 patients with malignant choroidal melanoma; 127 patients were treated by brachytherapy with beta rays emitting ruthenium-106 applicators; 161 patients were treated by enucleation. Results. Patients with tumours thickness < 7.2 mm and base diameter < 16 mm were treated by brachytherapy and had 5- and 10-year overall mortality 13% and 32%, respectively. In enucleated patients, 5- and 10-year mortality was higher, 46% and 69%, respectively, because their tumours were larger. Thirty patients treated by brachytherapy developed local recurrence. Twenty five of 127 patients treated by brachytherapy and 86 of 161 enucleated patients developed distant metastases. Patients of age >/= 60 years had significantly lower survival in both treatment modalities. For patients treated by brachytherapy the diameter of the tumour base and treatment time were independent prognostic factors for overall survival, for patients treated by enucleation age and histological type of tumour were independent prognosticators. In first few years after either of treatments, the melanoma specific annual mortality rate increased, especially in older patients, and then slowly decreased. Conclusions. It seems that particularly younger patients with early tumours can be cured, whereby preference should be given to eyesight preserving brachytherapy over enucleation.
Ključne besede: choroidal melanoma, therapy, brachytherapy, prognostic factors
Objavljeno v DiRROS: 09.05.2024; Ogledov: 172; Prenosov: 107
.pdf Celotno besedilo (624,05 KB)
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Release of growth factors after mechanical and chemical pleurodesis for treatment of malignant pleural effusion : a randomized control study
Aljaž Hojski, Maja Leitgeb, Anton Crnjac, 2015, izvirni znanstveni članek

Povzetek: Growth factors are key inducers of fibrosis but can also mediate inflammatory responses resulting in increasing pleural effusion and acute respiratory distress syndrome. The primary aim of the study was to analyse growth factors release after performing chemical and mechanical pleurodesis in the first 48 hours at the patients with malignant pleural effusion. The secondary endpoints were to evaluate the effectiveness of the both pleurodeses, symptoms release and the quality of life of patients after the treatment. Patients and methods. A prospective randomized study included 36 consecutive female patients with breast carcinoma and malignant pleural effusion in an intention-to-treat analysis. We treated 18 patients by means of thoracoscopic mechanical pleurodesis and 18 patients by chemical pleurodesis with talcum applied over a chest tube. We gathered the pleural fluid and serum samples in the following 48 hours under a dedicated protocol and tested them for growth factors levels. A quality of life and visual analogue pain score surveys were also performed. Results. Median measured serum vascular endothelial growth factor (VEGF) level after chemical pleurodesis was 930.68 pg/ml (95% CI: 388.22-4656.65) and after mechanical pleurodesis 808.54 pg/ml. (95% CI: 463.20-1235.13) (p = 0.103). Median pleural levels of transforming growth factor (TGF) ß1 were higher after performing mechanical pleurodesis (4814.00 pg/ml [95% CI: 2726.51-7292.94]) when compared to those after performing chemical pleurodesis (1976.50 pg/ml [95% CI: 1659.82-5136.26]) (p = 0.078). We observed similar results for fibroblast growth factor (FGF) ß; the serum level was higher after mechanical pleurodesis (30.45 pg/ml [95% CI: 20.40-59.42]), compared to those after chemical pleurodesis (13.39 pg/ml [95% CI: 5.04-74.60]) (p = 0.076). Mechanical pleurodesis was equally effective as chemical pleurodesis in terms of hospital stay, pleural effusion re-accumulation, requiring of additional thoracentesis, median overall survival, but, it shortened the mean thoracic drainage duration (p = 0.030) and resulted in a higher symptoms release and in a better quality of life (p = 0.047). Conclusions. We recorded an increase in serum VEGF levels after chemical pleurodesis, however on the contrary, an increase in the pleural fluid level of TGF%1 and FGF%] after mechanical pleurodesis with respect to compared group. Although the differences did not reach statistical significance, VEGF, TGFß1 and FGFß remain the most interesting parameters for future research. Considering the mechanisms of growth factors action, we conclude that in our study group mechanical pleurodesis might be more efficient in terms of growth factors release, thoracic drainage duration and resulted in a higher symptoms release and in a better quality of life than chemical pleurodesis.
Ključne besede: malignant pleural effusion, pleurodesis, growth factors, quality of life
Objavljeno v DiRROS: 23.04.2024; Ogledov: 255; Prenosov: 256
.pdf Celotno besedilo (663,37 KB)
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Effects of governmental data governance on urban fire risk : a city-wide analysis in China
Zhao-Ge Liu, Xiang-Yang Li, Grunde Jomaas, 2022, izvirni znanstveni članek

Povzetek: The effects of data governance (as a means to maximize big data value creation in fire risk management) performance on fire risk was analyzed based on multi-source statistical data of 105 cities in China from 2016 to 2018. Specifically, data governance was first quantified with ten detailed indicators, which were then selected for explaining urban fire risk through correlation analysis. Next, the sample cities were clustered in terms of major socio-economic characteristics, and then the effects of data governance were examined by constructing multivariate regression models for each city cluster with ordinary least squares (OLS). The results showed that the constructed regression models produced good interpretation of fire risk in different types of cities, with coefficient of determination (R2) in each model exceeding 0.65. Among the indicators, the development of infrastructures (e.g. data collection devices and data analysis platforms), the level of data use, and the updating of fire risk related data were proved to produce significant effects on the reduction of fire frequency and fire consequence. Moreover, the organizational maturity of data governance was proved to be helpful in reducing fire frequency. For the cities with large population, the cross-department sharing of high-value data was found to be another important determinant of urban fire frequency. In comparison with existing statistical models which interpreted fire risk with general social factors (with the highest R2 = 0.60), these new regression models presented a better statistical performance (with the average R2 = 0.72). These findings are expected to provide decision support for the local governments of China and other jurisdictions to facilitate big data projects in improving fire risk management.
Ključne besede: urban fire risk, fire risk management, big data technologies, data governance, socio-economic factors, city-wide analysis
Objavljeno v DiRROS: 09.01.2024; Ogledov: 245; Prenosov: 53
.pdf Celotno besedilo (1,20 MB)
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Engineered combinatorial cell device for wound healing and bone regeneration
Lucija Kadunc, Duško Lainšček, Rok Gašperšič, Petra Sušjan, Uroš Kovačič, Miha Butinar, Boris Turk, Roman Jerala, Iva Hafner Bratkovič, 2023, izvirni znanstveni članek

Povzetek: Growth factors are the key regulators that promote tissue regeneration and healing processes. While the effects of individual growth factors are well documented, a combination of multiple secreted growth factors underlies stem cell–mediated regeneration. To avoid the potential dangers and laborintensive individual approach of stem cell therapy while maintaining their regeneration-promoting effects based on multiple secreted growth factors, we engineered a “mix-and-match” combinatorial platform based on a library of cell lines producing growth factors. Treatment with a combination of growth factors secreted by engineered mammalian cells was more efficient than with individual growth factors or even stem cell–conditioned medium in a gap closure assay. Furthermore, we implemented in a mouse model a device for allogenic cell therapy for an in situ production of growth factors, where it improved cutaneous wound healing. Augmented bone regeneration was achieved on calvarial bone defects in rats treated with a cell device secreting IGF, FGF, PDGF, TGF-β, and VEGF. In both in vivo models, the systemic concentration of secreted factors was negligible, demonstrating the local effect of the regeneration device. Finally, we introduced a genetic switch that enables temporal control over combinations of trophic factors released at different stages of regeneration mimicking the maturation of natural wound healing to improve therapy and prevent scar formation.
Ključne besede: wound healing, bone regeneration, growth factors
Objavljeno v DiRROS: 01.06.2023; Ogledov: 574; Prenosov: 225
.pdf Celotno besedilo (2,59 MB)
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Biological factors of the tumour response to electrochemotherapy : review of the evidence and a research roadmap
Gregor Serša, Katja Uršič Valentinuzzi, Maja Čemažar, Richard Heller, Maša Omerzel, Luca Giovanni Campana, 2021, pregledni znanstveni članek

Povzetek: The beneficial effects of electrochemotherapy (ECT) for superficial tumours and, more recently, deepseated malignancies in terms of local control and quality of life are widely accepted. However, the variability in responses across histotypes needs to be explored. Currently, patient selection for ECT is based on clinical factors (tumour size, histotype, and exposure to previous oncological treatments), whereas there are no biomarkers to predict the response to treatment. In this field, two major areas of investigation can be identified, i.e., tumour cell characteristics and the tumour microenvironment (vasculature, extracellular matrix, and immune infiltrate). For each of these areas, we describe the current knowledge and discuss how to foster further investigation. This review aims to provide a summary of the currently used guiding clinical factors and delineates a research roadmap for future studies to identify putative biomarkers of response to ECT. These biomarkers may allow researchers to improve ECT practice by customising treatment parameters, manipulating the tumour and its microenvironment, and exploring novel therapeutic combinations.
Ključne besede: biological factors, biomarkers, electrochemotherapy, bleomycin, cisplatin
Objavljeno v DiRROS: 23.09.2022; Ogledov: 607; Prenosov: 186
.pdf Celotno besedilo (1,32 MB)

Risk factors for systemic reactions in typical cold urticaria : results from the COLD-CE study
Mojca Bizjak, Mitja Košnik, Dejan Dinevski, Simon Francis Thomsen, Daria Fomina, Elena Borzova, Kanokvalai Kulthanan, Raisa Meshkova, Dalia Melina Ahsan, Mona Al-Ahmad, Jovan Miljković, Dorothea Terhorst, Marcus Maurer, 2022, izvirni znanstveni članek

Povzetek: Background. Cold urticaria (ColdU), i.e. the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU. Methods. An international, cross-sectional study COLD-CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold-induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms. Results. Of 551 ColdU patients, 75% (n=412) had a positive CST and ColdA occurred in 37% (n=151) of the latter. Cold-induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n=40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs 39%, p=0.003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes. Conclusion. ColdA is common in typical ColdU. High-risk patients require education about their condition and how to use an adrenaline autoinjector.
Ključne besede: urticaria, risk factors, epinephrine - therapeutic use, self administration, intramuscular injections - methods, cold urticaria, systemic reactions, adrenaline autoinjector
Objavljeno v DiRROS: 31.08.2022; Ogledov: 633; Prenosov: 249
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Post-harvest forest herb layer demography : general patterns are driven by pre-disturbance conditions
Janez Kermavnar, Klemen Eler, Aleksander Marinšek, Lado Kutnar, 2021, izvirni znanstveni članek

Povzetek: Timber harvesting constitutes extensive anthropogenic disturbance in temperate forests, producing a broad range of ecological impacts that most often enhance the demographic processes of vegetation. This study monitored post-harvest herb layer demography over a 6-year period in mesic Dinaric fir-beech forests (Slovenia), a vascular plant diversity hotspot among European forests. Three experimental harvesting intensities, i.e. full harvest (FH), partial harvest (PH) and a control treatment (NH), were each applied over a circular area of 4000 m2 and replicated three times at each of three study sites. Vegetation sampling was conducted before harvesting (in 2012), and two (2014) and six (2018) years following it, in a 400 m2 circular plot positioned in the centre of each treatment area. We focused on identifying general demographic patterns and evaluating the effects of various pre-disturbance abiotic and biotic predictors on compositional responses to disturbance. Two years after harvest (2012-2014), compositional shifts were larger than those in the next 4-year period (2014-2018), confirming the general theoretical prediction that species turnover rate decreases along a successional gradient. The degree of compositional shifts in gaps (FH) and thinned stands (PH) was affected by local abiotic factors (geomorphology of karst sinkholes) and community attributes, such as pre-harvest species richness. Our results indicate that compositional stability is positively associated with pre-disturbance species richness. Over the whole study period, increases in plot-level species richness (alpha diversity) and overall enrichment of the species pool (gamma diversity) were accompanied by compositional convergence, i.e. a decline in floristic dissimilarity (beta diversity) between and within study sites. However, the observed tendency towards homogenization was rather weak and would have been even more pronounced if the demographic type of persistent resident species had not shown a high degree of resistance, thus leaving a strong imprint on post-harvest vegetation development by preserving the forest characteristics of the herb layer community.
Ključne besede: forest succession, demographic types, community assembly, pre-disturbance factors, floristic convergence, fir-beech forests
Objavljeno v DiRROS: 22.07.2022; Ogledov: 569; Prenosov: 354
.pdf Celotno besedilo (1,91 MB)
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Natural history of the hymenoptera venom sensitivity reactions in adults : study design
Simona Perčič, Lidija Bojanić, Mitja Košnik, Andreja Kukec, 2022, izvirni znanstveni članek

Povzetek: Background: Allergic reactions to Hymenoptera stings can have varying levels of severity, according to the Müller grading system. Methods: By an epidemiological concept, this is a retrospective cohort study. The observed cohort was represented by patients referred to the University Clinic Golnik due to Hymenoptera allergic reaction in the period from 1997 to 2015. From the immunological database of the University Clinic Golnik, we obtained laboratory data (sIgE, skin tests and basophil activation test). The clinical characteristics of patients were obtained from BIRPIS. With the help of a questionnaire, which was sent to each patient in the period from May 2019 to April 2021, we obtained epidemiological data. For the assessment of the association between the severity of allergic reaction for the observed outcome, the severity of the first allergic reaction after Hymenoptera sting was used. Other variables were grouped according to risk factors. Discussion: We will identify the risk factors that could play an important role in a severe systemic reaction: the aetiology of the Hymenoptera sting, sex, age, history and severity of previous systemic reactions, being re-stung in an interval of two months, the frequency of re-stings, atopy, genetic predisposition, preventive medication use, other medication use, beekeeping or living next to beehives and why immunotherapy was not taken. Laboratory data will also be analysed to determine if there is any association with laboratory tests and the severity of the allergic reactions after Hymenoptera stings. Conclusions: Several new approaches are introduced in the study design. The most important is that the protocol covers epidemiological data gained from the questionnaire, as well as clinical data gained from the Immunological database and BIRPIS database. We expect to obtain significant results that will explain the risk factors for the natural history of Hymenoptera sting allergic reactions and will help allergologists, as well as general doctors, when facing those patients allergic to Hymenoptera venom without immunotherapy.
Ključne besede: hymenoptera venom allergy, risk factors, epidemiological association
Objavljeno v DiRROS: 06.04.2022; Ogledov: 895; Prenosov: 381
.pdf Celotno besedilo (786,63 KB)

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