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Povzetek: Objectives: This study assessed the effectiveness of prehydrated collagenated xenogenic bone gel and a collagenated cortico-cancellous heterologous bone mixture in conjunction with papillae tunneling techniques (PTT) for treating isolated periodontal intraosseous defects. Materials and methods: Twenty patients with periodontitis stage III/IV and at least one deep isolated interdental 2/3-wall intraosseous defect were included in the study. Surgical incisions were made vertically at the adjacent tooth or horizontally at the mucogingival junction. A full-thickness flap was then carefully lifted under the papillae using special tunneling instruments. The root surfaces were completely cleaned, and the defects were randomly filled with either prehydrated collagenated bone gel (test group; n = 10) or collagenated cortico-cancellous heterologous bone mixture (control group; n = 10). Wounds were closed with microsurgical sutures. We predicted that the lower 95% confidence interval for the difference between the two procedures would exceed a prespecified noninferiority threshold. Results: All wounds closed sufficiently to prevent biomaterial exposure. The test and control groups showed similar mean pocket depth reduction (3.5 ± 1.0 vs. 3.9 ± 1.7 mm; p = 0.52), similar gingival recession (-0.10 ± 0.99 vs. 0.2 ± 0.8 mm; p = 0.46), and similar clinical attachment gain (3.6 ± 1.51 vs. 3.7 ± 1.8 mm; p = 0.89) at the 12-month follow-up. All results were below the noninferiority margin of the sample. Conclusions: At 12 months, prehydrated collagenous bone gel performed similarly to collagenous heterologous bone granules in the treatment of intraosseous lesions with PTT. In addition, both biomaterials preserved soft tissue with minimal further recession at 1 year. Clinical relevance: When combined with PTT, collagenous xenogeneic bone granules and prehydrated collagenous bone gel achieve comparable clinical outcomes in intrabony defects. The study was registered under the NCT04782921 on ClinicalTrails.
Ključne besede: dual-phase xenogenic bone graft, intrabony defect, papillae preservation, periodontitis
Objavljeno v DiRROS: 05.06.2026; Ogledov: 163; Prenosov: 169
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Povzetek: Background: Selecting the most suitable skeletal remains for genetic analysis is challenging due to the variable DNA yield across different bone types and within individual bones. Compact bone typically preserves DNA longer, whereas cancellous bones, such as those in the hands and feet, often contain higher DNA quantities. This study aimed to incorporate dual-source computed tomography (DSCT), a technique frequently utilized for assessing bone density in living subjects, into targeted DNA sampling for dry, skeletonized remains by mapping compact and cancellous regions within six small skeletal elements. Materials and methods: A total of 137 bones were analysed using an imaging protocol specifically adapted to highlight the skeletal structure of small bones. This tailored protocol involved meticulous calibration of imaging parameters. Anatomical landmarks for six distinct elements were identified, and regions of interest were selected for bone density measurement in Hounsfield units (HU). Results: Among 461 assessed regions, 312 (68%) were classified as compact bone, and 149 (32%) as cancellous bone. Given the abnormal distribution of data, statistical differences were evaluated using 95% confidence intervals, with significance indicated by non-overlapping intervals. The analysis revealed statistically significant differences between compact and cancellous bone, as well as within each type across different bones. Conclusions: DSCT proved effective in mapping the internal structure of six small skeletal elements in dry, skeletonized remains, underscoring significant intra-bone variability in density. The findings illustrate DSCT's substantial potential for enhancing DNA sampling in forensic and paleogenetic studies, setting the stage for future research advancements.
Ključne besede: intro-bone variability, compact and concellous bone, dual-source CT, short and sesamoid bones, bone density
Objavljeno v DiRROS: 20.04.2026; Ogledov: 203; Prenosov: 221
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Povzetek: The current study aims to improve clarithromycin bioavailability and effectiveness in complicated intra-abdominal infection management. Therefore, clarithromycin-loaded submicron dual lipid carriers (CLA-DLCs) were developed via hot high shear homogenization technique and evaluated for colloidal parameters, release behavior, stability study, and in-vitro antibiofilm activity. Bioavailability and therapeutic efficacy of optimized formulation on hampering cytokines storm induction was determined in E. coli-induced peritonitis. The developed CLA-DLCs (particle size 326.19 ± 24.14 nm, zeta potential −31.34 ± 2.81 mV, and entrapment efficiency 85.78 ± 4.01%) exhibited smooth spherical shapes and sustained in vitro release profiles. Long-term stability study of optimized CLA-DLCs ensured maintenance of colloidal parameters for 1 year at room temperature. In vitro antimicrobial studies revealed 3.43-fold higher anti-biofilm activity of CLA-DLCs compared with clarithromycin. In addition, the relative bioavailability of CLA-DLCs was enhanced 5.89-fold compared to pure drug in rats. The remarkable decrease in microbial burden in blood as well as tissues, along with oxidative stress markers (lipid peroxidation, myeloperoxidase activity, and carbonylated protein level) and immunological markers (total leukocyte count, neutrophil migration, NO, TNF-, and IL-6) on treatment with CLA-DLCs enhanced the survival in a rat model of peritonitis compared with the pure drug and untreated groups. In conclusion, CLA-DLCs hold promising potential in management of intra-abdominal infections and prevention of associated complications.
Ključne besede: clarithromycin, E. coli, peritonitis, submicron dual lipid carriers
Objavljeno v DiRROS: 16.12.2025; Ogledov: 570; Prenosov: 324
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Povzetek: Outer, dual, and total general position sets are studied on strong and lexicographic products of graphs. Sharp lower and upper bounds are proved for the outer and the dual general position number of strong products and several exact values are obtained. For the lexicographic product, the outer general position number is determined in all the cases, and the dual general position number is established in many cases. The total general position number is determined for both products. Along the way some results on outer general position sets are also derived.
Ključne besede: outer general position, dual general position, total general position, strong product, lexicographic product
Objavljeno v DiRROS: 15.12.2025; Ogledov: 960; Prenosov: 261
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Povzetek: People with Parkinson’s Disease (PD) often compensate for impaired automatic balance control by engaging additional attentional resources for motor tasks. With disease progression, their cognitive system too becomes increasingly affected, further impairing postural stability. The interaction between cognitive and motor systems in the early disease stages, however, remains poorly investigated. The present study aimed to elucidate behavioral and neurophysiological changes in early-stage PD to identify with greater accuracy the specific disease-related discrepancies from healthy functioning on both cognitive and motor systems. Eighteen participants with PD (aged 62.9±6.6 years) and 18 healthy matched controls (aged 62.9±6.4 years) performed (i) a balancing single task in a semi-tandem stance (ST-sts), (ii) a single visual oddball task with conflicting Stroop color-word stimuli (ST-Stroop), and (iii) a dual-task (DT) combining the two single tasks. Centre of pressure displacement using a force plate and 128-channel electroencephalography (EEG) were recorded. Participants with PD exhibited reduced postural sway compared to controls, and postural sway was lower in DT as opposed to ST. Reduced sway in PD might be attributed to postural rigidity and tonic muscle activation, while in the DT, it might reflect resource conflicts. EEG analyses indicated distinct spectral activity patterns: the central midline low-frequency (δ, θ) power increased with cognitive load, centroparietal β desynchronization intensified with motor load, and parietal α desynchronization heightened during DT in both PD and control groups, underscoring specific frequency bands’ governing roles in cognitivemotor processing. Furthermore, PD participants exhibited heightened or prolonged responses in ERP components related to working memory (frontocentral P2) and conflict resolution (P300), possibly reflecting compensatory neural strategies. Overall, these findings suggest that cognitive capacities, particularly selective attention, might be more affected than sensory acuity in early PD, highlighting areas for targeted interventions.
Ključne besede: EEG, semi-tandem stance, COP (Center of pressure), Parkinson's disease, cognitive-motor dual-tasking
Objavljeno v DiRROS: 08.09.2025; Ogledov: 633; Prenosov: 421
Celotno besedilo (4,02 MB)
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