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Povzetek: Introduction: Psychological distress is common in psoriasis, but its prevalence and possible biological correlates in young adults with well-controlled disease remain unclear. In this study, we aimed to assess the presence of anxiety and depressive symptoms in young, well-treated psoriasis patients, who were primarily expected to have no or minimal psychological distress, and to explore potential associations with inflammatory and metabolic markers. Methods: In a cross-sectional cohort of 80 psoriasis patients (women/male: 45/35; mean age 38.7 ± 4.2 years) psychological symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS), with HADS-A and HADS-D subscales evaluating anxiety and depression symptoms. Exploratory associations with inflammatory cytokines and metabolic indices were examined using regression analyses and random forest machine-learning models. Results: Anxiety symptoms were identified only in 5 patients (women/male: 4/1; 6%), and depressive symptoms in 10 patients (women/male: 6/4; 12%). Affected individuals had clinically significant anxiety (HADS-A: 12/21) and borderline depressive symptoms (HADS-D: 10/21). No significant associations between HADS scores and inflammatory or metabolic markers were found. Exploratory random forest models tentatively identified IL-6, IL-23, FIB-4, HOMA-IR, and waist circumference as the strongest contributors to variance in depressive symptoms, while no clear contributors emerged for anxiety. Discussion: Anxiety and depressive symptoms can occur in well-treated young psoriasis patients. Although prevalence is low, their impact may be substantial. These findings indicate the potential importance of targeted psychological screening in this population. Associations with inflammatory and metabolic markers should be considered hypothesis-generating and warrant validation in larger, independent cohorts.
Ključne besede: psoriasis, HADS, depression, anxiety, treatment, young patients
Objavljeno v DiRROS: 14.01.2026; Ogledov: 51; Prenosov: 17
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Povzetek: Background and aims: Coronary artery disease (CAD) is a leading cause of mortality. Depression and anxiety are common in CAD patients and negatively affect quality of life, physical functioning, and adherence to cardiac rehabilitation (CR) programs. This study aimed to identify possible associations with clinically relevant parameters, vascular function and blood biomarkers. Methods: Participants were consecutively recruited during cardiac rehabilitation intake visits at the University Medical Centre Ljubljana within 4 months of myocardial infarction (MI). Hospital Anxiety and Depression Scale (HADS) scores were analyzed in relation to endothelial function (assessed with flow-mediated dilation), arterial stiffness, and blood biomarkers (fibrinogen, endocan, and brain-derived neurotrophic factor [BDNF]) in post-MI patients. All vascular and biomarker assessments were performed within 5 days of questionnaire completion and prior to the start of rehabilitation. Results: There were 105 patients included in the study. The median age was 56 years (49–62), and 80.0% of participants were male. Clinically relevant anxiety and depression were present in 29.5% and 21.9% of participants, respectively. Anxiety was significantly associated with younger age, higher body mass index, and increased arterial stiffness, with total HADS scores negatively correlated with age. Endothelial function showed no significant associations with HADS scores. Vital signs showed no significant differences, except for slightly higher systolic blood pressure in those with clinically relevant depression. Fibrinogen levels were significantly higher in participants with anxiety and depression, while endocan and BDNF levels were lower in those with anxiety. Conclusion: Depression and especially anxiety are significantly associated with endothelial function and relevant biomarkers in post-MI patients. However, as HADS is a screening tool and not a diagnostic instrument, and given the study’s observational design, findings reflect associations rather than causality. Routine screening and targeted mental health support within CR programs might improve participation, enhance cardiovascular recovery, and optimize long-term outcomes. These findings underscore the clinical importance of psychological assessment in the early post-MI period and support the integration of mental health evaluation into cardiovascular care.
Ključne besede: anxiety, depression, cardiac rehabilitation, coronary artery disease, myocardial infarction, pulse-wave velocity, endothelial dysfunction
Objavljeno v DiRROS: 24.11.2025; Ogledov: 243; Prenosov: 116
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Povzetek: The present article examines the contribution to the problem of nihilism found in the American philosopher and psychologist William James, specifically in his essay “Is Life Worth Living?” from 1896 and the chapter “The Sick Soul” from his The Varieties of Religious Experience from 1902. At the age of 27, James suffered a period of intense depression that lasted from the fall of 1869 until the spring of 1870. This experience shaped his views on nihilism. The present article argues that James’s proposed solution to the problem of nihilism, although formulated rather differently, is in essence the same as that of Jean Paul and the Danish thinker Poul Martin Møller. James’s originality can be found in his treatment of the issue as a psychological problem.
Ključne besede: nihilism, psychology of religion, depression, meaninglessness, despair
Objavljeno v DiRROS: 09.01.2025; Ogledov: 526; Prenosov: 282
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Ključne besede: depression, anxiety, prevalence, female football players, adolescence
Objavljeno v DiRROS: 12.09.2022; Ogledov: 1385; Prenosov: 1087
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Povzetek: Although recognised as effective measures to curb the spread of the COVID-19 outbreak, social distancing and self-isolation have been suggested to generate a burden throughout the population. To provide scientific data to help identify risk factors for the psychosocial strain during the COVID-19 outbreak, an international cross-disciplinary online survey was circulated in April 2020. This report outlines the mental, emotional and behavioural consequences of COVID-19 home confinement. The ECLB-COVID19 electronic survey was designed by a steering group of multidisciplinary scientists, following a structured review of the literature. The survey was uploaded and shared on the Google online survey platform and was promoted by thirty-five research organizations from Europe, North Africa, Western Asia and the Americas. Questions were presented in a differential format with questions related to responses %before% and %during% the confinement period. 1047 replies (54% women) from Western Asia (36%), North Africa (40%), Europe (21%) and other continents (3%) were analysed. The COVID-19 home confinement evoked a negative effect on mental wellbeing and emotional status (P < 0.001; 0.43 % d % 0.65) with a greater proportion of individuals experiencing psychosocial and emotional disorders (+10% to +16.5%). These psychosocial tolls were associated with unhealthy lifestyle behaviours with a greater proportion of individuals experiencing (i) physical (+15.2%) and social (+71.2%) inactivity, (ii) poor sleep quality (+12.8%), (iii) unhealthy diet behaviours (+10%), and (iv) unemployment (6%). Conversely, participants demonstrated a greater use (+15%) of technology during the confinement period. These findings elucidate the risk of psychosocial strain during the COVID-19 home confinement period and provide a clear remit for the urgent implementation of technology-based intervention to foster an Active and Healthy Confinement Lifestyle AHCL).
Ključne besede: coronavirus, COVID-19, pandemic, public health, restrictions, isolation, home confinement, psychosocial health, mental wellbeing, depression, satisfaction, lifestyle, behaviours
Objavljeno v DiRROS: 18.12.2020; Ogledov: 2706; Prenosov: 1460
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