1. Mental health service preparedness during a pandemic : A Delphi study in SloveniaŠpela Selak, Nuša Crnkovič, Janja Horvat, Irena Makivić, 2026, izvirni znanstveni članek Povzetek: Introduction The COVID-19 pandemic posed significant challenges for mental health, requiring many mental health services to reorganise. The aim of this study was to develop a set of consensus-based recommendations outlining measures and activities for the operation of mental health services during a potential pandemic in Slovenia. Methods To develop a preliminary list of measures, relevant literature, existing guidelines, and COVID-19 response practices were reviewed. These measures were then evaluated using a modified Delphi method. Eleven Slovenian mental health experts participated in 4 Delphi rounds to determine which measures should be implemented and at which stage of a potential future pandemic. Results Consensus was reached on 47 measures and activities. The majority were classified for implementation before or at the onset of a potential pandemic, with only a small number designated for implementation during the pandemic. Conclusions The identified measures and activities are discussed in relation to existing research and international frameworks. They represent consensus-based preparedness guidance for the organisation of mental health services during a pandemic or similar public health emergency and may inform the future development of national guidelines and strategic frameworks.
Ključne besede: mental health services, pandemic preparedness, Delphi consensus, health system resilience
Objavljeno v DiRROS: 11.06.2026; Ogledov: 276; Prenosov: 188
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2. ESTES recommendations for the treatment of polytrauma-a European consensus based on the German S3 guidelines for the treatment of patients with severe/multiple injuriesCristina Rey Valcarcel, Dan Bieler, Gary A. Bass, Christine Gaarder, Frank Hildebrand, 2025, izvirni znanstveni članek Povzetek: Introduction: Considerable heterogeneity exists in the configuration and implementation maturity of trauma systems across European healthcare settings, and the opportunities for guideline-informed high-quality care varies considerably. Therefore, the European Society of Trauma and Emergency Surgery (ESTES), with its constituent national societies, has developed comprehensive consensus recommendations for care-context appropriate treatment of polytrauma patients in Europe, from the pre-hospital setting to the first surgical phase. Methods: Adhering to the RAND/UCLA Appropriateness Method (RAM), ESTES conducted a three-round modified Delphi consensus. National society expert delegates assessed Grade of Recommendation (GoR) A and Good Clinical Practice Points (GPP) elements of the German Society of Trauma Surgery (DGU) “S3 guidelines for polytrauma/severe injury management” for appropriateness and implementability within their respective healthcare systems. Results: In the first consensus round, 82 GoR A and 57 GPP recommendations were analysed. Of these, seven GPP were rephrased for clarity and four were removed due to redundancy or conflicting content. Consequently, 135 recommendations (82 GoR A and 53 GPP) remained, with 128 (77 GoR A and 51 GPP) deemed appropriate and necessary, and seven as uncertain due to expert disagreement. Conclusion: These ESTES recommendations constitute the first cohesive Europe-wide framework for managing the polytrauma patient from the prehospital setting to the end of the first surgical phase. They serve as a foundational tool for the development of national guidelines, particularly in regions with evolving trauma systems, and promote alignment towards a uniform standard-of-care across Europe.
Ključne besede: polytrauma, injury, guidelines, recommendations, consensus
Objavljeno v DiRROS: 20.05.2026; Ogledov: 369; Prenosov: 205
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3. Placenta-oriented counseling : challenges and opportunities in obstetric practicePolona Pečlin, 2026, pregledni znanstveni članek Povzetek: Placental histopathology is an invaluable yet underutilized resource in obstetric care. While it offers unique insights into the etiology of adverse pregnancy outcomes, its clinical integration is often limited by inconsistencies in placenta submission, reporting delays, lack of standardized interpretation, and limited interdisciplinary dialogue. Certain placental abnormalities provide immediate clinical insights, guiding acute management decisions, while others indicate an increased risk of recurrence in future pregnancies. Additionally, many lesions help contextualize antenatal findings or clarify postnatal complications, offering valuable diagnostic and prognostic information. The article reviews the spectrum of placental lesions, ranging from common findings to rare high-risk entities, and their implications for future pregnancy outcomes. It examines both the persistent challenges and emerging opportunities associated with placenta-oriented counseling in modern obstetric practice. It also explores strategies for translating placental findings into actionable care, emphasizing the importance of implementing structured, multidisciplinary review processes. Furthermore, it highlights how placental histologic findings must be interpreted within the broader clinical context, considering maternal history, laboratory investigations, microbiological cultures, genetic analyses, and neonatal outcomes, to ensure their diagnostic relevance and support informed patient-centered decision-making focused on the maternal–placental–fetal triad.
Ključne besede: placenta, histology, Amsterdam consensus, stillbirth, preeclampsia, fetal growth restriction
Objavljeno v DiRROS: 18.03.2026; Ogledov: 384; Prenosov: 248
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4. The use of continuous glucose monitoring in people living with obesity, intermediate hyperglycemia or type 2 diabetesTadej Battelino, Nebojsa M. Lalić, Sufyan Hussain, Antonio Ceriello, Sanja Klobučar, Sarah J Davies, Pinar Topsever, Julie Heverly, Francesca Ulivi, 2025, pregledni znanstveni članek Povzetek: A global trend towards increased obesity, intermediate hyperglycemia (previously termed prediabetes) and type 2 diabetes, has prompted a range of international initiatives to proactively raise awareness and provide action-driven recommendations to prevent and manage these linked disease states. One approach, that has shown success in managing people already diagnosed with type 2 diabetes mellitus, is to use continuous glucose monitoring (CGM) devices to help them manage their chronic condition through understanding and treating their daily glucose fluctuations, in assocation with glucose-lowering medications, including insulin. However, much of the burden of type 2 diabetes mellitus is founded in the delayed detection both of type 2 diabetes mellitus itself, and the intermediate hyperglycemia that precedes it. In this review, we provide evidence that using CGM technology in people at-risk of intermediate hyperglycemia or type 2 diabetes mellitus can significantly improve the rate and timing of detection of dysglycemia. Earlier detection allows intervention, including through continued use of CGM to guide changes to diet and lifestyle, that can delay or prevent harmful progression of early dysglycemia. Although further research is needed to fully understand the cost-effectiveness of this intervention in people at-risk or with early dysglycemia, the proposition for use of CGM technology is clear.
Ključne besede: continuous glucose monitoring, consensus statements, intermediate hyperglycemia, obesity, prediabetes
Objavljeno v DiRROS: 08.12.2025; Ogledov: 905; Prenosov: 428
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5. Current and innovative approaches in the treatment of non-muscle invasive bladder cancer : the role of transurethral resection of bladder tumor and organoidsMilena Taskovska, Mateja Erdani-Kreft, Tomaž Smrkolj, 2020, pregledni znanstveni članek Povzetek: Background. Bladder cancer is the 7th most common cancer in men. About 75% of all bladder cancer are nonmuscle invasive (NMIBC). The golden standard for definite diagnosis and first-line treatment of NMIBC is transurethral resection of bladder tumour (TURB). Historically, the monopolar current was used first, today bipolar current is preferred by most urologists. Following TURB, depending on the tumour grade, additional intravesical chemo- or/and immunotherapy is indicated, in order to prevent recurrence and need for surgical resection. Development of new technologies, molecular and cell biology, enabled scientists to develop organoids % systems of human cells that are cultivated in the laboratory and have characteristics of the tissue from which they were harvested. In the field of urologic cancers, the organoids are used mainly for studying the course of different diseases, however, in the field of bladder cancer the data are scarce. Conclusions. Different currents - monopolar and bipolar, have different effect on urothelium, that is important for oncological results and pathohistological interpretation. Specimens of bladder cancer can be used for preparation of organoids that are further used for studying carcinogenesis. Bladder organoids are step towards personalised medicine, especially for testing effectiveness of chemo-/immunotherapeutics.
Ključne besede: bladder cancer, transurethral resection of bladder tumour, monopolar/bipolar current, consensus molecular subtype
Objavljeno v DiRROS: 12.07.2024; Ogledov: 1205; Prenosov: 767
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6. Consensus molecular subtypes (CMS) in metastatic colorectal cancer : personalized medicine decisionMartina Reberšek, 2020, pregledni znanstveni članek Povzetek: Colorectal cancer (CRC) is one of the most common types of cancer in the world. Metastatic disease is still incurable in most of these patients, but the survival rate has improved by treatment with novel systemic chemotherapy and targeted therapy in combination with surgery. New knowledge of its complex heterogeneity in terms of genetics, epigenetics, transcriptomics and microenvironment, including prognostic and clinical characteristics, led to its classification into various molecular subtypes of metastatic CRC, called consensus molecular subtypes (CMS). The CMS classification thus enables the medical oncologists to adjust the treatment from case to case. They can determine which type of systemic chemotherapy or targeted therapy is best suited to a specific patient, what dosages are needed and in what order. Conclusions. CMS in metastatic CRC are the new tool to include the knowledge of molecular factors, tumour stroma and signalling pathways for personalized, patient-orientated systemic treatment in precision medicine.
Ključne besede: metastatic colorectal cancer, heterogeneity, biomarkers, consensus molecular subtype
Objavljeno v DiRROS: 12.07.2024; Ogledov: 1599; Prenosov: 415
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7. ILIVE Project Volunteer study. Developing international consensus for a European Core Curriculum for hospital end-of-life-care volunteer services, to train volunteers to support patients in the last weeks of life : a Delphi studyTamsin McGlinchey, Stephen Mason, Ruthmarijke Smeding, Anne Goosensen, Inmaculada Ruiz-Torreras, Dagny Renata Faksvåg Haugen, Miša Bakan, John Ellershaw, 2022, izvirni znanstveni članek Povzetek: Background: Volunteers make a huge contribution to the health and wellbeing of the population and can improve satisfaction with care especially in the hospice setting. However, palliative and end-of-life-care volunteer services in the hospital setting are relatively uncommon. The iLIVE Volunteer Study, one of eight work-packages within the iLIVE Project, was tasked with developing a European Core Curriculum for End-of-Life-Care Volunteers in hospital. Aim: Establish an international consensus on the content of a European Core Curriculum for hospital end-of-life-care volunteer services which support patients in the last weeks of life. Design: Delphi Process comprising the following three stages: 1. Scoping review of literature into palliative care volunteers. 2. Two rounds of Delphi Questionnaire. 3. Nominal Group Meeting. Setting/participants: Sixty-six participants completed the Round 1 Delphi questionnaire; 75% (50/66) took part in Round 2. Seventeen participants attended the Nominal Group Meeting representing an international and multi-professional group including, clinicians, researchers and volunteer coordinators from the participating countries. Results: The scoping review identified 88 items for the Delphi questionnaire. Items encompassed organisational issues for implementation and topics for volunteer training. Three items were combined and one item added in Round 2. Following the Nominal Group Meeting 53/87 items reached consensus. Conclusion: Key items for volunteer training were agreed alongside items for implementation to embed the end-of-life-care volunteer service within the hospital. Recommendations for further research included in-depth assessment of the implementation and experiences of end-of-life-care volunteer services. The developed European Core Curriculum can be adapted to fit local cultural and organisational contexts.
Ključne besede: palliative care, death, volunteers, hospitals, consensus, Delphi technique, end-of-life care, Delphi study, iLIVE project
Objavljeno v DiRROS: 13.09.2022; Ogledov: 1865; Prenosov: 824
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