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1.
Continuous glucose monitoring use and glucose variability in pre-school children with type 1 diabetes
Klemen Dovč, Kevin Cargnelutti, Anže Šturm, Julij Šelb, Nataša Bratina, Tadej Battelino, 2018

Povzetek: Aims. The objective of this nationwide population-based cohort study was to evaluate the correlation between continuous glucose monitoring (CGM) use and glucose variability in pre-schoolers with type 1 diabetes. Methods. We analysed data from the Slovenian National Registry. The primary endpoint was the difference in glucose variability between periods, during which participants were using CGM and periods, during which CGM was not used, over 5 years. Results. A total of 40 children <8 years old were followed for an estimated observational period of 116 patient/years. Mean age at CGM initiation was 3.5 (±1.7) years. Both standard deviation of mean glucose [3.6 mmol/L (3.2–3.9) with CGM and 4.3 mmol/L (3.8–4.7) without CGM, p < 0.001] and coefficient of variation [44.0% (40.4–47.0) with CGM and 46.1% (42.3–49.4) without CGM, p = 0.021] were lower during the periods, when CGM was used. Frequent CGM use (>5 days/week) was associated with a 0.4% [4.4 mmol/mol] reduction in glycated haemoglobin level (7.6% compared to 7.2%, p = 0.047). Conclusions. Our results indicate that the use of CGM was associated with reduced glucose variability during a 5 year follow-up period among pre-schoolers with type 1 diabetes.
Ključne besede: continuous glucose monitoring, type 1 diabetes, children, insulin therapy
DiRROS - Objavljeno: 12.11.2020; Ogledov: 483; Prenosov: 272
.pdf Celotno besedilo (738,73 KB)

2.
Hereditary angioedema due to C1-inhibitor deficiency in pediatric patients in Croatia : first national study, diagnostic and prophylactic challenges
Ljerka Karadža-Lapić, Marko Barešić, Renata Vrsalović, Irena Ivković-Jureković, Saša Sršen, Ingrid Prkačin, Matija Rijavec, Draško Cikojević, 2019

Povzetek: Hereditary angioedema (HAE) is a rare autosomal dominant disease with deficiency (type I) or dysfunction (type II) of C1 inhibitor, caused by mutations in the C1-INH gene, characterized by recurrent submucosal or subcutaneous edemas including skin swelling, abdominal pain and life-threatening episodes of upper airway obstruction. The aim of this study was to investigate healthcare experiences in children with HAE due to C1 inhibitor deficiency (C1-INH-HAE) in Croatia in order to estimate the number of affected children and to recommend management protocols for diagnosis, short-term prophylaxis and acute treatment. Patients were recruited during a 4-year period at five hospitals in Croatia. Complement testing was performed in patients with a positive family history. This pilot study revealed nine pediatric patients positive for C1-INH- HAE type I, aged 1-16 years, four of them asymptomatic. Before the age of one year, C1-INH levels may be lower than in adults; it is advisable to confirm C1-INH-HAE after the age of one year. Plasma-derived C1- INH is recommended as acute and short-term prophylactic treatment. Recombinant C1-INH and icatibant are licensed for the acute treatment of pediatric patients. In Croatia, HAE is still underdiagnosed in pediatric population.
Ključne besede: hereditary angioedemas -- genetics -- Croatia, inborn genetic diseases -- Croatia, pediatrics -- Croatia, C1 inhibitor, SERPING1 gene, children
DiRROS - Objavljeno: 16.12.2020; Ogledov: 486; Prenosov: 364
.pdf Celotno besedilo (477,81 KB)

3.
Additional exergames to regular tennis training improves cognitive-motor functions of children but may temporarily affect tennis technique : a single-blind randomized controlled trial
Luka Šlosar, Eling D. de Bruin, Eduardo Bodnariuc Fontes, Matej Plevnik, Rado Pišot, Boštjan Šimunič, Uroš Marušič, 2021

Povzetek: This study evaluated the effects of an exergame program (TennisVirtua-4, Playstation Kinect) combined with traditional tennis training on autonomic regulation, tennis technique, gross motor skills, clinical reaction time, and cognitive inhibitory control in children. Sixty-three children were randomized into four groups (1st % two exergame and two regular trainings sessions/week, 2nd % one exergame and one regular training sessions/week, 3rd % two regular trainings sessions/week, and 4th % one regular training session/week) and compared at baseline, 6-month immediately post intervention and at 1-year follow-up post intervention. At 6-month post intervention the combined exergame and regular training sessions revealed: higher breathing frequency, heart rate (all ps % 0.001) and lower skin conductance levels (p = 0.001) during exergaming; additional benefits in the point of contact and kinetic chain elements of the tennis forehand and backhand technique (all ps % 0.001); negative impact on the shot preparation and the follow-through elements (all ps % 0.017); higher ball skills (as part of the gross motor skills) (p < 0.001); higher percentages of clinical reaction time improvement (1st %9.7% vs 3rd group %7.4% and 2nd %6.6% vs 4th group %4.4%, all ps % 0.003) and cognitive inhibitory control improvement in both congruent (1st %20.5% vs 3rd group %18.4% and 2nd %11.5% vs 4th group %9.6%, all ps % 0.05) and incongruent (1st group %19.1% vs 3rd group %12.5% and 2nd group %11.4% vs 4th group %6.5%, all ps % 0.001) trials. The 1-year follow-up test showed no differences in the tennis technique, clinical reaction time and cognitive inhibitory control improvement between groups with the same number of trainings per week. The findings support exergaming as an additional training tool, aimed to improve important cognitive-motor tennis skills by adding dynamics to the standardized training process. Caution should be placed to planning this training, e.g., in a mesocycle, since exergaming might decrease the improvement of specific tennis technique parts of the trainees. (ClinicalTrials.gov; ID: NCT03946436).
Ključne besede: tennis, training, performance, children, motor learning, cognitive learning, teaching, strategies
DiRROS - Objavljeno: 17.03.2021; Ogledov: 386; Prenosov: 240
.pdf Celotno besedilo (1,81 MB)

4.
Physical activity drops during summer holidays for 6- to 9-year-old children
Tadeja Volmut, Rado Pišot, Jurij Planinšec, Boštjan Šimunič, 2021

Povzetek: Regular physical activity (PA) reduces the health risk of childhood obesity and associated chronic diseases as well as mental health problems. Since PA declines as children age as well with future generations it is of highest importance to intervene in school and out-of-school settings. Out-of-school periods affect children's PA as it is mainly left to the interest and motivation of their parents. We compared accelerometer-based PA patterns in 93 6- to 9-year old children assessed four times: before (May/June), during (August), and after (September) summer holidays and at a 1-year follow up (May/June). Before summer holidays children were assessed also for anthropometry and motor tests. During summer holidays overall PA decreased by 18% (p < 0.001), physical inactivity increased by 5.5% (p < 0.001), moderate PA decreased by 53% (p < 0.001) and moderate to vigorous PA decreased by 45% (p < 0.001) when compared to before summer holidays. Furthermore, overall PA remained diminished also after summer holidays by 8.8% (p = 0.001) but recovered to baseline values at 1-year follow up. About 30% of overall PA and moderate to vigorous PA decrease during summer holidays could be explained by children's fitness level as a greater decrease was found in children with better results in standing long jump and 300-meter running time. Our finding detects an alarming summer holiday decrease in children PA that should not be neglected in future studies and intervention designs.
Ključne besede: MVPA, children, vacations, physical inactivity, sedentary behavior, accelerometer
DiRROS - Objavljeno: 19.01.2021; Ogledov: 427; Prenosov: 344
.pdf Celotno besedilo (416,68 KB)

5.
Children's daily routine response to COVID-19 emergency measures in Serbia
Saša Pišot, Dragan Krivokapić, Nebojša Maksimović, Ivana Milovanović, Radenko Matić, Jovan Vuković, 2021

Povzetek: Objective: The emergence of coronavirus in Serbia as well as in other European countries led to the declaration of a state of emergency, which, among other measures, included a switch to online education, the lockdown of public life and organized sports, and a curfew from 5 pm to 5 am. This study aimed to investigate the extent to which these measures affected children%s daily routines. More specifically, it aimed to determine how children maintained their learning, physical activity, and screen time routines from the period before the state of emergency was declared. Methods: Response to an online parent-reported questionnaire was conducted (N = 450). The factorial validity of the scales was prepared using confirmatory factor analysis, with acceptable fit indices. Based on that, the authors tested the interrelations between dimensions using structural equation modeling in SPSS, AMOS 24.0. Results: The study results indicate a positive relationship between school achievement and study time (% = 0.25). They also indicate that children who were physically active before the pandemic continued their activities during the emergency state (% = 0.53). Physical activity impact during the COVID-19 emergency measures reduces children%s behavior changes (% = 0.55). Finally, they highlight that children who spent more time with multimedia content had greater changes in anxiety, sensitivity, nervousness, and worry due to COVID-19 emergency measures (% = %0.38). Conclusions: Healthy lifestyle habits formed in childhood are suggested to be responsible for the greater %resistance to change% shown by the children from this study.
Ključne besede: children, daily routine, school achievement, physical activity, coronavirus, COVID-19, pandemic, restrictions, emergency measures, Serbia
DiRROS - Objavljeno: 22.04.2021; Ogledov: 392; Prenosov: 220
.pdf Celotno besedilo (1,30 MB)

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