1. From awareness to action : building monitoring capacity for tobacco and nicotine industry interference—experience from the JA PreventNCD projectTaija Voutilainen, Zala Jeras, Helena Koprivnikar, Hanna Ollila, 2026, izvirni znanstveni članek Povzetek: Industry interference remains a major barrier to effective tobacco control. WHO Framework Convention on Tobacco Control (FCTC) Article 5.3 obliges Parties to protect public health policies from industry influence, yet systematic monitoring of interference is often lacking. The emergence of new nicotine products and actors further complicate implementation and monitoring. Within Joint Action PreventNCD, we assessed monitoring and information exchange practices related to tobacco and nicotine industry interference in five European countries (Belgium, Estonia, Finland, Iceland, and Slovenia). Partner organizations (n¼5) completed an online questionnaire (July–September 2024) and the responses were descriptively analysed. To supplement the questionnaire data, we continued and expanded the search for recent interference examples until January 2025, covering examples from 2019 to 2024 through a review of publicly available sources; these were categorized by known interference tactics. Although all partners acknowl edged the importance of monitoring, most countries lacked protocols, designated entities, or registries for industry interference. While some disclosure measures existed, such as policies requiring disclosure of meetings with indus try and potential conflicts of interest, comprehensive safeguards were rare. Interference examples underscored the need for stronger monitoring, as known interference tactics—lobbying, harm-reduction narratives, corporate social responsibility campaigns, and use of front groups—were consistently employed, particularly around regulatory blind spots and new nicotine products. Systematic monitoring of tobacco and nicotine industry interference is essential to safeguard public health policies under WHO FCTC Article 5.3. Building national capacity, fostering collaboration between governments and civil society, and using international benchmarking tools are important steps toward this goal.
Ključne besede: tobacco, nicotine industry, public health, law enforcement, tobacco control, tobak, industrija tobaka, kontrola, javno zdravje
Objavljeno v DiRROS: 05.08.2026; Ogledov: 229; Prenosov: 67
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2. Inflammatory, oxidative stress and small cellular particle response in HUVEC induced by debris from endoprosthesis processingZala Jeras, Matej Hočevar, Veno Kononenko, Sara Michelini, Neža Repar, Maja Caf, Boštjan Kocjančič, Drago Dolinar, Slavko Kralj, Darko Makovec, Aleš Iglič, Damjana Drobne, Monika Jenko, Veronika Kralj-Iglič, 2023, izvirni znanstveni članek Ključne besede: endoprosthesis failure, corundum, cytokines, reactive oxygen species, lipid droplets
Objavljeno v DiRROS: 02.02.2024; Ogledov: 2013; Prenosov: 1077
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3. Autologous platelet and extracellular vesicle-rich plasma as therapeutic fluid : a reviewKaja Troha, Domen Vozel, Matevž Arko, Apolonija Bedina Zavec, Drago Dolinar, Matej Hočevar, Zala Jeras, Matic Kisovec, Boštjan Kocjančič, Ljubiša Pađen, Manca Pajnič, Samo Penič, Anna Romolo, Neža Repar, Vesna Spasovski, Nejc Steiner, Vid Šuštar, Aleš Iglič, Damjana Drobne, Ksenija Kogej, Saba Battelino, Veronika Kralj-Iglič, 2023, pregledni znanstveni članek Ključne besede: platelet-rich plasma, platelets, centrifugation, extracellular vesicles, small cellular particles, wound healing, regeneration, fresh-frozen plasma, intercellular signaling peptides and proteins
Objavljeno v DiRROS: 26.01.2024; Ogledov: 1970; Prenosov: 1250
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4. Decrease in cellular nanovesicles concentration in blood of athletes more than 15 hours after marathonZala Jeras, Mitja Drab, Damjana Drobne, Apolonija Bedina Zavec, Mojca Benčina, Barbara Drašler, Matej Hočevar, Judita Lea Krek, Ljubiša Pađen, Manca Pajnič, Neža Repar, Boštjan Šimunič, Roman Štukelj, Veronika Kralj-Iglič, 2021, izvirni znanstveni članek Povzetek: Introduction: Cellular nanovesicles (CNVs), that are shed from cells, have been recognized as promising indicators of health status. We analyzed the effect of long-distance running on concentration of CNVs, along with some standard blood parameters, in 27 athletes two days before and > 15 hours after physical effort. Methods: CNVs were isolated by repetitive centrifugation and washing of samples, and assessed by flow cytometry. Cholinesterase (ChE) and glutathione S-transferase (GST) activity were measured spectrophotometrically. Interleukin 6 (IL-6) and tumor necrosis factor-% (TNF-%) concentrations were measured using enzyme-linked immunosorbent assay (ELISA). C-reactive protein (CRP) was measured with immunoturbidimetric determination and lipidogram parameters were measured by enzymatic colorimetric assay. Flow cytometry was used for blood cell count and mean platelet volume (MPV) measurement. Results: More than 15 hours after physical effort a decrease was found in CNVs% concentration in isolates from blood (46%; p< 0.05), in ChE activity in whole blood (47%; p< 0.001), in plasma (34%; p< 0.01), and in erythrocyte suspension (54%; p< 0.001), as well as in GST activity in erythrocyte suspension (16%; p< 0.01) and in IL-6 concentration in plasma (63%; p< 0.05). We found no change in GST activity in plasma and in TNF-% concentration in plasma. Correlations (> 0.8; p< 0.001) between CNVs% concentration and ChE activity, and GST activity, respectively, in erythrocyte suspension were found. Conclusion: We found that > 15 hours post-physical effort, CNVs% concentration was below the initial value, concomitant with other measured parameters: ChE and GST activity as well as IL-6 concentration, indicating a favorable effect of physical effort on health status. CNVs% concentration and ChE activity in isolates from peripheral blood proved to have potential as indicators of the response of the human body to inflammation after physical effort. Physical activity should be considered as an important factor in preparation of subjects for blood sampling in procedures focusing on CNV-containing diagnostic and therapeutic compounds.
Ključne besede: membrane vesiculation, physical effort, blood samples, inflammation process, cellular nanovesicles, marathon
Objavljeno v DiRROS: 25.01.2021; Ogledov: 2809; Prenosov: 6728
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