1. The effect of taVNS at 25 Hz and 100 Hz on Parkinson's disease gait : a randomized motion sensor studyVesna M. Van Midden, Urban Simončič, Zvezdan Pirtošek, Maja Kojović, 2024, izvirni znanstveni članek Povzetek: Background: Transcutaneous electrostimulation of the auricular branch of the vagal nerve (taVNS) has the propensity to reach diffuse neuromodulatory networks, which are dysfunctional in Parkinson's disease (PD). Previous studies support the use of taVNS as an add-on treatment for gait in PD. Objectives: We assessed the effect of taVNS at 25 Hz (taVNS25), taVNS at 100 Hz (taVNS100), and sham earlobe stimulation (sVNS) on levodopa responsive (arm swing velocity, arm range of motion, stride length, gait speed) and non-responsive gait characteristics (arm range of motion asymmetry, anticipatory postural adjustment [APA] duration, APA first step duration, APA first step range of motion), and turns (first turn duration, double 360° turn duration, steps per turn) in advanced PD. Methods: In our double blind sham controlled within-subject randomized trial, we included 30 PD patients (modified Hoehn and Yahr stage, 2.5–4) to assess the effect of taVNS25, taVNS100, and sVNS on gait characteristics measured with inertial motion sensors during the instrumented stand and walk test and a double 360° turn. Separate generalized mixed models were built for each gait characteristic. Results: During taVNS100 compared to sVNS arm swing velocity (P = 0.030) and stride length increased (P = 0.027), and APA duration decreased (P = 0.050). During taVNS25 compared to sVNS stride length (P = 0.024) and gait speed (P = 0.021) increased and double 360° turn duration decreased (P = 0.039). Conclusions: We have found that taVNS has a frequency specific propensity to improve stride length, arm swing velocity, and gait speed and double 360° turn duration in PD patients.
Ključne besede: Parkinsonova bolezen
Objavljeno v DiRROS: 12.06.2026; Ogledov: 249; Prenosov: 266
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2. Metabolic brain networks in dementia with Lewy bodies : from prodromal to manifest disease stagesMatej Perovnik, Urban Simončič, Jan Jamšek, Milica Gregorič Kramberger, Joachim Brumberg, Philipp Tobias Meyer, Daniela Perani, Maja Trošt, 2025, izvirni znanstveni članek Povzetek: Background: Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, yet it remains under-recognised and misdiagnosed, which delays treatment, causes inaccurate prognosis and limits research opportunities. Imaging with 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) is a supportive DLB biomarker. We evaluated a multivariate, quantifiable metabolic network biomarker, termed DLB-related pattern (DLBRP), for its further clinical translation across centres and disease stages. Methods: We analysed demographic, clinical and FDG PET imaging data of 1180 participants from 14 tertiary centres and two multicentre datasets. We included 379 DLB, 28 mild cognitive impairment-LB (MCI-LB), 195 dementia due to Alzheimer's disease (ADD), 172 MCI-AD without α-synuclein co-pathology (MCI-AD-S-), and 73 MCI-AD with α-synuclein co-pathology (S+) patients, along with a comparative group of 333 normal controls (NCs). From the scans, we calculated the expression of DLBRP, AD-related pattern (ADRP) and Parkinson's disease-related pattern (PDRP) and compared them across groups. DLBRP scores were correlated with clinical measurements. Results: Across independent cohorts, DLBRP robustly distinguished DLB from NCs (sensitivity >89%, specificity >90%), and scores correlated with Unified Parkinson's Disease Rating Scale Part III and independently predicted Mini-Mental State Examination. DLBRP was elevated already in MCI-LB. In a small longitudinal dataset, we observed steady increases in DLBRP expression with scores exceeding the diagnostic threshold prior to dementia onset. DLBRP and PDRP discriminated DLB from ADD (sensitivity, 74%-90%; specificity, 80%). In MCI-AD groups, ADRP was expressed, whereas DLBRP and PDRP were increased only in MCI-AD-S+, although comparatively less than in MCI-LB. Conclusions: This study demonstrates the value of DLBRP in diagnosing prodromal and manifest DLB and distinguishing them from their AD counterparts. While overlap between patterns may reflect actual co-pathology, this possibility cannot be accepted without thorough pathological confirmation. The current findings support the use of DLBRP in patient evaluation and in future trial design.
Ključne besede: Alzheimer's disease, Lewy body dementia, FDG PET, functional imaging, mild cognitive impairment
Objavljeno v DiRROS: 19.03.2026; Ogledov: 393; Prenosov: 271
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3. Multinomial logistic regression algorithm for the classification of patients with parkinsonismsEva Štokelj, Tomaž Rus, Jan Jamšek, Maja Trošt, Urban Simončič, 2025, izvirni znanstveni članek Ključne besede: neurology, parkinsonisms, brain, medical imaging
Objavljeno v DiRROS: 18.02.2026; Ogledov: 541; Prenosov: 263
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4. Imaging microvascular changes in nonocular oncological clinical applications by optical coherence tomography angiography : a literature reviewRok Hren, Gregor Serša, Urban Simončič, Matija Milanič, 2023, pregledni znanstveni članek Ključne besede: optical coherence tomography, angiography, endoscopy, oncology, skin carcinoma
Objavljeno v DiRROS: 26.07.2024; Ogledov: 1606; Prenosov: 830
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7. ▫$[^{18}\mathrm F]$▫FDG PET immunotherapy radiomics signature (iRADIOMICS) predicts response of non-small-cell lung cancer patients treated with pembrolizumabDamijan Valentinuzzi, Martina Vrankar, Nina Boc, Valentina Ahac, Žiga Zupančič, Mojca Unk, Katja Škalič, Ivana Žagar, Andrej Studen, Urban Simončič, Jens C. Eickhoff, Robert Jeraj, 2020, izvirni znanstveni članek Ključne besede: medical physics, medical imaging, oncology
Objavljeno v DiRROS: 15.07.2024; Ogledov: 1240; Prenosov: 491
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8. Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CTSebastijan Rep, Luka Ležaič, Tomaž Kocjan, Marija Pfeifer, Mojca Jensterle Sever, Urban Simončič, Petra Tomše, Marko Hočevar, 2015, izvirni znanstveni članek Ključne besede: lesions representing enlarged parathyroid tissue, triple-phase, standardized uptake value, retention index, lesion contrast, rak (medicina), obščitnični adenomi, diagnostika
Objavljeno v DiRROS: 22.04.2024; Ogledov: 1895; Prenosov: 1209
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