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1.
Long term results of follow-up after HPV self-sampling with devices Qvintip and HerSwab in women non-attending cervical screening programme
Teodora Bokan, Urška Ivanuš, Tine Jerman, Iztok Takač, Darja Arko, 2021, izvirni znanstveni članek

Povzetek: We are presenting the results of the Slovenian human papillomaviruses (HPV) self-sampling pilot study in colposcopy population of National Cervical Cancer Screening Programme ZORA for the first time. One-year and four-year follow-up results are presented for two different self-sampling devices. Participants and methods. A total of 209 women were enrolled in the study at colposcopy clinic. Prior to the gynaecological examination, all women performed self-collected vaginal swab at the clinic; 111 using Qvintip and 98 using HerSwab self-sampling device. After self-sampling, two cervical smears were taken by a clinician; first for conventional cytology and second for HPV test. After that, all women underwent colposcopy and a cervical biopsy if needed. We compared sensitivity, specificity, and predictive values of cytology (at the cut-off atypical squamous cells of undetermined significance or more [ASC-US+]) and HPV test (on self- and clinician-taken samples) for the detection of cervical intraepithelial neoplasia grade 2 or more (CIN2+) after one and four years of follow-up. Hybrid Capture 2 (HC2) assay was used for all HPV testing. Results. The mean age of 209 women was 37.6 years and HPV positivity rate 67.0% (140/209), 36.9 years and 70.3% (78/111) in the Qvintip group and 38.4 years and 63.3% (62/98) in the HerSwab group, respectively. Overall, percent agreement between self and clinician-taken samples was 81.8% (kappa 0.534) in the Qvintip and 77.1% (kappa 0.456) in the HerSwab group. In the Qvintip group, the longitudinal sensitivity, specificity, positive and negative predictive values were 71.8%, 75.0%, 83.6%, 60.0% for cytology; 83.1%, 51.3%, 75.6% and 62.5% for HPV test of self-taken samples and 94.4%, 57.5%, 79.8% and 85.2% for HPV test on clinician-taken samples. In the HerSwab group, the corresponding results were 71.7%, 46.7%, 61.3%, 58.3% for cytology; 75.0%, 47.7%, 62.9% and 61.8% for HPV test on self-taken samples and 94.3%, 44.4%, 66.7% and 87.0% for clinician-taken samples, respectively. Conclusions. The results confirm that HPV self-sampling is not as accurate as clinician sampling when HC2 is used. All HPV tests showed a higher sensitivity in detecting CIN2+ compared to cytology. Due to non-inferior longitudinal sensitivity of HPV self-sampling compared to cytology, HPV self-sampling might be an option for non-attenders to the National Cancer Screening Programme.
Ključne besede: HPV self-sampling, cytology, high-grade intraepithelial lesion, screening programmes
Objavljeno v DiRROS: 19.07.2024; Ogledov: 43; Prenosov: 11
.pdf Celotno besedilo (602,23 KB)

2.
Evaluation of the training program for p16/ Ki-67 dual immunocytochemical staining interpretation for laboratory staff without experience in cervical cytology and immunocytochemistry
Veronika Kloboves-Prevodnik, Živa Pohar-Marinšek, Janja Zalar, Hermina Rozina, Nika Kotnik, Tine Jerman, Jerneja Varl, Urška Ivanuš, 2020, izvirni znanstveni članek

Povzetek: ackground p16/Ki-67 dual immunocytochemical staining (DS) is considered easy to interpret if evaluators are properly trained, however, there is no consensus on what constitutes proper training. In the present study we evaluated a protocol for teaching DS evaluation on students inexperienced in cervical cytology. Methods Initial training on 40 DS conventional smears was provided by a senior cytotechnologist experienced in such evaluation. Afterwards, two students evaluated 118 cases. Additional training consisted mainly of discussing discrepant cases from the first evaluation and was followed by evaluation of new 383 cases. Agreement and accuracy of students' results were compared among the participants and to the results of the reference after both evaluations. We also noted time needed for evaluation of one slide as well as intra-observer variability of the teacher's results. Results At the end of the study, agreement between students and reference was higher compared to those after initial training (overall percent agreement [OPA] 81.4% for each student, kappa 0.512 and 0.527 vs. OPA 78.3% and 87.2%, kappa 0.556 and 0.713, respectively). However, accuracy results differed between the two students. After initial training sensitivity was 4.3% points and 2.9% points higher, respectively compared to the reference, while specificity was 30.6% points and 24.4% points lower, respectively, compared to the reference. At the end of the study, the sensitivity reached by one student was the same as that of the reference, while it was 2.6% points lower for the other student. There was a statistically significant difference in specificity between one student and the reference and also between students (16.7 and 15.1% points). Towards the end of the study, one student needed 5.2 min for evaluating one slide while the other needed 8.2 min. The intra-observer variability of the senior cytotechnologist was in the range of "very good" in both arms of the study. Conclusions In teaching DS evaluation, the students' progress has to be monitored using several criteria like agreement, accuracy and time needed for evaluating one slide. The monitoring process has to continue for a while after students reach satisfactory results in order to assure a continuous good performance. Monitoring of teacher's performance is also advisable.
Ključne besede: cervical cytology, cervical cancer, immunocytochemistry, accuracy
Objavljeno v DiRROS: 11.07.2024; Ogledov: 81; Prenosov: 50
.pdf Celotno besedilo (1,40 MB)
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Učinek cepljenja proti HPV v Sloveniji : analiza podatkov Registra ZORA
Kaja Batista, Tine Jerman, Urška Ivanuš, 2021, objavljeni znanstveni prispevek na konferenci

Ključne besede: epidemija, presejalni programi, rak materničnega vratu, javno zdravstvo
Objavljeno v DiRROS: 16.03.2022; Ogledov: 783; Prenosov: 383
.pdf Celotno besedilo (256,00 KB)
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7.
Poročilo o poteku študije za uvajanje tekočinske tehnologije v Sloveniji
Veronika Kloboves-Prevodnik, Mojca Florjančič, Tine Jerman, Jerneja Kos, Urška Ivanuš, 2021, objavljeni znanstveni prispevek na konferenci

Ključne besede: epidemija, presejalni programi, rak materničnega vratu, citopatologija
Objavljeno v DiRROS: 16.03.2022; Ogledov: 698; Prenosov: 382
.pdf Celotno besedilo (763,17 KB)
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8.
Značilnosti neodzivnic v programu ZORA
Mojca Florjančič, Tine Jerman, Urška Ivanuš, 2021, objavljeni znanstveni prispevek na konferenci

Ključne besede: epidemija, presejalni programi, rak materničnega vratu, javno zdravstvo
Objavljeno v DiRROS: 16.03.2022; Ogledov: 714; Prenosov: 378
.pdf Celotno besedilo (318,94 KB)
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9.
Opravljeno delo v letu 2020 in načrti programa ZORA za prihodnost
Urška Ivanuš, Mojca Florjančič, Tine Jerman, Blaž Podobnik, 2021, objavljeni znanstveni prispevek na konferenci

Ključne besede: epidemija, presejalni programi, rak materničnega vratu, javno zdravstvo
Objavljeno v DiRROS: 15.03.2022; Ogledov: 813; Prenosov: 396
.pdf Celotno besedilo (340,08 KB)
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10.
Poročilo o rezultatih programa ZORA v pandemskem letu 2020
Urška Ivanuš, Tine Jerman, Mojca Florjančič, 2021, objavljeni znanstveni prispevek na konferenci

Ključne besede: epidemija, presejalni programi, rak materničnega vratu, javno zdravstvo
Objavljeno v DiRROS: 15.03.2022; Ogledov: 748; Prenosov: 383
.pdf Celotno besedilo (1,74 MB)
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