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Hodgkinov limfom : vodnik za bolnike
Barbara Jezeršek Novaković, Samo Zver, Metka Zajc, Aleksandra Grbič, Andreja Cirila Škufca Smrdel, Eda Vrtačnik-Bokal, Vesna Šalamun, Vida Stržinar, Lorna Zadravec-Zaletel, Matej Pečovnik, 2016

Povzetek: Z vodnikom želimo tako bolnike kot svojce čim bolje seznaniti z najnovejšimi spoznanji o Hodgkinovem limfomu, njegovem odkrivanju, razjasniti osnove bolezni, predstaviti načine zdravljenja, ukrepe ob neželenih stranskih učinkih zdravljenja s kemoterapijo, poskrbeti za dobro osveščenost o možnostih ohranjanja plodnosti in možnih poznih posledicah zdravljenja, približati zavedanje o pomenu psihološke podpore bolniku in njegovim svojcem ter ponuditi pomoč Združenja L&L. Z ozaveščenostjo in pridobljenim znanjem lahko bolnik pri zdravljenju bolezni še bolj dejavno sodeluje s svojim zdravnikom in s tem pomembno prispeva k doseganju končnega cilja vsakega bolnika – k popolni ozdravitvi limfoma.
Ključne besede: rak (medicina), krvotvorne matične celice, transplantacija, psihološka pomoč, plodnost, hormonsko nadomestno zdravljenje
DiRROS - Objavljeno: 12.09.2016; Ogledov: 4759; Prenosov: 486
.pdf Celotno besedilo (836,58 KB)

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Akutna mieloična levkemija
Samo Zver, 2014

Ključne besede: levkemije, mieloična levkemija
DiRROS - Objavljeno: 02.04.2020; Ogledov: 678; Prenosov: 223
.pdf Celotno besedilo (137,37 KB)

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Routine KIT p.D816V screening identifies clonal mast cell disease in Hymenoptera allergic patients regularly missed using baseline tryptase levels alone
Peter Korošec, Jonathan J. Lyons, Mitja Košnik, Samo Zver, Vladka Čurin-Šerbec, Yihui Liu, Young Hwan Park, Ajda Demšar, Nisera Bajrović, Matevž Škerget, Peter Kopač, Mihaela Zidarn, Renato Eržen, Matija Rijavec, Julij Šelb, 2021

Povzetek: Background. Clonal mast cell disorders and elevated BST of unknown cause(s) are associated with severe Hymenoptera venom-triggered anaphylaxis (HVA). However, some individuals with clonal disease have normal BST (<11.4 ng/mL). Objective. To evaluate whether screening for KIT p.D816V in the blood is a useful clinical tool to risk-stratify patients with venom allergy. Methods. We prospectively recruited 374 patients with Hymenoptera allergy and no overt signs of mastocytosis referred to our center in the years 2018-19. KIT p.D816V was determined in the peripheral blood with qPCR and tryptase genotyping was performed by droplet-digital PCR. Results. 351 patients (93.9%) had normal levels of BST and KIT p.D816V was detected in 8% of patients (28/351), predominantly in patients with the most severe Mueller grade IV anaphylaxis (18.2%[24/132] vs 1.8%[4/88 in grade III; 0/131 in other grades] in lower grades; P<0.001). In grade IV patients with normal BST, KIT p.D816V was associated with more severe symptoms including a significantly higher frequency of loss of consciousness (58.3%[14/24] vs 34.3%[37/108]; P=0.03) and absence of skin symptoms (41.7%[10/24] vs 15.7%[17/108]; P=0.004). Among patients with normal BST, KIT p.D816V (OR [95%CI]: 10.25[3.75-36.14]; P<0.0001) was the major risk factor associated with severe HVA. Hereditary [alpha]-tryptasemia (H[alpha]T), due to increased germline copies of TPSAB1 encoding [alpha]-tryptase was the most common cause (65.2%; 15/23) of elevated BST in patients with HVA and together with KIT p.D816V accounted for 90% (20/23) of BST elevations in HVA patients. Conclusion. These results indicate that routine KIT p.D816V screening identifies clonal disease in high-risk HVA patients regularly missed using BST alone.
Ključne besede: anaphylaxis, venoms, hypersensitivity, hereditary alpha-tryptasemia
DiRROS - Objavljeno: 31.03.2021; Ogledov: 94; Prenosov: 41

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