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Povzetek: Introduction: The purpose of this study was to evaluate lipid profile and kidney function in children and adolescents with Type 1 Diabetes. Methods: This was a retrospective study including 324 children and adolescents with Type 1 Diabetes (48% females, mean age 13.1 ± 3.2 years). For all participants, demographic and clinical information were collected. The prevalence of dyslipidemia and kidney function markers were analyzed according to age. Multivariate linear regression analyses were performed to test the association of lipids or markers of renal function with demographic and clinical information (sex, age, disease duration, BMI SDS, HbA1c). Results: In our study the rate of dyslipidemia reached 32% in children <11 years and 18.5% in those ≥11 years. Children <11 years presented significantly higher triglyceride values. While the albumin-to-creatinine ratio was normal in all individuals, 17% had mildly reduced estimated glomerular filtration rate. Median of HbA1c was the most important determinant of lipids and kidney function, being associated with Total Cholesterol (p-value<0.001); LDL Cholesterol (pvalue= 0.009), HDL Cholesterol (p-value=0.045) and eGFR (p-value=0.001). Conclusion: Dyslipidemia could be present both in children and adolescents, suggesting that screening for markers of diabetic complications should be performed regardless of age, pubertal stage, or disease duration, to optimize glycemia and medical nutrition therapy and/or to start a specific medical treatment.
Ključne besede: type 1 diabetes, diabetes care, lipids profile, kidney function, age, guidelines
Objavljeno v DiRROS: 01.09.2026; Ogledov: 76; Prenosov: 41
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Povzetek: Artificial gravity (AG) combined with resistive vibration exercise has been proposed as a multi-system countermeasure for long-duration spaceflight; however, its operational feasibility during prolonged unloading remains insufficiently characterised. This study primarily evaluated the feasibility, tolerability, and adherence to a structured resistive vibration exercise protocol delivered either under artificial gravity (AGRVE) or in horizontal loading (HRVE) during 60 days of hypoxic (F[sub](IO2) = 0.14) 6° head-down tilt bed rest. Secondary observations included delayed-onset muscle soreness (DOMS) and changes in eight-repetition maximum strength (8RM) to inform load progression. Sixteen healthy male participants were allocated to HRVE (n = 9) or AGRVE (n = 8) and completed near-daily 30-min training sessions at light (30% 1RM) and moderate (50% 1RM) intensities. Adherence was high in both groups (HRVE: 98.5%; AGRVE: 96.3%). In AGRVE, early-session interruptions were primarily due to motion sickness or presyncopal symptoms; motion sickness severity declined significantly across repeated centrifugation exposures (P < 0.001), consistent with vestibular habituation. HRVE interruptions were predominantly fatigue-related. DOMS remained low throughout the intervention (typically 0–3/10). 8RM increased over time in both groups (P < 0.001). Progressive resistive vibration exercise can be implemented with high adherence during prolonged hypoxic bed rest, including when combined with AG. Motion sickness represents the principal early operational constraint specific to squat-based AG exposure but diminishes with repeated sessions.
Ključne besede: artificial gravity, resistive vibration exercise, exercise physiology
Objavljeno v DiRROS: 17.06.2026; Ogledov: 224; Prenosov: 237
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Ključne besede: tree-rings, climate, competition
Objavljeno v DiRROS: 12.05.2026; Ogledov: 349; Prenosov: 302
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Povzetek: Introduction: Resistive exercise combined with whole-body vibration (WBV) and short-arm human centrifugation is being considered as a countermeasure to mitigate muscle and bone loss in astronauts during prolonged space missions. WBV may provide exercise benefits or adverse effects on organs and the lower back. These effects may result from vibration transmitted throughout the body. The objective of this study was to compare vibration transmission (VT) from the ground to the body during resistance vibration exercise (RVE) comprising squat and calf raise performed on a rotational vibration plate. Specifically, we compared VT during RVE in the upright position (URVE) and on a short-arm human centrifuge (artificial gravity, AG) establishing a similar ground reaction force. The latter (AGRVE) is considered a potential countermeasure for microgravity-induced musculoskeletal deconditioning. Methods: Fifteen healthy males participated. They were assigned to two groups: one (n = 8) performed URVE at 20% of 1 repetition maximum (RM) squat; the other (n = 7) performed horizontal RVE during AG exposure (AGRVE), with a matching ground reaction force. Both groups were exposed to vibration at 20 Hz and 3–4 mm displacement (RMS value: 4 ± 0.14 g). VT was recorded during two sets of squats and calf raises. Three accelerometers recorded VT at: (i) the platform surface at the feet, (ii) lower back (L5), and (iii) forehead. Results: In both conditions, the lower limbs attenuated vibration transmission to the lower back (p < 0.0001). During AGRVE, both VT and pelvis octave-band RMS values were lower compared to URVE in both squat (p = 0.008 and p = 0.01) and calf raise (p = 0.007 and p = 0.01), suggesting potentially greater safety for the lower back. Conclusion: During RVE, whether in URVE or AGRVE, lower limbs effectively attenuated vibrations, resulting in negligible pelvic exposure. AGRVE may represent a safer alternative to URVE due to reduced transmission to the lower back and adjacent sensitive regions.
Ključne besede: simulator, vibration, vibration transmission, vibration exercise, resistance exercise, exercise, artificial gravity
Objavljeno v DiRROS: 28.01.2026; Ogledov: 683; Prenosov: 432
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Ključne besede: pigs breeds, swine, authentication, near-infrared spectroscopy, discriminant analysis of principal components (DAPC), local breeds, near infrared spectroscopy, identification, vlassification
Objavljeno v DiRROS: 23.12.2025; Ogledov: 622; Prenosov: 474
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