1. A multidisciplinary skull base board for tumour and non-tumour diseases : initial experiencesJure Urbančič, Saba Battelino, Roman Bošnjak, Tomislav Felbabić, Nejc Steiner, Matej Vouk, Matej Vrabec, Domen Vozel, 2024, izvirni znanstveni članek Povzetek: The skull base is the area where various cancerous and non-cancerous diseases occur and represents the intersection of several medical fields. The key is an integrated treatment by specialists of multiple disciplines. We prospectively analysed patients with a skull base disease between August 2022 and 2023 and presented to the Multidisciplinary Skull Base Board (MDT-SB), which takes place once a month hybridly (in-person and remotely). Thirty-nine patients (median age of 58.2 years) were included, of which twelve (30.8%) had a benign tumour, twelve (30.8%) had a malignant tumour, five had an infection (12.8%), and ten (25.6%) had other diseases. For each patient, at least two otorhinolaryngologists, a neurosurgeon, and a neuroradiologist, as well as an infectious disease specialist, a paediatrician, an oculoplastic surgeon, a maxillofacial surgeon, and a pathologist were involved in 10%, 8%, 8%, 3%, and 3% of cases, respectively. In fifteen patients (38%), the MDT-SB suggested surgical treatment; in fourteen (36%), radiological follow-ups; in five (13%), non-surgical treatments; in two, conservative treatments (5%); in two (5%), surgical and conservative treatments; and in one (3%), a biopsy. Non-cancerous and cancerous diseases of the skull base in adults and children should be presented to the MDT-SB, which consists of at least an otolaryngologist, a neurosurgeon, and a neuroradiologist.
Ključne besede: skull base neoplasms, carcinoma, remote consultation, paranasal sinuses, ear neoplasms, invasive fungal infections, central nervous system neoplasms, cranial nerve disorders, neuroendoscopy
Objavljeno v DiRROS: 12.06.2026; Ogledov: 257; Prenosov: 190
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2. Quality of life in Slovenian patients with skull base tumours : cross-cultural adaptation and validation of a Slovenian skull base inventoryDomen Vozel, Jure Urbančič, Saba Battelino, Nina Božanić Urbančič, Nejc Steiner, Tomislav Felbabić, Roman Bošnjak, 2026, izvirni znanstveni članek Povzetek: Background: Skull base tumours frequently manifest as severe physical morbidity and quality of life (QoL) impairment. The disease-related QoL measurement can be performed with disease specific questionnaires, e.g. Skull base inventory (SBI). Patients and methods: The study consisted of two parts: (1) cross-cultural adaptation and psychometric testing of the Slovenian SBI (SBI-SLO) and (2) QoL assessment in skull base tumours. Two groups completed the SBI-SLO: 1.) adult patients without prior treatment of anterior, anterolateral and/or central skull base and 2.) healthy controls. Patients with skull-base tumours were further analysed for difference in SBI-SLO total score and domain scores between 1.) benign and malignant tumours and 2.) pituitary macroadenomas and other benign tumours. Results: 59 patients (46% male, 54% female, median age 57.7 years) and 47 subjects from control group (49% male, 51% female, median age 42,2 years) completed SBI-SLO, which demonstrated an excellent level of internal consistency (Cronbach's alpha = 0.924) and excellent test-retest reliability (intraclass correlation coefficient [ICCA] = 0.952). The discriminant validity was confirmed (p = 0.000). SBI-SLO total score, emotional, other and family domain scores were lower in malignant than in benign tumours (p = 0.031, p = 0.038, p = 0.008, and p = 0.046, respectively). Macroadenoma and other benign tumours differed only in neurological domain score (p < 0.05). Conclusions: A skull base tumour, especially malignant, can exert a substantial detrimental effect on a patient's quality of life. The SBI is a key tool for assessing QoL, also available in Slovenian.
Ključne besede: quality of life, skull base, neoplasms, meningioma, carcinoma
Objavljeno v DiRROS: 24.04.2026; Ogledov: 390; Prenosov: 353
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3. Enhancing the outcomes of temporalis fascia tympanoplasty using autologous platelet-rich plasma and gel : a randomized controlled trialNejc Steiner, Domen Vozel, Nina Božanić Urbančič, Kaja Troha, Andraž Lazar, Veronika Kralj-Iglič, Saba Battelino, 2025, izvirni znanstveni članek Ključne besede: tympanoplasty, platelet-rich plasma (PRP), platelet-rich gel (PRG), extracellular vesicles, tympanic membrane perforation, cartilage graft, hearing improvement, quality of life, randomized controlled trial, otologic surgery
Objavljeno v DiRROS: 19.02.2026; Ogledov: 584; Prenosov: 314
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4. Autologous platelet and extracellular vesicle-rich plasma as therapeutic fluid : a reviewKaja Troha, Domen Vozel, Matevž Arko, Apolonija Bedina Zavec, Drago Dolinar, Matej Hočevar, Zala Jeras, Matic Kisovec, Boštjan Kocjančič, Ljubiša Pađen, Manca Pajnič, Samo Penič, Anna Romolo, Neža Repar, Vesna Spasovski, Nejc Steiner, Vid Šuštar, Aleš Iglič, Damjana Drobne, Ksenija Kogej, Saba Battelino, Veronika Kralj-Iglič, 2023, pregledni znanstveni članek Ključne besede: platelet-rich plasma, platelets, centrifugation, extracellular vesicles, small cellular particles, wound healing, regeneration, fresh-frozen plasma, intercellular signaling peptides and proteins
Objavljeno v DiRROS: 26.01.2024; Ogledov: 1976; Prenosov: 1275
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