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Iskalni niz: "avtor" (Nežka Hribernik) .

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Imunoterapevtski pristopi pri zdravljenju limfoproliferativnih bolezni
Marko Boc, 2022, druge monografije in druga zaključena dela

Ključne besede: limfomi, imunoterapija, limfoproliferativne bolezni
Objavljeno v DiRROS: 17.11.2022; Ogledov: 61; Prenosov: 18
.pdf Celotno besedilo (15,82 MB)
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Quantitative imaging biomarkers of immune-related adverse events in immune-checkpoint blockade-treated metastatic melanoma patients : a pilot study
Nežka Hribernik, Daniel T. Huff, Andrej Studen, Katarina Zevnik, Žan Klaneček, Hamid Emamekhoo, Katja Škalič, Robert Jeraj, Martina Reberšek, 2022, izvirni znanstveni članek

Povzetek: Purpose: To develop quantitative molecular imaging biomarkers of immune-related adverse event (irAE) development in malignant melanoma (MM) patients receiving immune-checkpoint inhibitors (ICI) imaged with 18F-FDG PET/CT. Methods: 18F-FDG PET/CT images of 58 MM patients treated with anti-PD-1 or anti-CTLA-4 ICI were retrospectively analyzed for indication of irAE. Three target organs, most commonly affected by irAE, were considered: bowel, lung, and thyroid. Patient charts were reviewed to identify which patients experienced irAE, irAE grade, and time to irAE diagnosis. Target organs were segmented using a convolutional neural network (CNN), and novel quantitative imaging biomarkers - SUV percentiles (SUVX%) of 18F-FDG uptake within the target organs - were correlated with the clinical irAE status. Area under the receiver-operating characteristic curve (AUROC) was used to quantify irAE detection performance. Patients who did not experience irAE were used to establish normal ranges for target organ 18F-FDG uptake. Results: A total of 31% (18/58) patients experienced irAE in the three target organs: bowel (n=6), lung (n=5), and thyroid (n=9). Optimal percentiles for identifying irAE were bowel (SUV95%, AUROC=0.79), lung (SUV95%, AUROC=0.98), and thyroid (SUV75%, AUROC=0.88). Optimal cut-offs for irAE detection were bowel (SUV95%>2.7 g/mL), lung (SUV95%>1.7 g/mL), and thyroid (SUV75%>2.1 g/mL). Normal ranges (95% confidence interval) for the SUV percentiles in patients without irAE were bowel [1.74, 2.86 g/mL], lung [0.73, 1.46 g/mL], and thyroid [0.86, 1.99 g/mL]. Conclusions: Increased 18F-FDG uptake within irAE-affected organs provides predictive information about the development of irAE in MM patients receiving ICI and represents a potential quantitative imaging biomarker for irAE. Some irAE can be detected on 18F-FDG PET/CT well before clinical symptoms appear.
Ključne besede: melanoma, malignant melanoma, immune-checkpoint inhibitors, molecular imaging biomarkers
Objavljeno v DiRROS: 07.09.2022; Ogledov: 108; Prenosov: 42
.pdf Celotno besedilo (9,65 MB)

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Zaviralci imunskih kontrolnih točk in imunsko pogojeni neželeni učinki
Nežka Hribernik, 2022, objavljeni znanstveni prispevek na konferenci

Ključne besede: imunoterapija, zaviralci imunskih nadzornih točk, neželeni učinki, multidisciplinarna obravnava
Objavljeno v DiRROS: 02.09.2022; Ogledov: 127; Prenosov: 58
.pdf Celotno besedilo (226,36 KB)
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Dnevnik zdravljenja z zdravilom regorafenib
Janja Ocvirk, Martina Reberšek, Neva Volk, Tanja Mesti, Marko Boc, Marija Ignjatović, Nežka Hribernik, 2022, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid

Ključne besede: kemoterapija, rak debelega črevesa in danke, gastrointestinalni tumorji
Objavljeno v DiRROS: 14.07.2022; Ogledov: 329; Prenosov: 68
.pdf Celotno besedilo (2,48 MB)

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Klinični primer bolnika z BRAF V600 mutiranim, mejno resektabilnim kožnim melanomom in KLL : Elektronski vir
Karla Berlec, Nežka Hribernik, 2022, objavljeni znanstveni prispevek na konferenci

Ključne besede: melanom, rak kože, kemoterapija
Objavljeno v DiRROS: 11.04.2022; Ogledov: 181; Prenosov: 88
.pdf Celotno besedilo (296,70 KB)

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Sistemsko zdravljenje melanomskih bolnikov z metastazami v centralnem živčnem sistemu : Elektronski vir
Nežka Hribernik, 2022, objavljeni znanstveni prispevek na konferenci

Ključne besede: melanom, rak kože, sistemsko zdravljenje
Objavljeno v DiRROS: 11.04.2022; Ogledov: 214; Prenosov: 77
.pdf Celotno besedilo (429,44 KB)

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Priporočila za obravnavo bolnikov z rakom debelega črevesa in danke
2020, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid

Ključne besede: rak debelega črevesa, rak danke, bolniki, zdravljenje
Objavljeno v DiRROS: 18.03.2022; Ogledov: 343; Prenosov: 159
.pdf Celotno besedilo (1,30 MB)
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