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Microsatellite instability in colorectal cancer
Matej Horvat, Borut Štabuc, 2011, pregledni znanstveni članek

Povzetek: Background. Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequenceof inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis colorectal cancer (HNPCC) represents 10-20%. Microsatellite sequences (MS) arerepeated sequences of short stretches of DNA all over the genome. Microsatellite stability (MSS) means MS are the same in each cell of an individual, whereas microsatellite instability (MSI-H) means MS differ in normal and cancer cells of an individual. The cause of MSI-H is a damaged mismatch repair mechanism (MMR), with the most important MMR proteins being MSH2, MLH1 and MSH6. Conclusions. MSI-H seems to be an important prognostic factor in CRC and an important predictive factor of CRC chemotherapeutic treatment efficacy. Clinical trials conducted until now have shown contradictory findings in different chemotherapeutic settings, adjuvant and palliative; therefore MSI-H is going to be the object of the future research. The future of cancer treatment is in the individualized therapy based on molecular characteristics of the tumour, such as MSI-H in CRC.
Objavljeno v DiRROS: 19.03.2024; Ogledov: 70; Prenosov: 41
.pdf Celotno besedilo (489,56 KB)
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Titanium dioxide in our everyday life : is it safe?
Matej Skočaj, Metka Filipič, Jana Nunić, Saša Novak, 2011, pregledni znanstveni članek

Objavljeno v DiRROS: 19.03.2024; Ogledov: 52; Prenosov: 19
.pdf Celotno besedilo (794,00 KB)

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Qualitative analysis of the minimal Higgins model of glycolysis
Brigita Ferčec, Matej Mencinger, Tatjana Petek, Orhan Ozgur Aybar, Ilknur Kusbeyzi Aybar, 2023, izvirni znanstveni članek

Povzetek: Glycolysis, one of the leading metabolic pathways, involves many different periodic oscillations emerging at positive steady states of the biochemical models describing this essential process. One of the models employing the molecular diffusion of intermediates is the Higgins biochemical model to explain sustained oscillations. In this paper, we investigate the center-focus problem for the minimal Higgins model for general values of the model parameters with the help of computational algebra. We demonstrate that the model always has a stable focus point by finding a general form of the first Lyapunov number. Then, varying two of the model parameters, we obtain the first three coefficients of the period function for the stable focus point of the model and prove that the singular point is actually a bi-weak monodromic equilibrium point of type $[1, 2]$. Additionally, we prove that there are two (small) intervals for a chosen parameter $a > 0$ for which one critical period bifurcates from this singular point after small perturbations.
Ključne besede: biological processes, biochemical models, glycolysis
Objavljeno v DiRROS: 18.03.2024; Ogledov: 55; Prenosov: 30
.pdf Celotno besedilo (837,28 KB)
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Cryogenic transmission electron images of Phaeodactylum tricornutum isolates of small cellular particles
Apolonija Bedina Zavec, Darja Božič, Matej Hočevar, Aleš Iglič, Marko Jeran, Veronika Kralj-Iglič, Anna Romolo, 2024, objavljeni znanstveni prispevek na konferenci

Objavljeno v DiRROS: 08.03.2024; Ogledov: 57; Prenosov: 43
.pdf Celotno besedilo (24,27 MB)
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Scanning electron microscope images of Phaeodactylum tricornutum culture
Apolonija Bedina Zavec, Darja Božič, Matej Hočevar, Aleš Iglič, Marko Jeran, Veronika Kralj-Iglič, Anna Romolo, 2024, objavljeni znanstveni prispevek na konferenci

Objavljeno v DiRROS: 08.03.2024; Ogledov: 62; Prenosov: 46
.pdf Celotno besedilo (56,37 MB)
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